The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation

Diabetes

Volumn 58, Issue 9, 2009, Pages 2006-2017

  Mamane, Yaël ^a   Chan, Chi Chung ^a   Lavallee, Genevieve ^a   Morin, Nicolas ^a   Xu, Li Jing ^a   Huang, JingQi ^a   Gordon, Robert ^a   Thomas, Winston ^b   Lamb, John ^c   Schadt, Eric E ^c   Kennedy, Brian P ^a   Mancini, Joseph A ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b Deltagen   (United States)

^c ROSETTA INPHARMATICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FATTY LIVER; GENE DELETION; GENE EXPRESSION; HORMONE ACTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MACROPHAGE ACTIVATION; MACROPHAGE MIGRATION; MALE; MEDIATOR RELEASE; MOUSE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PRIORITY JOURNAL; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOSE TISSUE; ANIMALS; CELL MOVEMENT; DIETARY FATS; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OBESITY; PHENOTYPE; RECEPTORS, COMPLEMENT;

EID: 70349126762     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0323     Document Type: Article

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