De novo peptide design with C3a receptor agonist and antagonist activities: Theoretical predictions and experimental validation

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4159-4168

  Bellows Peterson, Meghan L ^a   Fung, Ho Ki ^a   Floudas, Christodoulos A ^a   Kieslich, Chris A ^b   Zhang, Li ^b   Morikis, Dimitrios ^b   Wareham, Kathryn J ^c   Monk, Peter N ^c   Hawksworth, Owen A ^d   Woodruff, Trent M ^d  

^a Princeton University   (United States)

^b University of California Riverside   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR AGONIST; COMPLEMENT COMPONENT C3A RECEPTOR ANTAGONIST; PARTIAL AGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; ELECTRIC POTENTIAL; IC 50; MAST CELL DEGRANULATION; MAST CELL LEUKEMIA; NONHUMAN; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; BASOPHILS; COMPLEMENT C3A; COMPUTATIONAL BIOLOGY; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; RATS; RECEPTORS, COMPLEMENT; STATIC ELECTRICITY; U937 CELLS;

EID: 84861052232     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201609k     Document Type: Article

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