-
1
-
-
34848902937
-
2+- And mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure
-
2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J. Clin. Invest. 117, 2431-2444 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2431-2444
-
-
Nakayama, H.1
Chen, X.2
Baines, C.P.3
-
2
-
-
34250729007
-
Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection
-
DOI 10.1159/000103747
-
Javadov S, Karmazyn M. Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol. Biochem. 20, 1-22 (2007). (Pubitemid 46956808)
-
(2007)
Cellular Physiology and Biochemistry
, vol.20
, Issue.1-4
, pp. 1-22
-
-
Javadov, S.1
Karmazyn, M.2
-
3
-
-
34247200969
-
RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis
-
DOI 10.1074/jbc.M604298200
-
Del Re DP, Miyamoto S, Brown JH. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J. Biol. Chem. 282, 8069-8078 (2007). (Pubitemid 47093605)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.11
, pp. 8069-8078
-
-
Del Re, D.P.1
Miyamoto, S.2
Brown, J.H.3
-
4
-
-
33947373973
-
Preconditioning: The mitochondrial connection
-
Murphy E, Steenbergen C. Preconditioning: the mitochondrial connection. Annu. Rev. Physiol. 69, 51-67 (2007).
-
(2007)
Annu. Rev. Physiol.
, vol.69
, pp. 51-67
-
-
Murphy, E.1
Steenbergen, C.2
-
5
-
-
14144250314
-
Mitochondrial function in cardiomyocytes: Target for cardioprotection
-
Das DK, Maulik N. Mitochondrial function in cardiomyocytes: target for cardioprotection. Curr. Opin. Anaesthesiol. 18, 77-82 (2005). (Pubitemid 40283852)
-
(2005)
Current Opinion in Anaesthesiology
, vol.18
, Issue.1
, pp. 77-82
-
-
Das, D.K.1
Maulik, N.2
-
6
-
-
18044379574
-
Mitochondrial DNA mutations activate programmed cell survival in the mouse heart
-
DOI 10.1152/ajpheart.00670.2004
-
Zhang D, Mott JL, Chang SW, Stevens M, Mikolajczak P, Zassenhaus HP. Mitochondrial DNA mutations activate programmed cell survival in the mouse heart. Am. J. Physiol. Heart Circ. Physiol. 288, H2476-H2483 (2005). (Pubitemid 40604137)
-
(2005)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.288
, Issue.5
-
-
Zhang, D.1
Mott, J.L.2
Chang, S.-W.3
Stevens, M.4
Mikolajczak, P.5
Zassenhaus, H.P.6
-
7
-
-
4944265466
-
Transgenic expression of Bcl-2 modulates energy metabolism, prevents cytosolic acidification during ischemia, and reduces ischemia/reperfusion injury
-
DOI 10.1161/01.RES.0000143898.67182.4c
-
Imahashi K, Schneider MD, Steenbergen C, Murphy E. Transgenic expression of Bcl-2 modulates energy metabolism, prevents cytosolic acidification during ischemia, and reduces ischemia/reperfusion injury. Circ. Res. 95, 734-741 (2004). (Pubitemid 39331934)
-
(2004)
Circulation Research
, vol.95
, Issue.7
, pp. 734-741
-
-
Imahashi, K.1
Schneider, M.D.2
Steenbergen, C.3
Murphy, E.4
-
8
-
-
1142309743
-
New directions for protecting the heart against ischaemia - Reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK)-pathway
-
Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia - reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc. Res. 61, 448-460 (2004).
-
(2004)
Cardiovasc. Res.
, vol.61
, pp. 448-460
-
-
Hausenloy, D.J.1
Yellon, D.M.2
-
9
-
-
0141956252
-
Mitochondrial function: The heart of myocardial preservation
-
DOI 10.1016/S0022-2143(03)00109-4
-
McFalls EO, Liem D, Schoonderwoerd K, Lamers J, Sluiter W, Duncker D. Mitochondrial function: the heart of myocardial preservation. J. Lab. Clin. Med. 142, 141-148 (2003). (Pubitemid 37260466)
-
(2003)
Journal of Laboratory and Clinical Medicine
, vol.142
, Issue.3
, pp. 141-148
-
-
McFalls, E.O.1
Liem, D.2
Schoonderwoerd, K.3
Lamers, J.4
Sluiter, W.5
Duncker, D.6
-
10
-
-
0034623814
-
Cardiomyocyte apoptosis induced by Gaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway
-
Adams JW, Pagel AL, Means CK, Oksenberg D, Armstrong RC, Brown JH. Cardiomyocyte apoptosis induced by Gaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway. Circ. Res. 87, 1180-1187 (2000).
-
(2000)
Circ. Res.
, vol.87
, pp. 1180-1187
-
-
Adams, J.W.1
Pagel, A.L.2
Means, C.K.3
Oksenberg, D.4
Armstrong, R.C.5
Brown, J.H.6
-
11
-
-
38849156952
-
Heart mitochondria: Gates of life and death
-
Gustafsson AB, Gottlieb RA. Heart mitochondria: gates of life and death. Cardiovasc. Res. 77, 334-343 (2008).
-
(2008)
Cardiovasc. Res.
, vol.77
, pp. 334-343
-
-
Gustafsson, A.B.1
Gottlieb, R.A.2
-
12
-
-
10344242925
-
Kinase signaling cascades in the mitochondrion: A matter of life or death
-
DOI 10.1016/j.freeradbiomed.2004.09.030, PII S0891584904007567
-
Horbinski C, Chu CT. Kinase signaling cascades in the mitochondrion: a matter of life or death. Free Radic. Biol. Med. 38, 2-11 (2005). (Pubitemid 39626903)
-
(2005)
Free Radical Biology and Medicine
, vol.38
, Issue.1
, pp. 2-11
-
-
Horbinski, C.1
Chu, C.T.2
-
13
-
-
18844458509
-
The reperfusion injury salvage kinase pathway: A common target for both ischemic preconditioning and postconditioning
-
DOI 10.1016/j.tcm.2005.03.001, PII S1050173805000253
-
Hausenloy DJ, Tsang A, Yellon DM. The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc. Med. 15, 69-75 (2005). (Pubitemid 40693390)
-
(2005)
Trends in Cardiovascular Medicine
, vol.15
, Issue.2
, pp. 69-75
-
-
Hausenloy, D.J.1
Tsang, A.2
Yellon, D.M.3
-
15
-
-
0035196409
-
2 receptor-induced cardioprotection in guinea pig hearts
-
DOI 10.1006/jmcc.2001.1455
-
Li Y, Sato T. Dual signaling via protein kinase C and phosphatidylinositol 3′-kinase/ Akt contributes to bradykinin B2 receptorinduced cardioprotection in guinea pig hearts. J. Mol. Cell. Cardiol. 33, 2047-2053 (2001). (Pubitemid 33097282)
-
(2001)
Journal of Molecular and Cellular Cardiology
, vol.33
, Issue.11
, pp. 2047-2053
-
-
Li, Y.1
Sato, T.2
-
16
-
-
9144256765
-
Protein kinase Cd activation induces apoptosis in response to cardiac ischemia and reperfusion damage: A mechanism involving bad and the mitochondria
-
DOI 10.1074/jbc.M405071200
-
Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D. Protein kinase Cd activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J. Biol. Chem. 279, 47985-47991 (2004). (Pubitemid 39540950)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.46
, pp. 47985-47991
-
-
Murriel, C.L.1
Churchill, E.2
Inagaki, K.3
Szweda, L.I.4
Mochly-Rosen, D.5
-
17
-
-
57049135307
-
Ser9 phosphorylation of mitochondrial GSK-3β is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis
-
Ohori K, Miura T, Tanno M et al. Ser9 phosphorylation of mitochondrial GSK-3β is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis. Am. J. Physiol. Heart Circ. Physiol. 295, H2079-H2086 (2008).
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.295
-
-
Ohori, K.1
Miura, T.2
Tanno, M.3
-
18
-
-
33646116079
-
Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3b
-
Park SS, Zhao H, Mueller RA, Xu Z. Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3b. J. Mol. Cell. Cardiol. 40, 708-716 (2006).
-
(2006)
J. Mol. Cell. Cardiol.
, vol.40
, pp. 708-716
-
-
Park, S.S.1
Zhao, H.2
Mueller, R.A.3
Xu, Z.4
-
19
-
-
34047092224
-
Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways
-
DOI 10.1016/j.yjmcc.2007.01.004, PII S0022282807000065
-
Cohen MV, Philipp S, Krieg T et al. Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways. J. Mol. Cell. Cardiol. 42, 842-851 (2007). (Pubitemid 46527594)
-
(2007)
Journal of Molecular and Cellular Cardiology
, vol.42
, Issue.4
, pp. 842-851
-
-
Cohen, M.V.1
Philipp, S.2
Krieg, T.3
Cui, L.4
Kuno, A.5
Solodushko, V.6
Downey, J.M.7
-
20
-
-
42549124081
-
Essential role of lipid raft in ischemic preconditioning
-
DOI 10.1159/000129391
-
Das M, Gherghiceanu M, Lekli I, Mukherjee S, Popescu LM, Das DK. Essential role of lipid raft in ischemic preconditioning. Cell Physiol. Biochem. 21, 325-334 (2008). (Pubitemid 351591424)
-
(2008)
Cellular Physiology and Biochemistry
, vol.21
, Issue.4
, pp. 325-334
-
-
Das, M.1
Gherghiceanu, M.2
Lekli, I.3
Mukherjee, S.4
Popescu, L.M.5
Das, D.K.6
-
21
-
-
41149084540
-
Mapping preconditioning's signaling pathways: An engineering approach
-
Downey JM, Krieg T, Cohen MV. Mapping preconditioning's signaling pathways: an engineering approach. Ann. NY Acad. Sci. 1123, 187-196 (2008).
-
(2008)
Ann. NY Acad. Sci.
, vol.1123
, pp. 187-196
-
-
Downey, J.M.1
Krieg, T.2
Cohen, M.V.3
-
22
-
-
34547130863
-
The role of mitochondria in protection of the heart by preconditioning
-
Halestrap AP, Clarke SJ, Khaliulin I. The role of mitochondria in protection of the heart by preconditioning. Biochim. Biophys. Acta 1767, 1007-1031 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1767
, pp. 1007-1031
-
-
Halestrap, A.P.1
Clarke, S.J.2
Khaliulin, I.3
-
23
-
-
3042511840
-
Role Orf Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning
-
DOI 10.1161/01.CIR.0000130647.29030.90
-
Uchiyama T, Engelman RM, Maulik N, Das DK. Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning. Circulation 109, 3042-3049 (2004). (Pubitemid 38808327)
-
(2004)
Circulation
, vol.109
, Issue.24
, pp. 3042-3049
-
-
Uchiyama, T.1
Engelman, R.M.2
Maulik, N.3
Das, D.K.4
-
24
-
-
34447517344
-
Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation
-
DOI 10.1152/ajpheart.01098.2006
-
Zhang Y, Park TS, Gidday JM. Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation. Am. J. Physiol. Heart Circ. Physiol. 292, H2573-H2581 (2007). (Pubitemid 47084501)
-
(2007)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.292
, Issue.6
-
-
Zhang, Y.1
Park, T.S.2
Gidday, J.M.3
-
25
-
-
29144506087
-
IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes
-
DOI 10.1016/j.cardiores.2005.08.017, PII S0008636305004268
-
Smart N, Mojet MH, Latchman DS, Marber MS, Duchen MR, Heads RJ. IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovasc. Res. 69, 164-177 (2006). (Pubitemid 41814820)
-
(2006)
Cardiovascular Research
, vol.69
, Issue.1
, pp. 164-177
-
-
Smart, N.1
Mojet, M.H.2
Latchman, D.S.3
Marber, M.S.4
Duchen, M.R.5
Heads, R.J.6
-
26
-
-
33748030752
-
Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects
-
Smith CC, Mocanu MM, Davidson SM, Wynne AM, Simpkin JC, Yellon DM. Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects. Br. J. Pharmacol. 149, 5-13 (2006).
-
(2006)
Br. J. Pharmacol.
, vol.149
, pp. 5-13
-
-
Smith, C.C.1
Mocanu, M.M.2
Davidson, S.M.3
Wynne, A.M.4
Simpkin, J.C.5
Yellon, D.M.6
-
27
-
-
0142124776
-
Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway
-
Lai HC, Liu TJ, Ting CT, Sharma PM, Wang PH. Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway. Mol. Cell. Endocrinol. 205, 99-106 (2003).
-
(2003)
Mol. Cell. Endocrinol.
, vol.205
, pp. 99-106
-
-
Lai, H.C.1
Liu, T.J.2
Ting, C.T.3
Sharma, P.M.4
Wang, P.H.5
-
28
-
-
34347361680
-
Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen
-
DOI 10.1161/CIRCULATIONAHA.106.657981
-
Satoh M, Matter CM, Ogita H et al. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation 115, 3197-3204 (2007). (Pubitemid 47012234)
-
(2007)
Circulation
, vol.115
, Issue.25
, pp. 3197-3204
-
-
Satoh, M.1
Matter, C.M.2
Ogita, H.3
Takeshita, K.4
Wang, C.-Y.5
Dorn II, G.W.6
Liao, J.K.7
-
29
-
-
33845636194
-
Pharmacological postconditioning with the phytoestrogen genistein
-
Tissier R, Waintraub X, Couvreur N et al. Pharmacological postconditioning with the phytoestrogen genistein. J. Mol. Cell. Cardiol. 42, 79-87 (2007).
-
(2007)
J. Mol. Cell. Cardiol.
, vol.42
, pp. 79-87
-
-
Tissier, R.1
Waintraub, X.2
Couvreur, N.3
-
30
-
-
33845998883
-
Regulation of IGF-I receptor signaling in diabetic cardiac muscle: Dysregulation of cytosolic and mitochondria HSP60
-
Lai HC, Liu TJ, Ting CT et al. Regulation of IGF-I receptor signaling in diabetic cardiac muscle: dysregulation of cytosolic and mitochondria HSP60. Am. J. Physiol. Endocrinol. Metab. 292, E292-E297 (2007).
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.292
-
-
Lai, H.C.1
Liu, T.J.2
Ting, C.T.3
-
31
-
-
33744918504
-
ATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning
-
DOI 10.1152/ajpheart.00737.2005
-
Ahmad N, Wang Y, Haider KH et al. Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. Am. J. Physiol. Heart Circ. Physiol. 290, H2402-H2408 (2006). (Pubitemid 43846068)
-
(2006)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.290
, Issue.6
-
-
Ahmad, N.1
Wang, Y.2
Haider, K.H.3
Wang, B.4
Pasha, Z.5
Uzun, O.6
Ashraf, M.7
-
32
-
-
29244467695
-
Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection
-
DOI 10.1016/j.biocel.2005.09.017, PII S1357272505003043
-
Davidson SM, Hausenloy D, Duchen MR, Yellon DM. Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection. Int. J. Biochem. Cell Biol. 38, 414-419 (2006). (Pubitemid 41821888)
-
(2006)
International Journal of Biochemistry and Cell Biology
, vol.38
, Issue.3
, pp. 414-419
-
-
Davidson, S.M.1
Hausenloy, D.2
Duchen, M.R.3
Yellon, D.M.4
-
33
-
-
85047692700
-
Glycogen synthase kinase-3β mediates convergence of protection signalling to inhibit the mitochondrial permeability transition pore
-
DOI 10.1172/JCI200419906
-
Juhaszova M, Zorov DB, Kim SH et al. Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J. Clin. Invest. 113, 1535-1549 (2004). (Pubitemid 39071677)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.11
, pp. 1535-1549
-
-
Juhaszova, M.1
Zorov, D.B.2
Kim, S.-H.3
Pepe, S.4
Fu, Q.5
Fishbein, K.W.6
Ziman, B.D.7
Wang, S.8
Ytrehus, K.9
Antos, C.L.10
Olson, E.N.11
Sollott, S.J.12
-
34
-
-
42249101542
-
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening
-
Bhamra GS, Hausenloy DJ, Davidson SM et al. Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening. Basic Res. Cardiol. 103, 274-284 (2008).
-
(2008)
Basic Res. Cardiol.
, vol.103
, pp. 274-284
-
-
Bhamra, G.S.1
Hausenloy, D.J.2
Davidson, S.M.3
-
35
-
-
44249103783
-
Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion
-
DOI 10.1111/j.1440-1681.2008.04925.x
-
Kobayashi H, Miura T, Ishida H et al. Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion. Clin. Exp. Pharmacol. Physiol. 35, 812-819 (2008). (Pubitemid 351725241)
-
(2008)
Clinical and Experimental Pharmacology and Physiology
, vol.35
, Issue.7
, pp. 812-819
-
-
Kobayashi, H.1
Miura, T.2
Ishida, H.3
Miki, T.4
Tanno, M.5
Yano, T.6
Sato, T.7
Hotta, H.8
Shimamoto, K.9
-
36
-
-
39149138715
-
Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis
-
Nagy N, Malik G, Tosaki A, Ho YS, Maulik N, Das DK. Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis. J. Mol. Cell. Cardiol. 44, 252-260 (2008).
-
(2008)
J. Mol. Cell. Cardiol.
, vol.44
, pp. 252-260
-
-
Nagy, N.1
Malik, G.2
Tosaki, A.3
Ho, Y.S.4
Maulik, N.5
Das, D.K.6
-
37
-
-
41649100341
-
Txnip balances metabolic and growth signaling via PTEN disulfide reduction
-
Hui ST, Andres AM, Miller AK et al. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc. Natl Acad. Sci. USA 105, 3921-3926 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3921-3926
-
-
Hui, S.T.1
Andres, A.M.2
Miller, A.K.3
-
38
-
-
32844455654
-
Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway
-
DOI 10.1007/s00395-005-0566-z
-
Philipp S, Critz SD, Cui L, Solodushko V, Cohen MV, Downey JM. Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway. Basic Res. Cardiol. 101, 159-167 (2006). (Pubitemid 43250808)
-
(2006)
Basic Research in Cardiology
, vol.101
, Issue.2
, pp. 159-167
-
-
Philipp, S.1
Critz, St.D.2
Cui, L.3
Solodushko, V.4
Cohen, M.V.5
Downey, J.M.6
-
39
-
-
54049086214
-
Mitochondrial permeability transition pore opening inhibition by ecdysterone in heart mitochondria of aging rats
-
Sahach VF, Korkach Iu P, Kotsiuruba AV, Rudyk OV, Vavilova HL. [Mitochondrial permeability transition pore opening inhibition by ecdysterone in heart mitochondria of aging rats]. Fiziol. Zh. 54, 3-10 (2008).
-
(2008)
Fiziol. Zh.
, vol.54
, pp. 3-10
-
-
Sahach, V.F.1
Korkach Iu, P.2
Kotsiuruba, A.V.3
Rudyk, O.V.4
Vavilova, H.L.5
-
40
-
-
13844255495
-
Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes
-
DOI 10.1016/j.cardiores.2004.12.004
-
Xu Z, Park SS, Mueller RA, Bagnell RC, Patterson C, Boysen PG. Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. Cardiovasc. Res. 65, 803-812 (2005). (Pubitemid 40253575)
-
(2005)
Cardiovascular Research
, vol.65
, Issue.4
, pp. 803-812
-
-
Xu, Z.1
Park, S.-S.2
Mueller, R.A.3
Bagnell, R.C.4
Patterson, C.5
Boysen, P.G.6
-
41
-
-
0346434149
-
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation
-
Bijur GN, Jope RS. Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J. Neurochem. 87, 1427-1435 (2003).
-
(2003)
J. Neurochem.
, vol.87
, pp. 1427-1435
-
-
Bijur, G.N.1
Jope, R.S.2
-
42
-
-
0042733215
-
Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells
-
DOI 10.1074/jbc.M212167200
-
Sasaki K, Sato M, Umezawa Y. Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J. Biol. Chem. 278, 30945-30951 (2003). (Pubitemid 36994606)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.33
, pp. 30945-30951
-
-
Sasaki, K.1
Sato, M.2
Umezawa, Y.3
-
43
-
-
58149328569
-
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
-
Piantadosi CA, Carraway MS, Babiker A, Suliman HB. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ. Res. 103, 1232-1240 (2008).
-
(2008)
Circ. Res.
, vol.103
, pp. 1232-1240
-
-
Piantadosi, C.A.1
Carraway, M.S.2
Babiker, A.3
Suliman, H.B.4
-
44
-
-
36249002916
-
PKB and the mitochondria: AKTing on apoptosis
-
Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA. PKB and the mitochondria: AKTing on apoptosis. Cell Signal 20, 21-30 (2008).
-
(2008)
Cell Signal
, vol.20
, pp. 21-30
-
-
Parcellier, A.1
Tintignac, L.A.2
Zhuravleva, E.3
Hemmings, B.A.4
-
45
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell- Intrinsic death machinery
-
DOI 10.1016/S0092-8674(00)80405-5
-
Datta SR, Dudek H, Tao X et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997). (Pubitemid 27456390)
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Xu, T.3
Masters, S.4
Haian, F.5
Gotoh, Y.6
Greenberg, M.E.7
-
46
-
-
14244252655
-
Contribution of the PI 3-kinase/Akt survival pathway toward osmotic preconditioning
-
DOI 10.1007/s11010-005-2536-z
-
Pastukh V, Ricci C, Solodushko V, Mozaffari M, Schaffer SW. Contribution of the PI 3-kinase/Akt survival pathway toward osmotic preconditioning. Mol. Cell. Biochem. 269, 59-67 (2005). (Pubitemid 40287802)
-
(2005)
Molecular and Cellular Biochemistry
, vol.269
, Issue.1
, pp. 59-67
-
-
Pastukh, V.1
Ricci, C.2
Solodushko, V.3
Mozaffari, M.4
Schaffer, S.W.5
-
47
-
-
0141788738
-
Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion
-
Kato K, Yin H, Agata J, Yoshida H, Chao L, Chao J. Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion. Am. J. Physiol. Heart Circ. Physiol. 285, H1506-H1514 (2003). (Pubitemid 37169504)
-
(2003)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.285
, Issue.4
-
-
Kato, K.1
Yin, H.2
Agata, J.3
Yoshida, H.4
Chao, L.5
Chao, J.6
-
48
-
-
0035824907
-
Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling
-
Jonassen AK, Sack MN, Mjos OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ. Res. 89, 1191-1198 (2001).
-
(2001)
Circ. Res.
, vol.89
, pp. 1191-1198
-
-
Jonassen, A.K.1
Sack, M.N.2
Mjos, O.D.3
Yellon, D.M.4
-
49
-
-
0035970041
-
Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction
-
Negoro S, Oh H, Tone E et al. Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction. Circulation 103, 555-561 (2001). (Pubitemid 32116241)
-
(2001)
Circulation
, vol.103
, Issue.4
, pp. 555-561
-
-
Negoro, S.1
Oh, H.2
Tone, E.3
Kunisada, K.4
Fujio, Y.5
Walsh, K.6
Kishimoto, T.7
Yamauchi-Takihara, K.8
-
50
-
-
0033851183
-
Cardiotrophin-1 phosphorylates Akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes
-
DOI 10.1006/jmcc.2000.1177
-
Kuwahara K, Saito Y, Kishimoto I et al. Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes. J. Mol. Cell. Cardiol. 32, 1385-1394 (2000). (Pubitemid 30683408)
-
(2000)
Journal of Molecular and Cellular Cardiology
, vol.32
, Issue.8
, pp. 1385-1394
-
-
Kuwahara, K.1
Saito, Y.2
Kishimoto, I.3
Miyamoto, Y.4
Harada, M.5
Ogawa, E.6
Hamanaka, I.7
Kajiyama, N.8
Takahashi, N.9
Izumi, T.10
Kawakami, R.11
Nakao, K.12
-
51
-
-
33746278866
-
The modulation of inter-organelle cross-talk to control apoptosis
-
DOI 10.2174/157340606775197787
-
Le Bras M, Rouy I, Brenner C. The modulation of inter-organelle cross-talk to control apoptosis. Med. Chem. 2, 1-12 (2006). (Pubitemid 44101309)
-
(2006)
Medicinal Chemistry
, vol.2
, Issue.1
, pp. 1-12
-
-
Le Bras, M.1
Rouy, I.2
Brenner, C.3
-
52
-
-
25144439534
-
Mitochondrial hexokinases: Guardians of the mitochondria
-
Robey RB, Hay N. Mitochondrial hexokinases: guardians of the mitochondria. Cell Cycle 4, 654-658 (2005).
-
(2005)
Cell Cycle
, vol.4
, pp. 654-658
-
-
Robey, R.B.1
Hay, N.2
-
53
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
DOI 10.1038/sj.onc.1209595, PII 1209595
-
Robey RB, Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 25, 4683-4696 (2006). •• Excellent review of the interaction between Akt and hexokinase. (Pubitemid 44187618)
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
54
-
-
10644290828
-
On the InterAktion between hexokinase and the mitochondrion
-
Birnbaum MJ. On the InterAktion between hexokinase and the mitochondrion. Dev. Cell 7, 781-782 (2004).
-
(2004)
Dev. Cell
, vol.7
, pp. 781-782
-
-
Birnbaum, M.J.1
-
55
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
DOI 10.1016/j.molcel.2004.11.014, PII S1097276504006781
-
Majewski N, Nogueira V, Bhaskar P et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell 16, 819-830 (2004). (Pubitemid 39586539)
-
(2004)
Molecular Cell
, vol.16
, Issue.5
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
Chandel, N.S.7
Thompson, C.B.8
Robey, R.B.9
Hay, N.10
-
56
-
-
0347986675
-
Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases
-
DOI 10.1128/MCB.24.2.730-740.2004
-
Majewski N, Nogueira V, Robey RB, Hay N. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol. Cell. Biol. 24, 730-740 (2004). (Pubitemid 38057924)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.2
, pp. 730-740
-
-
Majewski, N.1
Nogueira, V.2
Robey, R.B.3
Hay, N.4
-
57
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
DOI 10.1101/gad.889901
-
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev. 15, 1406-1418 (2001). (Pubitemid 32524647)
-
(2001)
Genes and Development
, vol.15
, Issue.11
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
58
-
-
39449114808
-
Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II
-
DOI 10.1038/sj.cdd.4402285, PII 4402285
-
Miyamoto S, Murphy AN, Brown JH. Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. Cell Death Differ. 15(3), 521-529 (2008). •• Demonstrates the role of hexokinase in cardiomyocyte protective signaling downstream of Akt. (Pubitemid 351267303)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.3
, pp. 521-529
-
-
Miyamoto, S.1
Murphy, A.N.2
Brown, J.H.3
-
59
-
-
33646458252
-
Akt signaling and growth of the heart
-
Walsh K. Akt signaling and growth of the heart. Circulation 113, 2032-2034 (2006).
-
(2006)
Circulation
, vol.113
, pp. 2032-2034
-
-
Walsh, K.1
-
60
-
-
1842830427
-
Nuclear Targetin of Akt Enhances Kinase Activity and Survival of Cardiomyocytes
-
DOI 10.1161/01.RES.0000124394.01180.BE
-
Shiraishi I, Melendez J, Ahn Y et al. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ. Res. 94, 884-891 (2004). (Pubitemid 38490065)
-
(2004)
Circulation Research
, vol.94
, Issue.7
, pp. 884-891
-
-
Shiraishi, I.1
Melendez, J.2
Ahn, Y.3
Skavdahl, M.4
Murphy, E.5
Welch, S.6
Schaefer, E.7
Walsh, K.8
Rosenzweig, A.9
Torella, D.10
Nurzynska, D.11
Kajstura, J.12
Leri, A.13
Anversa, P.14
Sussman, M.A.15
-
61
-
-
0034651983
-
Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart
-
Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101, 660-667 (2000). (Pubitemid 30094738)
-
(2000)
Circulation
, vol.101
, Issue.6
, pp. 660-667
-
-
Fujio, Y.1
Nguyen, T.2
Wencker, D.3
Kitsis, R.N.4
Walsh, K.5
-
62
-
-
29344463277
-
Structure and substrate specificity of the Pim-1 kinase
-
DOI 10.1074/jbc.M510711200
-
Bullock AN, Debreczeni J, Amos AL, Knapp S, Turk BE. Structure and substrate specificity of the Pim-1 kinase. J. Biol. Chem. 280, 41675-41682 (2005). (Pubitemid 43000572)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.50
, pp. 41675-41682
-
-
Bullock, A.N.1
Debreczeni, J.2
Amos, A.L.3
Knapp, S.4
Turk, B.E.5
-
63
-
-
0025866176
-
Recombinant human pim-1 protein exhibits serine/threonine kinase activity
-
Hoover D, Friedmann M, Reeves R, Magnuson NS. Recombinant human Pim-1 protein exhibits serine/threonine kinase activity. J. Biol. Chem. 266, 14018-14023 (1991). (Pubitemid 21907455)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.21
, pp. 14018-14023
-
-
Hoover, D.1
Friedmann, M.2
Reeves, R.3
Magnuson, N.S.4
-
64
-
-
0035754569
-
Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis
-
Wang Z, Bhattacharya N, Weaver M et al. Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis. J. Vet. Sci. 2, 167-179 (2001).
-
(2001)
J. Vet. Sci.
, vol.2
, pp. 167-179
-
-
Wang, Z.1
Bhattacharya, N.2
Weaver, M.3
-
66
-
-
0022002134
-
Oncogene expression in murine splenic T cells and in murine T-cell neoplasms
-
DOI 10.1016/0042-6822(85)90310-1
-
Mally MI, Vogt M, Swift SE, Haas M. Oncogene expression in murine splenic T cells and in murine T-cell neoplasms. Virology 144, 115-126 (1985). (Pubitemid 15226175)
-
(1985)
Virology
, vol.144
, Issue.1
, pp. 115-126
-
-
Mally, M.I.1
Vogt, M.2
Swift, S.E.3
Haas, M.4
-
67
-
-
0022552647
-
Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias
-
Nagarajan L, Louie E, Tsujimoto Y, ar-Rushdi A, Huebner K, Croce CM. Localization of the human Pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias. Proc. Natl Acad. Sci. USA 83, 2556-2560 (1986). (Pubitemid 16026921)
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, Issue.8
, pp. 2556-2560
-
-
Nagarajan, L.1
Louie, E.2
Tsujimoto, Y.3
-
68
-
-
0023610154
-
Characterization of the human PIM-1 gene: A putative proto-oncogene coding for a tissue specific member of the protein kinase family
-
Meeker TC, Nagarajan L, ar-Rushdi A, Rovera G, Huebner K, Croce CM. Characterization of the human PIM-1 gene: a putative proto-oncogene coding for a tissue specific member of the protein kinase family. Oncogene Res. 1, 87-101 (1987). (Pubitemid 18041730)
-
(1987)
Oncogene Research
, vol.1
, Issue.1
, pp. 87-101
-
-
Meeker, T.C.1
Nagarajan, L.2
Ar-Rushdi, A.3
Rovera, G.4
Huebner, K.5
Croce, C.M.6
-
69
-
-
0028875479
-
Differentiationassociated expression of the proto-oncogene Pim-1 in cultured human keratinocytes
-
Stewart BE, Rice RH. Differentiationassociated expression of the proto-oncogene Pim-1 in cultured human keratinocytes. J. Invest. Dermatol. 105, 699-703 (1995).
-
(1995)
J. Invest. Dermatol.
, vol.105
, pp. 699-703
-
-
Stewart, B.E.1
Rice, R.H.2
-
70
-
-
0029943649
-
Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1
-
DOI 10.1006/abbi.1996.0251
-
Liang H, Hittelman W, Nagarajan L. Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1. Arch. Biochem. Biophys. 330, 259-265 (1996). (Pubitemid 126335185)
-
(1996)
Archives of Biochemistry and Biophysics
, vol.330
, Issue.2
, pp. 259-265
-
-
Liang, H.1
Hittelman, W.2
Nagarajan, L.3
-
71
-
-
0033809719
-
The Pim-1 kinase stimulates maturation of TCRβ-deficient T cell progenitors: Implications for the mechanism of Pim-1 action
-
Leduc I, Karsunky H, Mathieu N et al. The Pim-1 kinase stimulates maturation of TCRβ-deficient T cell progenitors: implications for the mechanism of Pim-1 action. Int. Immunol. 12, 1389-1396 (2000). (Pubitemid 30763269)
-
(2000)
International Immunology
, vol.12
, Issue.10
, pp. 1389-1396
-
-
Leduc, I.1
Karsunky, H.2
Mathieu, N.3
Schmidt, T.4
Verthuy, C.5
Ferrier, P.6
Moroy, T.7
-
72
-
-
0141569009
-
Myc-driven murine prostate cancer shares molecular features with human prostate tumors
-
DOI 10.1016/S1535-6108(03)00197-1
-
Ellwood-Yen K, Graeber TG, Wongvipat J et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 4, 223-238 (2003). (Pubitemid 37163836)
-
(2003)
Cancer Cell
, vol.4
, Issue.3
, pp. 223-238
-
-
Ellwood-Yen, K.1
Graeber, T.G.2
Wongvipat, J.3
Iruela-Arispe, M.L.4
Zhang, J.5
Matusik, R.6
Thomas, G.V.7
Sawyers, C.L.8
-
73
-
-
19944427008
-
Role of Pim-1 in smooth muscle cell proliferation
-
DOI 10.1074/jbc.M409140200
-
Katakami N, Kaneto H, Hao H et al. Role of Pim-1 in smooth muscle cell proliferation. J. Biol. Chem. 279, 54742-54749 (2004). (Pubitemid 40053219)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.52
, pp. 54742-54749
-
-
Katakami, N.1
Kaneto, H.2
Hao, H.3
Umayahara, Y.4
Fujitani, Y.5
Sakamoto, K.6
Gorogawa, S.-I.7
Yasuda, T.8
Kawamori, D.9
Kajimoto, Y.10
Matsuhisa, M.11
Yutani, C.12
Hori, M.13
Yamasaki, Y.14
-
74
-
-
0033560095
-
Interferon-α activates multiple STAT proteins and upregulates proliferationassociated IL-2Rα, c-myc, and Pim-1 genes in human T cells
-
Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ, Julkunen I. Interferon-α activates multiple STAT proteins and upregulates proliferationassociated IL-2Rα, c-myc, and Pim-1 genes in human T cells. Blood 93, 1980-1991 (1999).
-
(1999)
Blood
, vol.93
, pp. 1980-1991
-
-
Matikainen, S.1
Sareneva, T.2
Ronni, T.3
Lehtonen, A.4
Koskinen, P.J.5
Julkunen, I.6
-
75
-
-
9244243110
-
STATs as critical mediators of signal transduction and transcription: Lessons learned from STAT5
-
DOI 10.1016/j.cytogfr.2004.09.001, PII S1359610104000759
-
Paukku K, Silvennoinen O. STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5. Cytokine Growth Factor Rev. 15, 435-455 (2004). (Pubitemid 39550454)
-
(2004)
Cytokine and Growth Factor Reviews
, vol.15
, Issue.6
, pp. 435-455
-
-
Paukku, K.1
Silvennoinen, O.2
-
76
-
-
8444247043
-
IL-5 and granulocytemacrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils
-
Stout BA, Bates ME, Liu LY, Farrington NN, Bertics PJ. IL-5 and granulocytemacrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils. J. Immunol. 173, 6409-6417 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 6409-6417
-
-
Stout, B.A.1
Bates, M.E.2
Liu, L.Y.3
Farrington, N.N.4
Bertics, P.J.5
-
77
-
-
0037319183
-
Prolactin-regulated pim-1 transcription: Identification of critical promoter elements and Akt signaling
-
DOI 10.1385/ENDO:20:1-2:123
-
Krishnan N, Pan H, Buckley DJ, Buckley A. Prolactin-regulated Pim-1 transcription: identification of critical promoter elements and Akt signaling. Endocrine 20, 123-130 (2003). (Pubitemid 36515196)
-
(2003)
Endocrine
, vol.20
, Issue.1-2
, pp. 123-129
-
-
Krishnan, N.1
Pan, H.2
Buckley, D.J.3
Buckley, A.R.4
-
78
-
-
3343007095
-
112 gatekeeper site
-
DOI 10.1016/j.febslet.2004.06.050, PII S0014579304008026
-
Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ. Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett. 571, 43-49 (2004). (Pubitemid 38992921)
-
(2004)
FEBS Letters
, vol.571
, Issue.1-3
, pp. 43-49
-
-
Aho, T.L.T.1
Sandholm, J.2
Peltola, K.J.3
Mankonen, H.P.4
Lilly, M.5
Koskinen, P.J.6
-
79
-
-
0242580961
-
The PIM-2 Kinase Phosphorylates BAD on Serine 112 and Reverses BAD-induced Cell Death
-
DOI 10.1074/jbc.M307933200
-
Yan B, Zemskova M, Holder S et al. The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J. Biol. Chem. 278, 45358-45367 (2003). (Pubitemid 37432672)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.46
, pp. 45358-45367
-
-
Yan, B.1
Zemskova, M.2
Holder, S.3
Chin, V.4
Kraft, A.5
Koskinen, P.J.6
Lilly, M.7
-
80
-
-
26444448463
-
The survival kinases Akt and Pim as potential pharmacological targets
-
DOI 10.1172/JCI26273
-
Amaravadi R, Thompson CB. The survival kinases Akt and Pim as potential pharmacological targets. J. Clin. Invest. 115, 2618-2624 (2005). (Pubitemid 41434384)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2618-2624
-
-
Amaravadi, R.1
Thompson, C.B.2
-
81
-
-
19344374597
-
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
-
Defines the synergistic relationship between Akt and Pim-1 signaling in the hematopoetic context.
-
Hammerman PS, Fox CJ, Birnbaum MJ, Thompson CB. Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood 105, 4477-4483 (2005). •• Defines the synergistic relationship between Akt and Pim-1 signaling in the hematopoetic context.
-
(2005)
Blood
, vol.105
, pp. 4477-4483
-
-
Hammerman, P.S.1
Fox, C.J.2
Birnbaum, M.J.3
Thompson, C.B.4
-
82
-
-
17144422830
-
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002
-
DOI 10.1074/jbc.M413155200
-
Jacobs MD, Black J, Futer O et al. Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J. Biol. Chem. 280, 13728-13734 (2005). (Pubitemid 40517268)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13728-13734
-
-
Jacobs, M.D.1
Black, J.2
Futer, O.3
Swenson, L.4
Hare, B.5
Fleming, M.6
Saxena, K.7
-
83
-
-
14044266297
-
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
-
DOI 10.1074/jbc.M411534200
-
Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J. Biol. Chem. 280, 5581-5587 (2005). (Pubitemid 40280036)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 5581-5587
-
-
Kunkel, M.T.1
Ni, Q.2
Tsien, R.Y.3
Zhang, J.4
Newton, A.C.5
-
84
-
-
0035947744
-
Myocardial Akt activation and gender: Increased nuclear activity in females versus males
-
Camper-Kirby D, Welch S, Walker A et al. Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ. Res. 88, 1020-1027 (2001). (Pubitemid 34137114)
-
(2001)
Circulation Research
, vol.88
, Issue.10
, pp. 1020-1027
-
-
Camper-Kirby, D.1
Welch, S.2
Walker, A.3
Shiraishi, I.4
Setchell, K.D.R.5
Schaefer, E.6
Kajstura, J.7
Anversa, P.8
Sussman, M.A.9
-
85
-
-
36849037512
-
Pim-1 regulates cardiomyocyte survival downstream of Akt
-
DOI 10.1038/nm1671, PII NM1671
-
Muraski JA, Rota M, Misao Y et al. Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat. Med. 13, 1467-1475 (2007). •• Demonstrates that the cardioprotective effect of Akt kinase depends upon the induction of Pim-1. (Pubitemid 350224243)
-
(2007)
Nature Medicine
, vol.13
, Issue.12
, pp. 1467-1475
-
-
Muraski, J.A.1
Rota, M.2
Misao, Y.3
Fransioli, J.4
Cottage, C.5
Gude, N.6
Esposito, G.7
Delucchi, F.8
Arcarese, M.9
Alvarez, R.10
Siddiqi, S.11
Emmanuel, G.N.12
Wu, W.13
Fischer, K.14
Martindale, J.J.15
Glembotski, C.C.16
Leri, A.17
Kajstura, J.18
Magnuson, N.19
Berns, A.20
Beretta, R.M.21
Houser, S.R.22
Schaefer, E.M.23
Anversa, P.24
Sussman, M.A.25
more..
-
86
-
-
52949116043
-
Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload
-
Muraski JA, Fischer KM, Wu W et al. Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc. Natl Acad. Sci. USA 105, 13889-13894 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 13889-13894
-
-
Muraski, J.A.1
Fischer, K.M.2
Wu, W.3
-
87
-
-
0042626302
-
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
-
Fox CJ, Hammerman PS, Cinalli RM, Master SR, Chodosh LA, Thompson CB. The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev. 17, 1841-1854 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 1841-1854
-
-
Fox, C.J.1
Hammerman, P.S.2
Cinalli, R.M.3
Master, S.R.4
Chodosh, L.A.5
Thompson, C.B.6
-
88
-
-
33746471790
-
Constitutively activated FLT3 phosphorylates BAD partially through Pim-1
-
DOI 10.1111/j.1365-2141.2006.06225.x
-
Kim KT, Levis M, Small D. Constitutively activated FLT3 phosphorylates BAD partially through Pim-1. Br. J. Haematol. 134, 500-509 (2006). (Pubitemid 44141716)
-
(2006)
British Journal of Haematology
, vol.134
, Issue.5
, pp. 500-509
-
-
Kim, K.-T.1
Levis, M.2
Small, D.3
-
89
-
-
0033536203
-
The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway
-
DOI 10.1038/sj.onc.1202741
-
Lilly M, Sandholm J, Cooper JJ, Koskinen PJ, Kraft A. The PIM-1 serine kinase prolongs survival and inhibits apoptosisrelated mitochondrial dysfunction in part through a bcl-2-dependent pathway. Oncogene 18, 4022-4031 (1999). •• Details the anti-apoptotic effect of Pim-1 kinase via antagonizing intrinsic apoptotic cascade signaling. (Pubitemid 29361341)
-
(1999)
Oncogene
, vol.18
, Issue.27
, pp. 4022-4031
-
-
Lilly, M.1
Sandholm, J.2
Cooper, J.J.3
Koskinen, P.J.4
Kraft, A.5
-
90
-
-
0037125980
-
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
-
Condorelli G, Drusco A, Stassi G et al. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc. Natl Acad. Sci. USA 99, 12333-12338 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 12333-12338
-
-
Condorelli, G.1
Drusco, A.2
Stassi, G.3
-
91
-
-
0037151104
-
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
-
DOI 10.1074/jbc.M200347200
-
Matsui T, Li L, Wu JC, Cook SA et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J. Biol. Chem. 277, 22896-22901 (2002). (Pubitemid 34967272)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.25
, pp. 22896-22901
-
-
Matsui, T.1
Li, N.2
Wu, J.C.3
Cook, S.A.4
Nagoshi, T.5
Picard, M.H.6
Liao, R.7
Rosenzweig, A.8
-
93
-
-
23644442091
-
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
-
DOI 10.1172/JCI23073
-
Nagoshi T, Matsui T, Aoyama T et al. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J. Clin. Invest. 115, 2128-2138 (2005). (Pubitemid 41134154)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.8
, pp. 2128-2138
-
-
Nagoshi, T.1
Matsui, T.2
Aoyama, T.3
Leri, A.4
Anversa, P.5
Li, L.6
Ogawa, W.7
Del Monte, F.8
Gwathmey, J.K.9
Grazette, L.10
Hemmings, B.11
Kass, D.A.12
Champion, H.C.13
Rosenzweig, A.14
-
94
-
-
23644439061
-
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
-
DOI 10.1172/JCI24682
-
Shiojima I, Sato K, Izumiya Y et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115, 2108-2118 (2005). (Pubitemid 41134152)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.8
, pp. 2108-2118
-
-
Shiojima, I.1
Sato, K.2
Izumiya, Y.3
Schiekofer, S.4
Ito, M.5
Liao, R.6
Colucci, W.S.7
Walsh, K.8
-
95
-
-
0036200937
-
Akt/protein kinase B promotes organ growth in transgenic mice
-
DOI 10.1128/MCB.22.8.2799-2809.2002
-
Shioi T, McMullen JR, Kang PM et al. Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22, 2799-2809 (2002). (Pubitemid 34263000)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.8
, pp. 2799-2809
-
-
Shioi, T.1
McMullen, J.R.2
Kang, P.M.3
Douglas, P.S.4
Obata, T.5
Franke, T.F.6
Cantley, L.C.7
Izumo, S.8
-
97
-
-
42049092501
-
Mitochondrial dynamics: To be in good shape to survive
-
Herzig S, Martinou JC. Mitochondrial dynamics: to be in good shape to survive. Curr. Mol. Med. 8, 131-137 (2008).
-
(2008)
Curr. Mol. Med.
, vol.8
, pp. 131-137
-
-
Herzig, S.1
Martinou, J.C.2
-
98
-
-
45349089531
-
Molecular machinery of mitochondrial fusion and fission
-
Westermann B. Molecular machinery of mitochondrial fusion and fission. J. Biol. Chem. 283, 13501-13505 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 13501-13505
-
-
Westermann, B.1
-
99
-
-
45449111156
-
Mitochondrial fission and fusion dynamics: The long and short of it
-
Berman SB, Pineda FJ, Hardwick JM. Mitochondrial fission and fusion dynamics: the long and short of it. Cell Death Differ. 15, 1147-1152 (2008).
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1147-1152
-
-
Berman, S.B.1
Pineda, F.J.2
Hardwick, J.M.3
-
100
-
-
34250828456
-
Mitophagy: Growing in intricacy
-
Devenish RJ. Mitophagy: growing in intricacy. Autophagy 3, 293-294 (2007).
-
(2007)
Autophagy
, vol.3
, pp. 293-294
-
-
Devenish, R.J.1
-
101
-
-
16844366524
-
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
-
Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. 8, 3-5 (2005).
-
(2005)
Rejuvenation Res.
, vol.8
, pp. 3-5
-
-
Lemasters, J.J.1
-
102
-
-
33846252817
-
Different fates of mitochondria: Alternative ways for degradation?
-
Mijaljica D, Prescott M, Devenish RJ. Different fates of mitochondria: alternative ways for degradation? Autophagy 3, 4-9 (2007). (Pubitemid 46100702)
-
(2007)
Autophagy
, vol.3
, Issue.1
, pp. 4-9
-
-
Mijaljica, D.1
Prescott, M.2
Devenish, R.J.3
-
103
-
-
67449156064
-
Nuclear and mitochondrial signalling Akts in cardiomyocytes
-
Miyamoto S, Rubio M, Sussman MA. Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc. Res. 82(2), 272-285 (2009).
-
(2009)
Cardiovasc. Res.
, vol.82
, Issue.2
, pp. 272-285
-
-
Miyamoto, S.1
Rubio, M.2
Sussman, M.A.3
-
104
-
-
0043127142
-
The Pims and outs of survival signaling: Role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
-
White E. The Pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines. Genes Dev. 17, 1813-1816 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 1813-1816
-
-
White, E.1
|