Crystal structure of human dihydrolipoamide dehydrogenase: NAD +/NADH binding and the structural basis of disease-causing mutations

Journal of Molecular Biology

Volumn 350, Issue 3, 2005, Pages 543-552

  Brautigam, Chad A ^a   Chuang, Jacinta L ^a   Tomchick, Diana R ^a   Machius, Mischa ^a   Chuang, David T ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Dihydrolipoamide dehydrogenase; E3; Lipoamide dehydrogenase; X ray crystallography

Indexed keywords

DIHYDROLIPOAMIDE DEHYDROGENASE; FLAVINE ADENINE NUCLEOTIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; BAY REGION BINDING SITE; BINDING AFFINITY; CATALYSIS; CONFORMATION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEFICIENCY; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; MUTAGENESIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN FOLDING; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; YEAST;

CELLULAR ORGANISMS;

EID: 20444475852     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.05.014     Document Type: Article

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