The 1′,4′-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 1, 2007, Pages 78-82

  Nemeria, Natalia ^a   Chakraborty, Sumit ^a   Baykal, Ahmet ^a   Korotchkina, Lioubov G ^b   Patel, Mulchand S ^b   Jordan, Frank ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

1 ,4 iminothiamin diphospate; 2 oxoacid decarboxylases; Active site asymmetry

Indexed keywords

CARBENE; COCARBOXYLASE; PYRIMIDINE DERIVATIVE; PYRUVATE DECARBOXYLASE; PYRUVATE DEHYDROGENASE; PYRUVATE OXIDASE; PYRUVIC ACID; THIAZOLE DERIVATIVE; PROTEIN SUBUNIT; PYRUVATE DEHYDROGENASE COMPLEX;

ARTICLE; CATALYSIS; CIRCULAR DICHROISM; ENZYME ACTIVE SITE; ENZYME SUBUNIT; ESCHERICHIA COLI; LACTOBACILLUS PLANTARUM; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; HUMAN;

ESCHERICHIA COLI;

BINDING SITES; CATALYSIS; CIRCULAR DICHROISM; HUMANS; PROTEIN SUBUNITS; PYRUVATE DECARBOXYLASE; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE OXIDASE; THIAMINE PYROPHOSPHATE;

EID: 33846041174     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609973104     Document Type: Article

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