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Volumn 511, Issue 1-2, 2011, Pages 69-79

The kinetic mechanism for cytochrome P450 metabolism of Type II binding compounds: Evidence supporting direct reduction

(7) Pearson, Joshua b Dahal, Upendra P a Rock, Daniel b Peng, Chi Chi a Schenk, James O a Joswig Jones, Carolyn a Jones, Jeffrey P a

a WASHINGTON STATE UNIVERSITY (United States)

b AMGEN INC (United States)

Author keywords

Drug metabolism; Kinetics; P450; Type II binding

Indexed keywords

CYTOCHROME P450; IRON;

ARTICLE; CATALYSIS; KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN METABOLISM; PROTEIN STABILITY; SURFACE PLASMON RESONANCE; TYPE II BINDING;

CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; DRUG STABILITY; HEME; HUMANS; IRON; KINETICS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NITROGEN; OXIDATION-REDUCTION; QUINOLINES; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; TANDEM MASS SPECTROMETRY;

EID: 79958841704 PISSN: 00039861 EISSN: 10960384 Source Type: Journal
DOI: 10.1016/j.abb.2011.04.008 Document Type: Article

Times cited : (25)

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