Heterocycles in drugs and drug discovery

Chemistry of Heterocyclic Compounds

Volumn 48, Issue 1, 2012, Pages 7-10

  Gomtsyan, A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

bioisosteres; ClogP; drug discovery; heterocycles; hydrogen bonding; lipophilicity; polarity; PSA; TPSA

Indexed keywords

EID: 84861228775     PISSN: 00093122     EISSN: 15738353     Source Type: Journal    
DOI: 10.1007/s10593-012-0960-z     Document Type: Article

References (10)

1. D. J. Mack, M. L. Weinrich, E. Vitaku, J. T. Njardarson, http://cbc.arizona.edu/njardarson/group/top-pharmaceuticals-poster.
2. NA Meanwell 2011 J. Med. Chem. 54 2529 10.1021/jm1013693 1:CAS:528:DC%2BC3MXjsVCnu7o%3D
3. G Le N Vandegraaff DI Rhodes ED Jones JAV Coates N Thienthong LJ Winfield L Lu X Li C Yu X Feng JJ Deadman 2010 Bioorg. Med. Chem. Lett. 20 5909 10.1016/j.bmcl.2010.07.081 1:CAS:528:DC%2BC3cXhtFGnt73J
4. C Laurence KA Brameld J Graton J-Y Le Questel E Renault 2009 J. Med. Chem. 52 4073 10.1021/jm801331y 1:CAS:528:DC%2BD1MXnsFKns7w%3D
5. MJ Waring 2010 Expert Opin. Drug Discovery 5 235 10.1517/ 17460441003605098 1:CAS:528:DC%2BC3cXisFOjtbc%3D
6. CA Lipinski F Lombardo BW Dominy PJ Feeney 1997 Adv. Drug Delivery Rev. 23 3 10.1016/S0169-409X(96)00423-1 1:CAS:528:DyaK2sXktlKlsQ%3D%3D (Pubitemid 27046991)
7. TT Wager X Hou PR Verhoest A Villalobos 2010 ACS Chem. Neurosci. 1 435 10.1021/cn100008c 1:CAS:528:DC%2BC3cXjvVejtr8%3D
8. PD Leeson JR Empfield 2010 Annu. Rep. Med. Chem. 45 393 10.1016/S0065-7743(10)45024-1 1:CAS:528:DC%2BC3cXhsFSgu73N
9. AS Kalgutkar J Driscoll SX Zhao GS Walker RM Shepard JR Soglia J Atherton L Yu AE Mutlib MJ Munchhof LA Reiter SC Jones JL Doty KA Trevena CL Shaffer SL Ripp 2007 Chem. Res. Toxicol. 20 1954 10.1021/tx700270r 1:CAS:528: DC%2BD2sXhtFKhtbfM
10. C Liljebris SD Larsen D Ogg BL Palazuk JE Bleasdale 2002 J. Med. Chem. 45 1785 10.1021/jm011100y 1:CAS:528:DC%2BD38XitlOktLc%3D (Pubitemid 34415374)