Potent heterocyclic ligands for human complement C3a receptor

Journal of Medicinal Chemistry

Volumn 57, Issue 20, 2014, Pages 8459-8470

  Reid, Robert C ^a   Yau, Mei Kwan ^a   Singh, Ranee ^a,b   Hamidon, Johan K ^a   Lim, Junxian ^a   Stoermer, Martin J ^a   Fairlie, David P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b KHON KAEN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

(2 BENZHYDRYL 1,4 DIMETHYL 1H IMIDAZOLE 5 CARBONYL) L ARGININE; (2 BENZHYDRYL 1,5 DIMETHYL 1H IMIDAZOLE 4 CARBONYL) L ARGININE; (2 BENZHYDRYL 1H IMIDAZOLE 5 CARBONYL) L ARGININE; (2 BENZHYDRYL 4 METHYL 1H IMIDAZOLE 5 CARBONYL) L ARGININE; (2 BENZHYDRYL 4 METHYLOXAZOLE 5 CARBONYL) L ARGININE; (2 BENZHYDRYL 4 PHENYL 1H IMIDAZOLE 5 CARBONYL) L ARGININE; (2 BENZHYDRYL 4 PHENYLOXAZOLE 5 CARBONYL) L ARGININE; (2 BENZHYDRYL 5 METHYLOXAZOLE 4 CARBONYL) L ARGININE; (2 BENZHYDRYLOXAZOLE 4 CARBONYL) L ARGININE; (2,2 DIPHENYLETHYL)GLYCYL L ARGININE; (3 BENZHYDRYL 1,2,4 OXADIAZOLE 5 CARBONYL) L ARGININE; (5 BENZHYDRYL 1,2,4 OXADIAZOLE 3 CARBONYL) L ARGININE; (5 BENZHYDRYL 1,3,4 OXADIAZOLE 2 CARBONYL) L ARGININE; (5 BENZHYDRYLFURAN 2 CARBONYL) L ARGININE; (5,5 DIPHENYLPENTANOYL) L ARGININE; ANTIINFLAMMATORY AGENT; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR LIGAND; HETEROCYCLIC COMPOUND; IMMUNOSTIMULATING AGENT; INTERLEUKIN 1BETA; IODINE 125; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; N2 [(2,2 DIPHENYLETHOXY)ACETYL] L ARGINIE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; [2 (2,2 DIPHENYLETHOXY)ACETYL] L ARGININE; [2 [(2,2 DIPHENYLETHYL)THIO]ACETYL] L ARGININE; ARGININE; BENZHYDRYL DERIVATIVE; CALCIUM; COMPLEMENT C3A RECEPTOR; COMPLEMENT RECEPTOR; IMMUNOLOGICAL ADJUVANT; LIGAND; SB 290157;

ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION ASSAY; DRUG SYNTHESIS; EC50; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; MACROPHAGE; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING ASSAY; STRUCTURE ACTIVITY RELATION; AGONISTS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; SYNTHESIS;

ADJUVANTS, IMMUNOLOGIC; ARGININE; BENZHYDRYL COMPOUNDS; CALCIUM; CELLS, CULTURED; CHEMISTRY TECHNIQUES, SYNTHETIC; GENE EXPRESSION REGULATION; HETEROCYCLIC COMPOUNDS; HUMANS; HYDROGEN BONDING; LIGANDS; MACROPHAGES; RECEPTORS, COMPLEMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908374192     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500956p     Document Type: Article

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