Comparative study of the affinity and metabolism of type i and type II binding quinoline carboxamide analogues by cytochrome P450 3A4

Journal of Medicinal Chemistry

Volumn 55, Issue 1, 2012, Pages 280-290

  Dahal, Upendra P ^a   Joswig Jones, Carolyn ^a   Jones, Jeffrey P ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CYTOCHROME P450 3A4; N (4 HYDROXYPHENYL) 2 PHENYLQUINOLINE 4 CARBOXAMIDE; N [4 (HYDROXYMETHYL)PHENYL] 2 PHENYLQUINOLINE 4 CARBOXAMIDE; N [4 (METHYLAMINO)PHENYL] 2 PHENYLQUINOLINE 4 CARBOXAMIDE; QUINOLINE CARBOXAMIDE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DEALKYLATION; DEMETHYLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROXYLATION; OXIDATION; PROTEIN METABOLISM;

AMIDES; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP3A; DEALKYLATION; HYDROXYLATION; PROTEIN BINDING; PYRAZINES; PYRIDINES; PYRIMIDINES; QUINOLINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84863408056     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201207h     Document Type: Article

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