Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification

EMBO Journal

Volumn 33, Issue 19, 2014, Pages 2157-2170

  Xu, Cheng Ran ^a,b   Li, Lin Chen ^b   Donahue, Greg ^a   Ying, Lei ^c   Zhang, Yu Wei ^b   Gadue, Paul ^c   Zaret, Kenneth S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Tsinghua University   (China)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Development Differentiation; Embryogenesis; Endocrine; Ezh2; H3K27me3; Pancreas Subject Categories Chromatin, Epigenetics, Genomics Functional Genomics; Stem Cells

Indexed keywords

HISTONE DEMETHYLASE; HISTONE H3; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR EZH2; CRE RECOMBINASE; EZH2 PROTEIN, MOUSE; HISTONE; INTEGRASE; KDM6B PROTEIN, MOUSE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENDOCRINE CELL; ENDODERM; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER DEVELOPMENT; MORPHOGENESIS; NONHUMAN; PANCREAS CELL; PANCREAS ISLET; PROMOTER REGION; PROTEIN DOMAIN; REGULATOR GENE; STEM CELL; TRANSCRIPTION REGULATION; ANIMAL; CELL CULTURE; CELL LINEAGE; CHROMATIN IMMUNOPRECIPITATION; CYTOLOGY; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE; ORGANOGENESIS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; EMBRYONIC STEM CELLS; ENDOCRINE CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONES; HUMANS; IMMUNOENZYME TECHNIQUES; INTEGRASES; ISLETS OF LANGERHANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MICE; MICE, KNOCKOUT; ORGANOGENESIS; POLYCOMB REPRESSIVE COMPLEX 2; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS;

EID: 84908115420     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201488671     Document Type: Article

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