Integrating genetics and social science: Genetic risk scores

Biodemography and Social Biology

Volumn 60, Issue 2, 2014, Pages 137-155

  Belsky, Daniel W ^a,b   Israel, Salomon ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECONOMICS; GENETIC PREDISPOSITION; GENETICS; GENOME; HUMAN; PROCEDURES; RISK FACTOR; SOCIOLOGY;

GENETIC PREDISPOSITION TO DISEASE; GENETICS; GENOME; HUMANS; RISK FACTORS; SOCIAL SCIENCES;

EID: 84908476878     PISSN: 19485565     EISSN: 19485573     Source Type: Journal    
DOI: 10.1080/19485565.2014.946591     Document Type: Article

References (112)

1. Ahmad, S., G. Rukh, T.V. Varga, A. Ali, A. Kurbasic, D. Shungin, U. Ericson, et al. 2013. Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet 9(7): e1003607.
2. Asghari, V., S. Sanyal, S. Buchwaldt, A. Paterson, V. Jovanovic, and H. H. M. Van Tol. 1995. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 65(3): 1157-1165.
3. Aulchenko, Y. S., S. Ripke, A. Isaacs, and C. M. van Duijn. 2007. GenABEL: an R library for genome-wide association analysis. Bioinformatics 23(10): 1294-1296.
4. Belsky, D. W. 2014. Appetite for prevention: genetics and developmental epidemiology join forces in obesity research. JAMA Pediatr 168(4): 309-311.
5. Belsky, D. W., T. E. Moffitt, T. B. Baker, A. K. Biddle, J. P. Evans, H. Harrington, R. Houts, et al. 2013. Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. JAMA Psychiatry 70(5: 534-542.
6. Belsky, D.W., T. E. Moffitt, and A. Caspi. 2013. Genetics in population health science: strategies and opportunities. Am J Public Health 103(suppl 1): S73-S83.
7. Belsky, D. W., T. E. Moffitt, R. Houts, G. G. Bennett, A. K. Biddle, J. A. Blumenthal, J. P. Evans, et al. 2012. Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Arch Pediatr Adolesc Med 166(6): 515-521.
8. Belsky, D. W., T. E. Moffitt, K. Sugden, B. Williams, R. Houts, J. McCarthy, and A. Caspi. 2013. Development and evaluation of a genetic risk score for obesity. Biodemography Soc Biol 59(1): 85-100.
9. Belsky, D. W., M. R. Sears, R. J. Hancox, H. Harrington, R. Houts, T. E. Moffitt, K. Sugden, B. Williams, R. Poulton, and A. Caspi. 2013. Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study. Lancet Respir Med 1(6): 453-461.
10. Benjamin, D. J., D. Cesarini, M. J. H. M. van der Loos, C. T. Dawes, P. D. Koellinger, P. K. E. Magnusson, C. F. Chabris, et al. 2012. The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A 109(21): 8026-8031.
11. Boardman, J. D., B. W. Domingue, C. L. Blalock, B. C. Haberstick, K. M. Harris, and M. B. McQueen. 2014. Is the gene-environment interaction paradigm relevant to genomewide studies? The case of education and body mass index. Demography 51(1): 119-139. doi: 10.1007/s13524-013-0259-4
12. Boardman, J. D., B. W. Domingue, and J. M. Fletcher. 2012. How social and genetic factors predict friendship networks. Proc Natl Acad Sci U S A 109 (43): 17,377-17,381.
13. Bogdan, R., L. W. Hyde, and A. R. Hariri. 2013. A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology. Mol Psychiatry 18(3): 288-299.
14. Bush, W. S., and J. H. Moore. 2012. Genome-wide association studies. PLoS Comput Biol 8(12): e1002822.
15. Cardon, L. R., and L. J. Palmer. 2003. Population stratification and spurious allelic association. Lancet 361(9357): 598-604.
16. Carey, J. R., and J. W. Vaupel. 2005. Biodemography. In Handbook of population, ed. D. L. Poston and M. Micklin, 625-658. Handbooks of Sociology and Social Research. New York: Springer US.
17. Chiao, J. Y., and K. D. Blizinsky. 2010. Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene. Proc R Soc B Biol Sci 277(1681): 529-537.
18. Christakis, N. A., and J. H. Fowler. 2014. Friendship and natural selection. Proc Natl Acad Sci 111 Suppl 3 (July): 10796-10801. doi: 10.1073/pnas.1400825111
19. Collier, D. A., G. Stöber, T. Li, A. Heils, M. Catalano, D. Di Bella, M. J. Arranz, et al. 1996. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1(6): 453-460.
20. Conley, D., M. L. Siegal, B. Domingue, K. Mulan Harris, M. McQueen, and J. Boardman. 2014. Testing the key assumption of heritability estimates based on genome-wide genetic relatedness. J Hum Genet 59: 342-345.
21. Crimmins, E., J. K. Kim, and S. Vasunilashorn. 2010. Biodemography: new approaches to understanding trends and differences in population health and mortality. Demography 47(suppl. 1): S41-S64.
22. David, S. P., D. R. Strong, A. M. Leventhal, M. A. Lancaster, J. E. McGeary, M. R. Munafò, A. W. Bergen, et al. 2013. Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. Addiction 108(12): 2202-2211.
23. Demerath, E. W., A. C. Choh, W. Johnson, J. E. Curran, M. Lee, C. Bellis, T. D. Dyer, S. A. Czerwinski, J. Blangero, and B. Towne. 2013. The positive association of obesity variants with adulthood adiposity strengthens over an 80-year period: a gene-by-birth year interaction. Hum Hered 75(2-4): 175-185.
24. Demirkan, A., B. W. J. H. Penninx, K. Hek, N. R. Wray, N. Amin, Y. S. Aulchenko, R. van Dyck, et al. 2011. Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Mol Psychiatry 16(7): 773-783.
25. Domingue, B. W., D. W. Belsky, K. M. Harris, A. Smolen, M. B. McQueen, and J. D. Boardman. 2014. Polygenic risk predicts obesity in both white and black young adults. PLoS ONE 9(7: e101596.
26. Domingue, B. W., J. Fletcher, D. Conley, and J. D. Boardman. 2014. Genetic and educational assortative mating among US adults. Proc Natl Acad Sci 111(22): 7996-8000. doi: 10.1073/pnas.1321426111
27. Dudbridge, F. 2013. Power and predictive accuracy of polygenic risk scores. PLoS Genet 9(3): e1003348.
28. Evans, D. M., P. M. Visscher, and N. R. Wray. 2009. Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum Mol Genet 18(18): 3525-3531.
29. Fletcher, J. M. 2012. Why have tobacco control policies stalled? Using genetic moderation to examine policy impacts. PloS One 7(12): e50576.
30. Fletcher, J. M., and D. Conley. 2013. The challenge of causal inference in gene-environment interaction research: leveraging research designs from the social sciences. Am J Public Health 103(suppl. 1): S42-S45.
31. Flint, J., and K. S. Kendler. 2014. The genetics of major depression. Neuron 81(3): 484-503.
32. Forsberg, L. A., D. Absher, and J. P. Dumanski. 2013. Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime. J Med Genet 50(1): 1-10.
33. Fowler, J. H., J. E. Settle, and N. A. Christakis. 2011. Correlated genotypes in friendship networks. Proc Natl Acad Sci 108(5): 1993-1997.
34. Frazer, K. A., D. G. Ballinger, D. R. Cox, D. A. Hinds, L. L. Stuve, R. A. Gibbs, J. W. Belmont, et al. 2007. A second generation human haplotype map of over 3.1 million SNPs. Nature 449(7164): 851-861.
35. Ganna, A., P. K. E. Magnusson, N. L. Pedersen, U. de Faire, M. Reilly, J. Arnlöv, J. Sundström, A. Hamsten, and E. Ingelsson. 2013. Multilocus genetic risk scores for coronary heart disease prediction. Arterioscler Thromb Vasc Biol 33(9): 2267-2272. doi: 10.1161/ATVBAHA.113.301218
36. Gibson, G. 2011. Rare and common variants: twenty arguments. Nat Rev Genet 13(2): 135-145.
37. Gómez, J. E., B. A. Johnson, M. Selva, and J.F. Sallis. 2004. Violent crime and outdoor physical activity among inner-city youth. Prev Med 39(5): 876-881.
38. Gordon-Larsen, P., M. C. Nelson, P. Page, and B. M. Popkin. 2006. Inequality in the built environment underlies key health disparities in physical activity and obesity. Pediatrics 117(2): 417-424.
39. Hamer, D., and L. Sirota. 2000. Beware the chopsticks gene. Mol Psychiatry 5(1): 11-13.
40. Hariri, A. R. 2009. The neurobiology of individual differences in complex behavioral traits. Annu Rev Neurosci 32: 225-247.
41. Herbert, A., N. P. Gerry, M. B. McQueen, I. M. Heid, A. Pfeufer, T. Illig, H. E. Wichmann, et al. 2006. A common genetic variant is associated with adult and childhood obesity. Science 312: 279-283.
42. Hindorff, L. A., H. A. Junkins, J. P. Mehta, and T. A. Manolio. n.d. A catalog of published genomewide association studies. Accessed August 18, 2014, at http://www.genome.gov/gwastudies/.
43. Hindorff, L. A., P. Sethupathy, H. A. Junkins, E. M. Ramos, J. P. Mehta, F. S. Collins, and T. A. Manolio. 2009. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106: 9362-9367.
44. Hirschhorn, J. N., and M. J. Daly. 2005. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6(2): 95-108.
45. Hunter, D. J., and P. Kraft. 2007. Drinking from the fire hose-statistical issues in genomewide association studies. N Engl J Med 357: 436-439.
46. Hyman, S. E., R. C. Malenka, and E. J. Nestler. 2006. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29(1): 565-598.
47. Israel, S., E. Lerer, I. Shalev, F. Uzefovsky, M. Riebold, E. Laiba, R. Bachner-Melman, et al. 2009. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PloS One 4(5): e5535.
48. Israel, S., T. E. Moffitt, D.W. Belsky, R. J. Hancox, R. Poulton, B. Roberts, W. Murray, and A. Caspi. 2014. Translating personality psychology to help personalize preventive medicine for young adult patients. J Pers Soc Psychol 106(3): 484-498.
49. Jakobsdottir, J., M. B. Gorin, Y. P. Conley, R. E. Ferrell, and D. E. Weeks. 2009. Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers. PLoS Genet 5(2): e1000337.
50. Jokela, M., G. D. Batty, I. J. Deary, K. Silventoinen, and M. Kivimäki. 2011. Sibling analysis of adolescent intelligence and chronic diseases in older adulthood. Ann Epidemiol 21(7): 489-496.
51. Kathiresan, S., O. Melander, D. Anevski, C. Guiducci, N. P. Burtt, C. Roos, J. N. Hirschhorn, et al. 2008. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med 358(12): 1240-1249.
52. Kilpelainen, T. O., L. Qi, S. Brage, S. J. Sharp, E. Sonestedt, E. Demerath, T. Ahmad, et al. 2011. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 8: e1001116.
53. Kim, H. S., D. K. Sherman, J. Y. Sasaki, J. Xu, T.Q. Chu, C. Ryu, E. M. Suh, K. Graham, and S. E. Taylor. 2010. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc Natl Acad Sci 107 (36): 15,717-15,721.
54. Koob, G. F., and N. D. Volkow. 2010. Neurocircuitry of addiction. Neuropsychopharmacology 35: 217-238.
55. Kraft, P., S. Wacholder, M. Cornelis, F. B. Hu, R. B. Hayes, G. Thomas, R. Hoover, D. J. Hunter, and S. Chanock. 2009. Beyond odds ratios-communicating disease risk based on genetic profiles. Nat Rev Genet 10: 264-269.
56. Lango Allen, H., K. Estrada, G. Lettre, S. I. Berndt, M. N. Weedon, F. Rivadeneira, C. J. Willer, et al. 2010. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467: 832-838.
57. Laurie, C. C., K. F. Doheny, D. B. Mirel, E. W. Pugh, L. J. Bierut, T. Bhangale, F. Boehm, et al. 2010. Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol 34(6): 591-602.
58. Lencz, T., E. Knowles, G. Davies, S. Guha, D. C. Liewald, J. M. Starr, S. Djurovic, et al. 2014. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consor Tium (COGENT). Mol Psychiatry 19(2): 168-174.
59. Lesch, K. P., D. Bengel, A. Heils, S. Z. Sabol, B. D. Greenberg, S. Petri, J. Benjamin, C. R. Muller, D. H. Hamer, and D. L. Murphy. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
60. Li, S., J. H. Zhao, J. Luan, U. Ekelund, R. N. Luben, K.-T. Khaw, N. J. Wareham, and R. J. F. Loos. 2010. Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk Prospective Population Study. PLoS Med 7(8): 1-9.
61. Li, X., G. A. Hawkins, E. J. Ampleford, W. C. Moore, H. Li, A. T. Hastie, T. D. Howard, et al. 2013. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol 132(2): 313-320e15.
62. Liu, J. Z., F. Tozzi, D. M. Waterworth, S. G. Pillai, P. Muglia, L. Middleton, W. Berrettini, et al. 2010. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 42: 436-440.
63. Llewellyn, C. H., M. Trzaskowski, C. H. M. van Jaarsveld, R. Plomin, and J. Wardle. 2014. Satiety mechanisms in genetic risk of obesity. JAMA Pediatr 168(4): 338-344. doi: 10.1001/jamapediatrics.2013.4944
64. Logue, J. M., N. E. Klepeis, A. B. Lobscheid, and B.C. Singer. 2014. Pollutant exposures from natural gas cooking burners: a simulation-based assessment for Southern California. Environ Health Perspect 122(1): 43-50.
65. Manolio, T. A. 2009. Cohort studies and the genetics of complex disease. Nat Genet 41(1): 5-6.
66. -. 2010. Genomewide association studies and assessment of the risk of disease. N Engl J Med 363: 166-176.
67. -. 2013. Bringing genome-wide association findings into clinical use. Nat Rev Genet 14(8): 549-558.
68. McClellan, J., and M.-C. King. 2010. Genetic heterogeneity in human disease. Cell 141(2): 210-217.
69. McIntosh, A. M., A. Gow, M. Luciano, G. Davies, D. C. Liewald, S. E. Harris, J. Corley, et al. 2014. Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age. Biological Psychiatry 73(10): 938-943. doi: 10.1016/j.biopsych.2013.01.011
70. Meier, M. H., A. Caspi, A. Reichenberg, R. S. E. Keefe, H. L. Fisher, H. Harrington, R. Houts, R. Poulton, and T. E. Moffitt. 2014. Neuropsychological decline in schizophrenia from the premorbid to the postonset period: evidence from a population-representative longitudinal study. Am J Psychiatry 171(1): 91-101.
71. Meigs, J. B., P. Shrader, L. M. Sullivan, J. B. McAteer, C. S. Fox, J. Dupuis, A. K. Manning, et al. 2008. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 359: 2208-2219.
72. Meyers, J. L., M. Cerdá, S. Galea, K. M. Keyes, A. E. Aiello, M. Uddin, D. E. Wildman, and K. C. Koenen. 2013. Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study. Transl Psychiatry 3(8): e290.
73. Milton, J. N., V. R. Gordeuk, J.G. Taylor, M. T. Gladwin, M. H. Steinberg, and P. Sebastiani. 2014. Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models. Circ Cardiovasc Genet 7(2): 110-115. doi: 10.1161/CIRCGENETICS.113.000387
74. Moffatt, M. F., M. Kabesch, L. Liang, A. L. Dixon, D. Strachan, S. Heath, M. Depner, et al. 2007. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448(7152): 470-473.
75. Moffitt, T. E., A. Caspi, and M. Rutter. 2005. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 62(5): 473-481.
76. Morrison, A. C., L. A Bare, L. E. Chambless, S. G. Ellis, M. Malloy, J. P. Kane, J. S. Pankow, J. J. Devlin, J. T. Willerson, and E. Boerwinkle. 2007. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 166(1): 28-35.
77. Nikolova, Y. S., R. E. Ferrell, S. B. Manuck, and A. R. Hariri. 2011. Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology 36(9: 1940-1947.
78. Novembre, J., T. Johnson, K. Bryc, Z. Kutalik, A. R. Boyko, A. Auton, A. Indap, et al. 2008. Genes mirror geography within Europe. Nature 456(7218): 98-101.
79. Odgers, C. L., A. Caspi, C. J. Bates, R. J. Sampson, and T. E. Moffitt. 2012. Systematic social observation of children's neighborhoods using Google street view: a reliable and cost-effective method. J Child Psychol Psychiatry 53(10): 1009-1017.
80. Pearson, T. A., and T. A. Manolio. 2008. How to interpret a genome-wide association study. JAMA 299: 1335-1344.
81. Plomin, R., J. C. De Fries, G. E. McClearn, and P. McGuffin. 2008. Behavioral genetics, 5th ed. New York: Worth.
82. Plomin, R., C. M. A. Haworth, and O. S. P. Davis. 2009. Common disorders are quantitative traits. Nat Rev Genet 10(12): 872-878.
83. Price, A. L., N. J. Patterson, R. M. Plenge, M. E. Weinblatt, N. A. Shadick, and D. Reich. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909.
84. Purcell, S. M., J. L. Moran, M. Fromer, D. Ruderfer, N. Solovieff, P. Roussos, C. O'Dushlaine, et al. 2014. A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506: 185-190.
85. Purcell, S. M., B. Neale, K. Todd-Brown, L. Thomas, M. A. R. Ferreira, D. Bender, J. Maller, et al. 2007. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
86. Purcell, S. M., N. R. Wray, J. L. Stone, P. M. Visscher, M. C. O'Donovan, P. F. Sullivan, and P. Sklar. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256): 748-752.
87. Qi, Q., A. Y. Chu, J. H. Kang, M. K. Jensen, G. C. Curhan, L. R. Pasquale, P. M. Ridker, et al. 2012. Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 367(15): 1387-1396.
88. Qi, Q., Y. Li, A. K. Chomistek, J. H. Kang, G. C. Curhan, L. R. Pasquale, W. C. Willett, E. B. Rimm, F. B. Hu, and L. Qi. 2012. Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. Circulation 126(15): 1821-1827.
89. Rietveld, C. A, S. E. Medland, J. Derringer, J. Yang, T. Esko, N. W. Martin, H.-J. Westra, et al. 2013. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science 340(6139): 1467-1471.
90. Ripatti, S., E. Tikkanen, M. Orho-Melander, A. S. Havulinna, K. Silander, A. Sharma, C. Guiducci, et al. 2010. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet 376(9750): 1393-1400.
91. Ripke, S., C. O'Dushlaine, K. Chambert, J. L. Moran, A. K. Kähler, S. Akterin, S. E. Bergen, et al. 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 45(10): 1150-1159.
92. Saccone, N. L., R. C. Culverhouse, T.-H. Schwantes-An, D. S. Cannon, X. Chen, S. Cichon, I. Giegling, et al. 2010. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet 6(8). doi: 10.1371/journal.pgen.1001053
93. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. 2011. Genomewide association study identifies five new schizophrenia loci. Nat Genet 43(10): 969-976.
94. Schwartz, S., and E. Susser. 2010. Genome-wide association studies: does only size matter? Am J Psychiatry 167(7): 741-744.
95. Seddon, J. M., R. Reynolds, J. Maller, J. A. Fagerness, M. J. Daly, and B. Rosner. 2009. Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci 50(5): 2044-2053.
96. Shalev, I., E. Lerer, S. Israel, F. Uzefovsky, I. Gritsenko, D. Mankuta, R. P. Ebstein, and M. Kaitz. 2009. BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions. Psychoneuroendocrinology 34(3): 382-388.
97. Smemo, S., J. J. Tena, K.-H. Kim, E. R. Gamazon, N.J. Sakabe, C. Gómez-Marín, I. Aneas, et al. 2014. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507: 371-375.
98. Spycher, B. D., J. Henderson, R. Granell, D. M. Evans, G. D. Smith, N. J. Timpson, and J. A. C. Sterne. 2012. Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort. J Allergy Clin Immunol 130(2): 503-509e7.
99. Stice, E., S. Yokum, K. Burger, L. Epstein, and A. Smolen. 2012. Multilocus genetic composite reflecting dopamine signaling capacity predicts reward circuitry responsivity. J Neurosci 32(29): 10,093-10,100.
100. Sullivan, P. F. 2010. The psychiatric GWAS consortium: big science comes to psychiatry. Neuron 68(2): 182-186.
101. Sullivan, P. F., M. J. Daly, and M. O'Donovan. 2012. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 13(8): 537-551.
102. Tol, H. H. M. V., C. M. Wu, H.-C. Guan, K. Ohara, J. R. Bunzow, O. Civelli, J. Kennedy, P. Seeman, H. B. Niznik, and V. Jovanovic. 1992. Multiple dopamine D4 receptor variants in the human population. Nature 358(6382): 149-152.
103. Uhl, G. R., D. Walther, R. Musci, C. Fisher, J. C. Anthony, C. L. Storr, F. M. Behm, W. W. Eaton, N. Ialongo, and J. E. Rose. 2014. Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. Mol Psychiatry 19(1): 50-54. doi: 10.1038/mp.2012.155
104. Van Scheltinga, A. F. T., S. C. Bakker, N. E. M. van Haren, E. M. Derks, J. E. Buizer-Voskamp, W. Cahn, S. Ripke, Psychiatric Genome-Wide Association Study (GWAS) Consortium, R. A. Ophoff, and R. S. Kahn. 2013. Schizophrenia genetic variants are not associated with intelligence. Psychol Med 43(12): 2563-2570. doi: 10.1017/S0033291713000196
105. Visscher, P. M., W. G. Hill, and N. R. Wray. 2008. Heritability in the genomics era-concepts and misconceptions. Nat Rev Genet 9: 255-266.
106. Vrieze, S. I., M. McGue, and W. G. Iacono. 2012. The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. Hum Genet 131(6: 791-801.
107. Wardle, J., S. Carnell, C. M. A. Haworth, I. S. Farooqi, S. O'Rahilly, and R. Plomin. 2008. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 93(9): 3640-3643.
108. Wray, N. R., M. E. Goddard, and P. M. Visscher. 2007. Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res 17(10): 1520-1528.
109. Wray, N. R., J. Yang, B. J. Hayes, A. L. Price, M. E. Goddard, and P. M. Visscher. 2013. Pitfalls of predicting complex traits from SNPs. Nat Rev Genet 14(7): 507-515.
110. Yu, W., M. Gwinn, M. Clyne, A. Yesupriya, and M. J. Khoury. 2008. A navigator for human genome epidemiology. Nat Genet 40: 124-125.
111. Zhao, J., C. Jiang, T. H. Lam, B. Liu, K. K. Cheng, L. Xu, S. L. A. Yeung, W. Zhang, G. M. Leung, and C. M. Schooling. 2014. Genetically predicted testosterone and cardiovascular risk factors in men: a Mendelian randomization analysis in the Guangzhou biobank cohort study. Int J Epidemiol 43(1): 140-148.
112. Zuk, O., E. Hechter, S. R. Sunyaev, and E. S. Lander. 2012. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci U S A 109(4): 1193-1198.