Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age

Biological Psychiatry

Volumn 73, Issue 10, 2013, Pages 938-943

  McIntosh, Andrew M ^a   Gow, Alan ^a   Luciano, Michelle ^a   Davies, Gail ^a   Liewald, David C ^a   Harris, Sarah E ^a   Corley, Janie ^a   Hall, Jeremy ^a   Starr, John M ^a   Porteous, David J ^a   Tenesa, Albert ^b   Visscher, Peter M ^c   Deary, Ian J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Aging; cognition; dementia; schizophrenia

Indexed keywords

AGE DISTRIBUTION; AGED; AGING; ARTICLE; CEREBROVASCULAR ACCIDENT; CHILD; COGNITION; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGING; CHILD; COGNITION DISORDERS; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEALTH SURVEYS; HUMANS; INTELLIGENCE; MALE; NEUROPSYCHOLOGICAL TESTS; RESIDENCE CHARACTERISTICS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84876936728     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.01.011     Document Type: Article

References (42)

1. P. McGuffin, A.E. Farmer, I.I. Gottesman, R.M. Murray, and A.M. Reveley Twin concordance for operationally defined schizophrenia. Confirmation of familiality and heritability Arch Gen Psychiatry 41 1984 541 545
2. T. Sharma, and P. Harvey Cognition in Schizophrenia: Impairments, Importance and Treatment Strategies 2000 Oxford University Press London
3. P. Jones, B. Rodgers, R. Murray, and M. Marmot Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort Lancet 334 1994 1393 1402
4. A.S. David, A. Malmberg, L. Brandt, P. Allebeck, and G. Lewis IQ and risk for schizophrenia: A population-based cohort study Psychol Med 27 1997 1311 1323
5. S. Zammit, P. Allebeck, A.S. David, C. Dalman, T. Hemmingsson, I. Lundberg, and G. Lewis A longitudinal study of premorbid IQ score and risk of developing schizophrenia, bipolar disorder, severe depression, and other nonaffective psychoses Arch Gen Psychiatry 61 2004 354 360
6. M. Byrne, A. Hodges, E. Grant, D.C. Owens, and E.C. Johnstone Neuropsychological assessment of young people at high genetic risk for developing schizophrenia compare with controls: Preliminary findings of the Edinburgh High Risk Study (EHRS) Psychol Med 29 1999 1161 1173
7. R. Cosway, M. Byrne, R. Clafferty, A. Hodges, E. Grant, and S.S. Abukmeil Neuropsychological change in young people at high risk for schizophrenia: Results from the first two neuropsychological assessments of the Edinburgh High Risk Study Psychol Med 30 2000 1111 1121
8. A.M. McIntosh, L.K. Harrison, K. Forrester, S.M. Lawrie, and E.C. Johnstone Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives Br J Psychiatry 186 2005 378 385
9. T. Toulopoulou, M. Picchioni, F. Rijsdijk, M. Hua-Hall, U. Ettinger, P. Sham, and R. Muuurray Substantial genetic overlap between neurocognition and schizophrenia: Genetic modeling in twin samples Arch Gen Psychiatry 64 2007 1348 1355
10. D.C. Glahn, L. Almasy, J. Blangero, G.M. Burk, J. Estrada, and J.M. Peralta Adjudicating neurocognitive endophenotypes for schizophrenia Am J Med Genet B Neuropsychiatr Genet 144 2007 242 249
11. I.J. Deary, J. Yang, G. Davies, S.E. Harris, A. Tenesa, and D. Liewald Genetic contributions to stability and change in intelligence from childhood to old age Nature 482 2012 212 215
12. G. Davies, A. Tenesa, A. Payton, J. Yang, S.E. Harris, and D. Liewald Genome-wide association studies establish that human intelligence is highly heritable and polygenic Mol Psychiatry 16 2011 996 1005
13. I.J. Deary, W. Johnson, and L.M. Houlihan Genetic foundations of human intelligence Hum Genet 126 2009 215 232
14. I.J. Deary, A.J. Gow, M.D. Taylor, J. Corley, C. Brett, and V. Wilson The Lothian Birth Cohort 1936: A study to examine influences on cognitive ageing from age 11 to age 70 and beyond BMC Geriatr 7 2007 28
15. International Schizophrenia Consortium S.M. Purcell, N.R. Wray, J.L. Stone, P.M. Visscher, and M.C. O'Donovan Common polygenic variation contributes to risk of schizophrenia and bipolar disorder Nature 460 2009 748 752
16. I.J. Deary, A.J. Gow, A. Pattie, and J.M. Starr Cohort profile: The Lothian Birth Cohorts of 1921 and 1936 Int J Epidemiol 41 2012 1576 1584
17. A.J. Gow, J. Corley, J.M. Starr, and I.J. Deary Reverse causation in activity-cognitive ability associations: The Lothian Birth Cohort 1936 Psychol Aging 27 2012 250 255
18. D. Wechsler WAIS-IIIUK Administration and Scoring Manual 1998 Psychological Corporation London
19. D. Wechsler WMS-IIIUK Administration and Scoring Manual 1998 Psychological Corporation London
20. J. Corley, X. Jia, J.A. Kyle, A.J. Gow, C.E. Brett, and J.M. Starr Caffeine consumption and cognitive function at age 70: The Lothian Birth Cohort 1936 study Psychosom Med 72 2010 206 214
21. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium Genome-wide association study identifies five new schizophrenia loci Nat Genet 43 2011 969 976
22. G.J. Biessels, I.J. Deary, and C.M. Ryan Cognition and diabetes: A lifespan perspective Lancet Neurol 7 2008 184 190
23. L. Kilander, H. Nyman, M. Boberg, L. Hansson, and H. Lithell Hypertension is related to cognitive impairment: A 20-year follow-up of 999 men Hypertension 31 1998 780 786
24. V.C. Mok, A. Wong, W.W. Lam, Y.H. Fan, W.K. Tang, and T. Kwok Cognitive impairment and functional outcome after stroke associated with small vessel disease J Neurol Neurosurg Psychiatry 75 2004 560 566
25. A.J. Gow, W. Johnson, A. Pattie, C.E. Brett, B. Roberts, J.M. Starr, and I.J. Deary Stability and change in intelligence from age 11 to ages 70, 79, and 87: The Lothian Birth Cohorts of 1921 and 1936 Psychol Aging 26 2011 232 240
26. J.C. Raven, J.H. Court, and J. Raven Manual for Raven's Progressive Matrices and Vocabulary Scales 1977 H. K. Lewis London
27. M.D. Lezak Neuropsychological Assessment 1995 Oxford University Press New York
28. D. Wechsler Wechsler Memory Scale-Revised 1987 Psychological Corporation San Antonio, TX
29. E. Aylward, E. Walker, and B. Bettes Intelligence in schizophrenia: Meta-analysis of the research Schizophr Bull 10 1984 430 459
30. J.T. Walters, A. Corvin, M.J. Owen, H. Williams, M. Dragovic, and E.M. Quinn Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia Arch Gen Psychiatry 67 2010 692 700
31. J. Hall, H.C. Whalley, D.E. Job, B.J. Baig, A.M. McIntosh, and K.L. Evans A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms Nat Neurosci 9 2006 1477 1478
32. D.J. Porteous, P. Thomson, N.J. Brandon, and J.K. Millar The genetics and biology of DISC1 - an emerging role in psychosis and cognition Biol Psychiatry 60 2006 123 131
33. S.H. Lee, T.R. DeCandia, S. Ripke, J. Yang, Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), and International Schizophrenia Consortium (ISC) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs Nat Genet 44 2012 247 250
34. D. Posthuma, E.J. Mulder, D.I. Boomsma, and E.J. de Geus Genetic analysis of IQ, processing speed and stimulus-response incongruency effects Biol Psychol 61 2002 157 182
35. T. Fowler, S. Zammit, M.J. Owen, and F. Rasmussen A population-based study of shared genetic variation between premorbid IQ and psychosis among male twin pairs and sibling pairs from Sweden Arch Gen Psychiatry 69 2012 460 466
36. D.C. Glahn, J.E. Curran, A.M. Winkler, M.A. Carless, J.W. Kent Jr, and J.C. Charlesworth High dimensional endophenotype ranking in the search for major depression risk genes Biol Psychiatry 71 2012 6 14
37. Scottish Council for Research in Education The Intelligence of Scottish Children: A National Survey of an Age-Group 1933 University of London Press London
38. I.J. Deary, W. Johnson, and J.M. Starr Are processing speed tasks biomarkers of cognitive aging? Psychol Aging 25 2010 219 228
39. I.J. Deary, M.C. Whiteman, J.M. Starr, L.J. Whalley, and H.C. Fox The impact of childhood intelligence on later life: Following up the Scottish mental surveys of 1932 and 1947 J Pers Soc Psychol 86 2004 130 147
40. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate - a practical and powerful approach to multiple testing J R Stat Soc Series B Stat Methodol 57 1995 289 300
41. J. Beddington, C.L. Cooper, J. Field, U. Goswami, F.A. Huppert, and R. Jenkins The mental wealth of nations Nature 455 2008 1057 1060
42. S.E. Harris, and I.J. Deary The genetics of cognitive ability and cognitive ageing in healthy older people Trends Cogn Sci 15 2011 388 394