Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 29859-29873

  Nemeria, Natalia S ^a   Ambrus, Attila ^b   Patel, Hetalben ^a   Gerfen, Gary ^c   Adam Vizi, Vera ^b   Tretter, Laszlo ^b   Zhou, Jieyu ^a   Wang, Junjie ^a   Jordan, Frank ^a  

^a RUTGERS UNIVERSITY   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYMES; FREE RADICALS; IONS; MAGNETIC MOMENTS; OXYGEN;

2-OXOGLUTARATE DEHYDROGENASE COMPLEXES; ENAMINE INTERMEDIATES; INDIVIDUAL COMPONENTS; MULTIENZYME COMPLEXES; RATE-LIMITING ENZYMES; REACTIVE OXYGEN SPECIES; SPECTROSCOPIC EVIDENCE; SUPEROXIDE ANION RADICALS;

REACTION INTERMEDIATES;

(C2 ALPHA HYDROXY)CARBOXYPROPYLIDENE THIAMINE DIPHOSPHATE; 2 OXOGLUTARATE DEHYDROGENASE COMPLEX E1; CITRIC ACID; ENAMINE; HYDROGEN PEROXIDE; OXOGLUTARATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUPEROXIDE; THIAMINE; UNCLASSIFIED DRUG; 2 OXOGLUTARIC ACID; ALPHA-KETOGLUTARIC ACID; AMINE; COCARBOXYLASE; FREE RADICAL; PHOSPHINIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; EMBRYO; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION; CIRCULAR DICHROISM; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION; SPECTROSCOPY;

AMINES; CIRCULAR DICHROISM; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HUMANS; KETOGLUTARATE DEHYDROGENASE COMPLEX; KETOGLUTARIC ACIDS; KINETICS; ORGANOPHOSPHONATES; OXIDATION-REDUCTION; PHOSPHINIC ACIDS; REACTIVE OXYGEN SPECIES; SPECTRUM ANALYSIS; THIAMINE; THIAMINE PYROPHOSPHATE;

EID: 84908430571     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.591073     Document Type: Article

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