Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair

Circulation

Volumn 122, Issue 23, 2010, Pages 2419-2429

  Huang, Xi Ping ^a   Sun, Zhuo ^a   Miyagi, Yasuo ^a   Kinkaid, Heather McDonald ^a   Zhang, Li ^b   Weisel, Richard D ^a   Li, Ren Ke ^a  

^a Division of Cardiovascular Surgery   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

immune system; myocardial infarction; stem cells; transplantation

Indexed keywords

AZACITIDINE; CD86 ANTIGEN; CYTOKINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYOD PROTEIN; TRANSCRIPTION FACTOR NKX2.5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; ECHOCARDIOGRAPHY; ENDOTHELIUM; FEMALE; HEART CATHETER; HEART FUNCTION; HEART INFARCTION; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; IN VITRO SELECTION; IN VIVO STUDY; LEUKOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE;

ANIMALS; CELL DIFFERENTIATION; FEMALE; ISOANTIGENS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MYOCARDIAL INFARCTION; RATS; RATS, INBRED LEW; RATS, WISTAR; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 78650686250     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.955971     Document Type: Article

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