The Rejuvenation of Aged Stem Cells for Cardiac Repair

Canadian Journal of Cardiology

Volumn 30, Issue 11, 2014, Pages 1299-1306

  Ludke, Ana ^a,b   Li, Ren Ke ^a,b   Weisel, Richard D ^a,b  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT STEM CELL; AGING; CARDIOVASCULAR DISEASE; CELL AGING; CELL REGENERATION; DONOR; HEART SURGERY; REGENERATIVE MEDICINE; REJUVENATION; REVIEW; STEM CELL TRANSPLANTATION; TARGET ORGAN; ANIMAL; HEART DISEASES; HUMAN; ORGANIZATION AND MANAGEMENT; PATHOLOGY; PHYSIOLOGY; PROCEDURES; STEM CELL;

AGING; ANIMALS; HEART DISEASES; HUMANS; REGENERATIVE MEDICINE; REJUVENATION; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 84908501619     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2014.03.021     Document Type: Review

References (77)

1. Population by sex and age group, by province and territory. Statistics Canada. Available at: . Updated November 25, 2013. Accessed February 10, 2014. http://www.statcan.gc.ca/tables-tableaux/sum-som/l01/cst01/demo31a-eng.htm.
2. Greenberger R. Juan Ponce de Leon: The Exploration of Florida and the Search for the Fountain of Youth (Library of Explorers and Exploration). New York: Rosen Publishing Group,2003.
3. Golden T.R., Hinerfeld D.A., Melov S. Oxidative stress and aging: beyond correlation. Aging Cell 2002, 1:117-123.
4. Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
5. Tatar M., Bartke A., Antebi A. The endocrine regulation of aging by insulin-like signals. Science 2003, 299:1346-1351.
6. Hekimi S., Guarente L. Genetics and the specificity of the aging process. Science 2003, 299:1351-1354.
7. Jaskelioff M., Muller F.L., Paik J.H., et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011, 469:102-106.
8. Zhang G., Li J., Purkayastha S., et al. Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature 2013, 497:211-216.
9. Hayflick L. The limited invitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37:614-636.
10. Chimenti C., Kajstura J., Torella D., et al. Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ Res 2003, 93:604-613.
11. Sharpless N.E., DePinho R.A. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007, 8:703-713.
12. Conboy I.M., Conboy M.J., Wagers A.J., et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005, 433:760-764.
13. Sudo K., Ema H., Morita Y., Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. JExp Med 2000, 192:1273-1280.
14. Xing Z., Ryan M.A., Daria D., et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 2006, 108:2190-2197.
15. Wong K.K., Maser R.S., Bachoo R.M., et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 2003, 421:643-648.
16. Kuhn H.G., Dickinson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. JNeurosci 1996, 16:2027-2033.
17. Fazel S., Cimini M., Chen L., et al. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. JClin Invest 2006, 116:1865-1877.
18. Li S.H., Sun Z., Brunt K.R., et al. Reconstitution of aged bone marrow with young cells repopulates cardiac-resident bone marrow-derived progenitor cells and prevents cardiac dysfunction after a myocardial infarction. Eur Heart J 2013, 34:1157-1167.
19. Capogrossi M.C. Cardiac stem cells fail with aging: a new mechanism for the age-dependent decline in cardiac function. Circ Res 2004, 94:411-413.
20. Cesselli D., Beltrami A.P., D'Aurizio F., et al. Effects of age and heart failure on human cardiac stem cell function. Am J Pathol 2011, 179:349-366.
21. Bearzi C., Rota M., Hosoda T., et al. Human cardiac stem cells. Proc Natl Acad Sci U S A 2007, 104:14068-14073.
22. Lakatta E.G., Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease. Circulation 2003, 107:346-354.
23. Olivetti G., Giordano G., Corradi D., et al. Gender differences and aging: effects on the human heart. JAm Coll Cardiol 1995, 26:1068-1079.
24. Bergmann O., Bhardwaj R.D., Bernard S., et al. Evidence for cardiomyocyte renewal in humans. Science 2009, 324:98-102.
25. Lawton K.A., Berger A., Mitchell M., et al. Analysis of the adult human plasma metabolome. Pharmacogenomics 2008, 9:383-397.
26. Edwards M.G., Anderson R.M., Yuan M., et al. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics 2007, 8:80.
27. Chakkalakal J.V., Jones K.M., Basson M.A., Brack A.S. The aged niche disrupts muscle stem cell quiescence. Nature 2012, 490:355-360.
28. Sanada F., Kim J., Czarna A., et al. c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy. Circ Res 2014, 114:41-55.
29. Mohyeldin A., Garzón-Muvdi T., Quiñones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 2010, 7:150-161.
30. Dimmeler S., Leri A. Aging and disease as modifiers of efficacy of cell therapy. Circ Res 2008, 102:1319-1330.
31. Edelberg J.M., Tang L., Hattori K., Lyden D., Rafii S. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res 2002, 90:E89-E93.
32. Zhuo Y., Li S.H., Chen M.S., et al. Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: combined consequences for cell therapy in older recipients. JThorac Cardiovasc Surg 2010, 139:1286-1294. 1294.e1-2.
33. Segers V.F., Lee R.T. Stem-cell therapy for cardiac disease. Nature 2008, 451:937-942.
34. Zhang H., Fazel S., Tian H., et al. Increasing donor age adversely impacts beneficial effects of bone marrow but not smooth muscle myocardial cell therapy. Am J Physiol Circ Physiol 2005, 289:H2089-H2096.
35. Shih H., Lee B., Lee R.J., Boyle A.J. The aging heart and post-infarction left ventricular remodeling. JAm Coll Cardiol 2011, 57:9-17.
36. Heeschen C., Lehmann R., Honold J., et al. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation 2004, 109:1615-1622.
37. Kissel C.K., Lehmann R., Assmus B., et al. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. JAm Coll Cardiol 2007, 49:2341-2349.
38. Kan C.D., Li S.H., Weisel R.D., Zhang S., Li R.K. Recipient age determines the cardiac functional improvement achieved by skeletal myoblast transplantation. JAm Coll Cardiol 2007, 50:1086-1092.
39. Fan M., Chen W., Liu W., et al. The effect of age on the efficacy of human mesenchymal stem cell transplantation after a myocardial infarction. Rejuvenation Res 2010, 13:429-438.
40. Chidgey A., Dudakov J., Seach N., Boyd R. Impact of niche aging on thymic regeneration and immune reconstitution. Semin Immunol 2007, 19:331-340.
41. Kajstura J., Gurusamy N., Ogorek B., et al. Myocyte turnover in the aging human heart. Circ Res 2010, 107:1374-1386.
42. Beltrami A.P., Cesselli D., Beltrami C.A. Stem cell senescence and regenerative paradigms. Clin Pharmacol Ther 2012, 91:21-29.
43. Knoblich J.A. Mechanisms of asymmetric stem cell division. Cell 2008, 132:583-597.
44. Liu L., Rando T.A. Manifestations and mechanisms of stem cell aging. JCell Biol 2011, 193:257-266.
45. Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007, 8:729-740.
46. Ayach B.B., Yoshimitsu M., Dawood F., et al. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 2006, 103:2304-2309.
47. Smith M.A., Pallister C.J., Smith J.G. Stem cell factor: biology and relevance to clinical practice. Acta Haematol 2001, 105:143-150.
48. Hsieh P.C., Segers V.F., Davis M.E., et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med 2007, 13:970-974.
49. Oh H., Bradfute S.B., Gallardo T.D., et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 2003, 100:12313-12318.
50. Beltrami A.P., Barlucchi L., Torella D., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003, 114:763-776.
51. Urbanek K., Rota M., Cascapera S., et al. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res 2005, 97:663-673.
52. Linke A., Müller P., Nurzynska D., et al. Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A 2005, 102:8966-8971.
53. Sturzu A.C., Wu S.M. Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res 2011, 108:353-364.
54. Mohsin S., Khan M., Toko H., et al. Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. JAm Coll Cardiol 2012, 60:1278-1287.
55. Scheubel R.J., Zorn H., Silber R.E., et al. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. JAm Coll Cardiol 2003, 42:2073-2080.
56. Gennaro G., Menard C., Michaud S.E., Rivard A. Age-dependent impairment of reendothelialization after arterial injury: role of vascular endothelial growth factor. Circulation 2003, 107:230-233.
57. Pouzet B., Vilquin J.T., Hagege A.A., et al. Factors affecting functional outcome after autologous skeletal myoblast transplantation. Ann Thorac Surg 2001, 71:844-850. [discussion: 850-1].
58. Mohsin S., Khan M., Nguyen J., et al. Rejuvenation of human cardiac progenitor cells with Pim-1 kinase. Circ Res 2013, 113:1169-1179.
59. Nakamura Y., Yasuda T., Weisel R.D., Li R.K. Enhanced cell transplantation: preventing apoptosis increases cell survival and ventricular function. Am J Physiol Heart Circ Physiol 2006, 291:H939-H947.
60. Brunt K.R., Zhang Y., Mihic A., et al. Role of WNT/beta-catenin signaling in rejuvenating myogenic differentiation of aged mesenchymal stem cells from cardiac patients. Am J Pathol 2012, 181:2067-2078.
61. Hare J.M., Fishman J.E., Gerstenblith G., et al. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA 2012, 308:2369-2379.
62. Dhingra S., Li P., Huang X.P., et al. Preserving prostaglandin E2 level prevents rejection of implanted allogeneic mesenchymal stem cells and restores postinfarction ventricular function. Circulation 2013, 128(11 suppl 1):S69-S78.
63. Loffredo F.S., Steinhauser M.L., Jay S.M., et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 2013, 153:828-839.
64. Kang K., Sun L., Xiao Y., et al. Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration. JAm Coll Cardiol 2012, 60:2237-2249.
65. Mangi A.A., Noiseux N., Kong D., et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003, 9:1195-1201.
66. Noiseux N., Gnecchi M., Lopez-Ilasaca M., et al. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther J Am Soc Gene Ther 2006, 14:840-850.
67. Bachmann M., Möröy T. The serine/threonine kinase Pim-1. Int J Biochem Cell Biol 2005, 37:726-730.
68. Muraski J.A., Rota M., Misao Y., et al. Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med 2007, 13:1467-1475.
69. Shirogane T., Fukada T., Muller J.M., et al. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 1999, 11:709-719.
70. Borillo G.A., Mason M., Quijada P., et al. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res 2010, 106:1265-1274.
71. Sussman M.A. Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte. Expert Rev Cardiovasc Ther 2009, 7:929-938.
72. Cohen E.D., Tian Y., Morrisey E.E. Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development 2008, 135:789-798.
73. Paige S.L., Osugi T., Afanasiev O.K., et al. Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PloS One 2010, 5:e11134.
74. Hare J.M., Traverse J.H., Henry T.D., et al. Arandomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. JAm Coll Cardiol 2009, 54:2277-2286.
75. Penn M.S., Ellis S., Gandhi S., et al. Adventitial delivery of an allogeneic bone marrow-derived adherent stem cell in acute myocardial infarction: phase I clinical study. Circ Res 2012, 110:304-311.
76. Spaggiari G.M., Capobianco A., Abdelrazik H., et al. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood 2008, 111:1327-1333.
77. Huang X.P., Sun Z., Miyagi Y., et al. Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation 2010, 122:2419-2429.