The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1

Chemico-Biological Interactions

Volumn 193, Issue 1, 2011, Pages 50-56

  Jones, Jeffrey P ^a   Joswig Jones, Carolyn A ^a   Hebner, Michelle ^a,b   Chu, Yuzhuo ^a   Koop, Dennis R ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

2E1; CYP; Nitrogen iron coordination; P450; QSAR; Type II binding

Indexed keywords

1 METHYLIMIDAZOLE; 3,5 DIMETHYLPYRIDINE; 4 NITROPHENOL; 6 HYDROQUINOLINE; CHLORZOXAZONE; CYTOCHROME P450 2E1; HEME; IMIDAZOLE; IRON; ISOQUINOLINE; NITROGEN; OCTANOL; PYRAZOLE; PYRIDINE DERIVATIVE; QUINOLINOL DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SUBSTRATE; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PROTEIN BINDING; PROTEIN INTERACTION; SOLVENT EFFECT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PROPERTY;

CHLORZOXAZONE; CYTOCHROME P-450 CYP2E1; HEME; IRON; KINETICS; NITROGEN; NITROPHENOLS; PROTEIN BINDING; QUANTUM THEORY; SOLVENTS; SUBSTRATE SPECIFICITY;

EID: 80955177088     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.05.001     Document Type: Article

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