Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 20, 2014, Pages 5547-5554

  Polic, Vanja ^a   Auclair, Karine ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Anchoring molecule; Biocatalysis; Chemical auxiliary; Decoy molecule; Directing group; Fatty acid; Molecularly imprinted polymer; Perfluorinated carboxylic acid

Indexed keywords

CARBOXYLIC ACID; CYTOCHROME P450; CYTOCHROME P450 3A4; FATTY ACID; HEPTANOIC ACID DERIVATIVE; HEXANOIC ACID; LISOFYLLINE; NICOTINIC ACID; PERFLUORO COMPOUND; PERFLUORO FATTY ACID; SHORT CHAIN FATTY ACID; TERTIARY AMINE; THEOBROMINE; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYSIS; BIOCATALYST; CHEMISTRY; COVALENT BOND; ENZYME ENGINEERING; ENZYME SPECIFICITY; HYDROXYLATION; OXIDATION; REGIOSELECTIVITY; STEREOCHEMISTRY; SULFOXIDATION; DRUG EFFECTS; HUMAN; METABOLISM; STEREOISOMERISM;

BIOCATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84908461234     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.06.034     Document Type: Article

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