Cutting edge: Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5406-5409

  Kildsgaard, J ^a   Hollmann, T J ^a   Matthews, K W ^a   Bian, K ^a   Murad, F ^a   Wetsel, R A ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A; CYTOKINE;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; GENE DISRUPTION; GENE DOSAGE; GENE TARGETING; INFLAMMATION; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0034670027     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5406     Document Type: Article

References (18)

1. C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation
2. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1
3. C3a-induced contraction of guinea pig lung parenchyma: Role of cyclooxygenase metabolites
4. C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway
5. Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells
6. A new biologic role for C3a and C3a desArg: Regulation of TNF-α and IL-1-β synthesis
7. Regulation of B cell functions by C3a and C3a(desArg): Suppression of TNF-α, IL-6, and the polyclonal immune response
8. Endotoxin-induced shock in the rat. A role for C5a
9. Anaphylatoxin formation in sepsis
10. Terminal complement complexes and anaphylatoxins in septic and ischemic patients
11. Anaphylatoxin generation in multisystem organ failure
12. Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis
13. Biologically active products of complement and acute lung injury in patients with the sepsis syndrome
14. Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene
15. Analysis of mice containing a targeted deletion of β-globin locus control region 5' hypersensitive site 3
16. Preparation of mouse cell suspensions
17. Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat
18. Mice deficient in IL-1 β-converting enzyme are defective in production of mature IL-1 β and resistant to endotoxic shock