The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4

Archives of Biochemistry and Biophysics

Volumn 497, Issue 1-2, 2010, Pages 68-81

  Peng, Chi Chi ^a   Pearson, Josh T ^b   Rock, Dan A ^b   Joswig Jones, Carolyn A ^a   Jones, Jeffrey P ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b AMGEN INC   (United States)

Author keywords

3A4; Metabolic stability; P450; Type II binding

Indexed keywords

AMIDE; CYTOCHROME P450 3A4; HEME; NITROGEN; OXYGEN;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; ENZYME BINDING; ENZYME SUBSTRATE; OXYGEN AFFINITY; PRIORITY JOURNAL;

BIOCHEMICAL PROCESSES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; HEME; HUMANS; KINETICS; MODELS, CHEMICAL; PHYSICAL PROCESSES; PROTEIN BINDING;

EID: 77952547981     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2010.03.011     Document Type: Article

References (23)

1. Ortiz de Montellano P.R. Cytochrome P450: Structure, Mechanism, and Biochemistry 1995, Plenum, New York. D.M. de Ortiz (Ed.).
2. Chiba M., Tang C., Neway W.E., Williams T.M., Desolms S.J., Dinsmore C.J., Wai J.S., Lin J.H. Biochem. Pharmacol. 2001, 62:773-776.
3. Chiba M., Jin L., Neway W., Vacca J.P., Tata J.R., Chapman K., Lin J.H. Drug Metab. Dispos. 2001, 29:1-3.
4. Peng C.C., Rushmore T., Crouch G.J., Jones J.P. Bioorg. Med. Chem. 2008, 16:4064-4074.
5. Peng C.C., Cape J.L., Rushmore T., Crouch G.J., Jones J.P. J. Med. Chem. 2008, 51:8000-8011.
6. Hudelson M.G., Ketkar N.S., Holder L.B., Carlson T.J., Peng C.C., Waldher B.J., Jones J.P. J. Med. Chem. 2008, 51:648-654.
7. Dickmann L.J., Locuson C.W., Jones J.P., Rettie A.E. Mol. Pharmacol. 2004, 65:842-850.
8. Locuson C.W., Hutzler J.M., Tracy T.S. Drug Metab. Dispos. 2007, 35:614-622.
9. Kumaki K., Sato M., Kon H., Nebert D.W. J. Biol. Chem. 1978, 253:1048-1058.
10. Henderson P.J. A statistical treatment of dose-response curves. Biochem. J. 1973, 135:101-107.
11. Staroverov V.N., Scuseria G.E., Tao J.M., Perdew J.P. J. Chem. Phys. 2003, 119:12129-12137.
12. Groenhof A.R., Swart M., Ehlers A.W., Lammertsma K. J. Phys. Chem. 2005, 109:3411-3417.
13. Peterson K.A., Figgen D., Dolg M., Stoll H. J. Chem. Phys. 2007, 126:124101.
14. Sharma P.K., De Visser S.P., Shaik S. J. Am. Chem. Soc. 2003, 125:8698-8699.
15. Shaik S., Kumar D., de Visser S.P., Altun A., Thiel W. Chem. Rev. 2005, 105:2279-2328.
16. Cho K.B., Moreau Y., Kumar D., Rock D.A., Jones J.P., Shaik S. Chem. Eur. J. 2007, 13:4103-4115.
17. Johnson E.F., Schwab G.E., Vickery L.E. J. Biol. Chem. 1988, 263:17672-17677.
18. Testa B., Jenner P. Drug Metab. Rev. 1981, 12:1-117.
19. Pearson J.T., Hill J.J., Swank J., Isoherranen N., Kunze K.L., Atkins W.M. Biochemistry 2006, 45:6341-6353.
20. Iyer K.R., Jones J.P., Darbyshire J.F., Trager W.F. Biochemistry 1997, 36:7136-7143.
21. Higgins L., Bennett G.A., Shimoji M., Jones J.P. Biochemistry 1998, 37:7039-7046.
22. Audergon C., Iyer K.R., Jones J.P., Darbyshire J.F., Trager W.F. J. Am. Chem. Soc. 1999, 121:41-47.
23. Das A., Sligar S.G. Biochemistry 2009, 48:12104-12112.