메뉴 건너뛰기




Volumn 57, Issue 19, 2014, Pages 8010-8025

Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ETHER DERIVATIVE; FLUOROURACIL; GEFITINIB; HYDROXYTAMOXIFEN; NAPHTHALENE DERIVATIVE; OXIME DERIVATIVE; PERTUSSIS TOXIN; PROTEIN TYROSINE KINASE; RALOXIFENE; SALINOMYCIN; THIOARYL NAPHTHYLMETHANONE OXIME ETHER DERIVATIVE; UNCLASSIFIED DRUG; [4 (METHYLTHIO)PHENYL](NAPHTHALEN 1 YL)METHANONE O 2 (DIETHYLAMINO)ETHYL OXIME; 4-(METHYLTHIO)PHENYL)(NAPHTHALEN-1-YL)METHANONE O-2-(DIETHYLAMINO)ETHYL OXIME; BENZHYDRYL DERIVATIVE; OXIME;

EID: 84907929436     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500873e     Document Type: Article
Times cited : (43)

References (80)
  • 1
    • 84872243145 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: Views of selectivity, sensitivity, and clinical performance
    • Levitzki, A. Tyrosine kinase inhibitors: views of selectivity, sensitivity, and clinical performance Annu. Rev. Pharmacol. Toxicol. 2013, 53, 161-185
    • (2013) Annu. Rev. Pharmacol. Toxicol. , vol.53 , pp. 161-185
    • Levitzki, A.1
  • 2
    • 84055207507 scopus 로고    scopus 로고
    • Lapatinib induces autophagy, apoptosis and megakaryocytic differentiation in chronic myelogenous leukemia K562 cells
    • Huang, H. L.; Chen, Y. C.; Huang, Y. C.; Yang, K. C.; Pan, H.; Shih, S. P.; Chen, Y. J. Lapatinib induces autophagy, apoptosis and megakaryocytic differentiation in chronic myelogenous leukemia K562 cells PLoS One 2011, 6, e29014
    • (2011) PLoS One , vol.6 , pp. 29014
    • Huang, H.L.1    Chen, Y.C.2    Huang, Y.C.3    Yang, K.C.4    Pan, H.5    Shih, S.P.6    Chen, Y.J.7
  • 4
    • 84884869442 scopus 로고    scopus 로고
    • EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells
    • Lainey, E.; Wolfromm, A.; Sukkurwala, A. Q.; Micol, J. B.; Fenaux, P.; Galluzzi, L.; Kepp, O.; Kroemer, G. EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells Cell Cycle 2013, 12, 2978-2991
    • (2013) Cell Cycle , vol.12 , pp. 2978-2991
    • Lainey, E.1    Wolfromm, A.2    Sukkurwala, A.Q.3    Micol, J.B.4    Fenaux, P.5    Galluzzi, L.6    Kepp, O.7    Kroemer, G.8
  • 8
    • 36348967305 scopus 로고    scopus 로고
    • Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
    • Shi, Z.; Peng, X. X.; Kim, I. W.; Shukla, S.; Si, Q. S.; Robey, R. W.; Bates, S. E.; Shen, T.; Ashby, C. R., Jr.; Fu, L. W.; Ambudkar, S. V.; Chen, Z. S. Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance Cancer Res. 2007, 67, 11012-11020
    • (2007) Cancer Res. , vol.67 , pp. 11012-11020
    • Shi, Z.1    Peng, X.X.2    Kim, I.W.3    Shukla, S.4    Si, Q.S.5    Robey, R.W.6    Bates, S.E.7    Shen, T.8    Ashby, C.R.9    Fu, L.W.10    Ambudkar, S.V.11    Chen, Z.S.12
  • 10
    • 0642303647 scopus 로고    scopus 로고
    • Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage
    • Jacquel, A.; Herrant, M.; Legros, L.; Belhacene, N.; Luciano, F.; Pages, G.; Hofman, P.; Auberger, P. Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage FASEB J. 2003, 17, 2160-2162
    • (2003) FASEB J. , vol.17 , pp. 2160-2162
    • Jacquel, A.1    Herrant, M.2    Legros, L.3    Belhacene, N.4    Luciano, F.5    Pages, G.6    Hofman, P.7    Auberger, P.8
  • 11
    • 50449087729 scopus 로고    scopus 로고
    • Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK
    • Ling, Y. H.; Lin, R.; Perez-Soler, R. Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK Mol. Pharmacol. 2008, 74, 793-806
    • (2008) Mol. Pharmacol. , vol.74 , pp. 793-806
    • Ling, Y.H.1    Lin, R.2    Perez-Soler, R.3
  • 12
    • 0141499968 scopus 로고    scopus 로고
    • Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor
    • Newcomb, E. W.; Tamasdan, C.; Entzminger, Y.; Alonso, J.; Friedlander, D.; Crisan, D.; Miller, D. C.; Zagzag, D. Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor Cell Cycle 2003, 2, 243-250
    • (2003) Cell Cycle , vol.2 , pp. 243-250
    • Newcomb, E.W.1    Tamasdan, C.2    Entzminger, Y.3    Alonso, J.4    Friedlander, D.5    Crisan, D.6    Miller, D.C.7    Zagzag, D.8
  • 13
    • 77956520347 scopus 로고    scopus 로고
    • Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines
    • Premkumar, D. R.; Jane, E. P.; Pollack, I. F. Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines Int. J. Oncol. 2010, 37, 633-643
    • (2010) Int. J. Oncol. , vol.37 , pp. 633-643
    • Premkumar, D.R.1    Jane, E.P.2    Pollack, I.F.3
  • 14
    • 84877908566 scopus 로고    scopus 로고
    • Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases
    • Shaker, M. E.; Ghani, A.; Shiha, G. E.; Ibrahim, T. M.; Mehal, W. Z. Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases Biochim. Biophys. Acta 2013, 1833, 1992-2003
    • (2013) Biochim. Biophys. Acta , vol.1833 , pp. 1992-2003
    • Shaker, M.E.1    Ghani, A.2    Shiha, G.E.3    Ibrahim, T.M.4    Mehal, W.Z.5
  • 15
    • 14044257773 scopus 로고    scopus 로고
    • Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells
    • Wesierska-Gadek, J.; Gueorguieva, M.; Horky, M. Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells Mol. Cancer Ther. 2005, 4, 113-124
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 113-124
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Horky, M.3
  • 16
    • 79551716681 scopus 로고    scopus 로고
    • Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae
    • Wu, J.; Min, R.; Wu, M.; Chen, W. Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae Mol. Med. Rep. 2011, 4, 357-362
    • (2011) Mol. Med. Rep. , vol.4 , pp. 357-362
    • Wu, J.1    Min, R.2    Wu, M.3    Chen, W.4
  • 18
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella, R.; Bell, D. W.; Haber, D. A.; Settleman, J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways Science 2004, 305, 1163-1167
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 20
    • 33947541141 scopus 로고    scopus 로고
    • Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth
    • Li, Z.; Xu, M.; Xing, S.; Ho, W. T.; Ishii, T.; Li, Q.; Fu, X.; Zhao, Z. J. Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth J. Biol. Chem. 2007, 282, 3428-3432
    • (2007) J. Biol. Chem. , vol.282 , pp. 3428-3432
    • Li, Z.1    Xu, M.2    Xing, S.3    Ho, W.T.4    Ishii, T.5    Li, Q.6    Fu, X.7    Zhao, Z.J.8
  • 21
    • 34948845576 scopus 로고    scopus 로고
    • Lapatinib in the treatment of breast cancer
    • Higa, G. M.; Abraham, J. Lapatinib in the treatment of breast cancer Expert Rev. Anticancer Ther. 2007, 7, 1183-1192
    • (2007) Expert Rev. Anticancer Ther. , vol.7 , pp. 1183-1192
    • Higa, G.M.1    Abraham, J.2
  • 24
    • 0141528828 scopus 로고    scopus 로고
    • Chronic myeloid leukemia - Advances in biology and new approaches to treatment
    • Goldman, J. M.; Melo, J. V. Chronic myeloid leukemia - advances in biology and new approaches to treatment N. Engl. J. Med. 2003, 349, 1451-1464
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1451-1464
    • Goldman, J.M.1    Melo, J.V.2
  • 26
    • 21744450304 scopus 로고    scopus 로고
    • Abl inhibitor BMS354825 binding mode in Abelson kinase revealed by molecular docking studies
    • Gambacorti-Passerini, C.; Gasser, M.; Ahmed, S.; Assouline, S.; Scapozza, L. Abl inhibitor BMS354825 binding mode in Abelson kinase revealed by molecular docking studies Leukemia 2005, 19, 1267-1269
    • (2005) Leukemia , vol.19 , pp. 1267-1269
    • Gambacorti-Passerini, C.1    Gasser, M.2    Ahmed, S.3    Assouline, S.4    Scapozza, L.5
  • 27
    • 7244251613 scopus 로고    scopus 로고
    • Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
    • Clark, J. J.; Cools, J.; Curley, D. P.; Yu, J. C.; Lokker, N. A.; Giese, N. A.; Gilliland, D. G. Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518 Blood 2004, 104, 2867-2872
    • (2004) Blood , vol.104 , pp. 2867-2872
    • Clark, J.J.1    Cools, J.2    Curley, D.P.3    Yu, J.C.4    Lokker, N.A.5    Giese, N.A.6    Gilliland, D.G.7
  • 28
    • 84872514196 scopus 로고    scopus 로고
    • Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer
    • Nam, H. J.; Im, S. A.; Oh, D. Y.; Elvin, P.; Kim, H. P.; Yoon, Y. K.; Min, A.; Song, S. H.; Han, S. W.; Kim, T. Y.; Bang, Y. J. Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer Mol. Cancer Ther. 2013, 12, 16-26
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 16-26
    • Nam, H.J.1    Im, S.A.2    Oh, D.Y.3    Elvin, P.4    Kim, H.P.5    Yoon, Y.K.6    Min, A.7    Song, S.H.8    Han, S.W.9    Kim, T.Y.10    Bang, Y.J.11
  • 29
    • 77953289990 scopus 로고    scopus 로고
    • Bosutinib: A review of preclinical studies in chronic myelogenous leukaemia
    • Boschelli, F.; Arndt, K.; Gambacorti-Passerini, C. Bosutinib: a review of preclinical studies in chronic myelogenous leukaemia Eur. J. Cancer 2010, 46, 1781-1789
    • (2010) Eur. J. Cancer , vol.46 , pp. 1781-1789
    • Boschelli, F.1    Arndt, K.2    Gambacorti-Passerini, C.3
  • 30
    • 23044439051 scopus 로고    scopus 로고
    • Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
    • Raje, N.; Kumar, S.; Hideshima, T.; Roccaro, A.; Ishitsuka, K.; Yasui, H.; Shiraishi, N.; Chauhan, D.; Munshi, N. C.; Green, S. R.; Anderson, K. C. Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma Blood 2005, 106, 1042-1047
    • (2005) Blood , vol.106 , pp. 1042-1047
    • Raje, N.1    Kumar, S.2    Hideshima, T.3    Roccaro, A.4    Ishitsuka, K.5    Yasui, H.6    Shiraishi, N.7    Chauhan, D.8    Munshi, N.C.9    Green, S.R.10    Anderson, K.C.11
  • 32
    • 0035875023 scopus 로고    scopus 로고
    • Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity
    • Dawson, M. I.; Hobbs, P. D.; Peterson, V. J.; Leid, M.; Lange, C. W.; Feng, K. C.; Chen, G.; Gu, J.; Li, H.; Kolluri, S. K.; Zhang, X.; Zhang, Y.; Fontana, J. A. Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity Cancer Res. 2001, 61, 4723-4730
    • (2001) Cancer Res. , vol.61 , pp. 4723-4730
    • Dawson, M.I.1    Hobbs, P.D.2    Peterson, V.J.3    Leid, M.4    Lange, C.W.5    Feng, K.C.6    Chen, G.7    Gu, J.8    Li, H.9    Kolluri, S.K.10    Zhang, X.11    Zhang, Y.12    Fontana, J.A.13
  • 33
    • 66749178359 scopus 로고    scopus 로고
    • Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents
    • Dong, Y.; Shi, Q.; Liu, Y. N.; Wang, X.; Bastow, K. F.; Lee, K. H. Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents J. Med. Chem. 2009, 52, 3586-3590
    • (2009) J. Med. Chem. , vol.52 , pp. 3586-3590
    • Dong, Y.1    Shi, Q.2    Liu, Y.N.3    Wang, X.4    Bastow, K.F.5    Lee, K.H.6
  • 34
    • 33845976332 scopus 로고    scopus 로고
    • BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth
    • Yasui, H.; Hideshima, T.; Ikeda, H.; Jin, J.; Ocio, E. M.; Kiziltepe, T.; Okawa, Y.; Vallet, S.; Podar, K.; Ishitsuka, K.; Richardson, P. G.; Pargellis, C.; Moss, N.; Raje, N.; Anderson, K. C. BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth Br. J. Hamaetol. 2007, 136, 414-423
    • (2007) Br. J. Hamaetol. , vol.136 , pp. 414-423
    • Yasui, H.1    Hideshima, T.2    Ikeda, H.3    Jin, J.4    Ocio, E.M.5    Kiziltepe, T.6    Okawa, Y.7    Vallet, S.8    Podar, K.9    Ishitsuka, K.10    Richardson, P.G.11    Pargellis, C.12    Moss, N.13    Raje, N.14    Anderson, K.C.15
  • 35
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang, J.; Yang, P. L.; Gray, N. S. Targeting cancer with small molecule kinase inhibitors Nat. Rev. Cancer 2009, 9, 28-39
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 36
    • 84896728348 scopus 로고    scopus 로고
    • Scaffold mining of kinase hinge binders in crystal structure database
    • Xing, L.; Rai, B.; Lunney, E. A. Scaffold mining of kinase hinge binders in crystal structure database J. Comput.-Aided Mol. Des. 2014, 28, 13-23
    • (2014) J. Comput.-Aided Mol. Des. , vol.28 , pp. 13-23
    • Xing, L.1    Rai, B.2    Lunney, E.A.3
  • 37
    • 84867343363 scopus 로고    scopus 로고
    • Discovery of tyrosine kinase inhibitors by docking into an inactive kinase conformation generated by molecular dynamics
    • Zhao, H.; Huang, D.; Caflisch, A. Discovery of tyrosine kinase inhibitors by docking into an inactive kinase conformation generated by molecular dynamics ChemMedChem 2012, 7, 1983-90
    • (2012) ChemMedChem , vol.7 , pp. 1983-1990
    • Zhao, H.1    Huang, D.2    Caflisch, A.3
  • 39
    • 25844486965 scopus 로고    scopus 로고
    • Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives
    • Wang, T. C.; Chen, I. L.; Lu, P. J.; Wong, C. H.; Liao, C. H.; Tsiao, K. C.; Chang, K. M.; Chen, Y. L.; Tzeng, C. C. Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives Bioorg. Med. Chem. 2005, 13, 6045-6053
    • (2005) Bioorg. Med. Chem. , vol.13 , pp. 6045-6053
    • Wang, T.C.1    Chen, I.L.2    Lu, P.J.3    Wong, C.H.4    Liao, C.H.5    Tsiao, K.C.6    Chang, K.M.7    Chen, Y.L.8    Tzeng, C.C.9
  • 40
    • 40949138412 scopus 로고    scopus 로고
    • Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives
    • Tseng, C. H.; Chen, Y. L.; Lu, P. J.; Yang, C. N.; Tzeng, C. C. Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives Bioorg. Med. Chem. 2008, 16, 3153-3162
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 3153-3162
    • Tseng, C.H.1    Chen, Y.L.2    Lu, P.J.3    Yang, C.N.4    Tzeng, C.C.5
  • 42
    • 0042466637 scopus 로고    scopus 로고
    • Interdimer processing mechanism of procaspase-8 activation
    • Chang, D. W.; Xing, Z.; Capacio, V. L.; Peter, M. E.; Yang, X. Interdimer processing mechanism of procaspase-8 activation EMBO J. 2003, 22, 4132-4142
    • (2003) EMBO J. , vol.22 , pp. 4132-4142
    • Chang, D.W.1    Xing, Z.2    Capacio, V.L.3    Peter, M.E.4    Yang, X.5
  • 43
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song, M. S.; Salmena, L.; Pandolfi, P. P. The functions and regulation of the PTEN tumour suppressor Nat. Rev. Mol. Cell Biol. 2012, 13, 283-296
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 44
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • Tamura, M.; Gu, J.; Matsumoto, K.; Aota, S.; Parsons, R.; Yamada, K. M. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN Science 1998, 280, 1614-1617
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3    Aota, S.4    Parsons, R.5    Yamada, K.M.6
  • 47
    • 84884558125 scopus 로고    scopus 로고
    • Unravelling cancer stem cell potential
    • Beck, B.; Blanpain, C. Unravelling cancer stem cell potential Nat. Rev. Cancer 2013, 13, 727-738
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 727-738
    • Beck, B.1    Blanpain, C.2
  • 50
    • 60149101077 scopus 로고    scopus 로고
    • ALDH1 as a functional marker of cancer stem and progenitor cells
    • Douville, J.; Beaulieu, R.; Balicki, D. ALDH1 as a functional marker of cancer stem and progenitor cells Stem Cells Dev. 2009, 18, 17-25
    • (2009) Stem Cells Dev. , vol.18 , pp. 17-25
    • Douville, J.1    Beaulieu, R.2    Balicki, D.3
  • 51
    • 84877359648 scopus 로고    scopus 로고
    • CD133: A cancer stem cells marker, is used in colorectal cancers
    • Ren, F.; Sheng, W. Q.; Du, X. CD133: a cancer stem cells marker, is used in colorectal cancers World J. Gastroenterol. 2013, 19, 2603-2611
    • (2013) World J. Gastroenterol. , vol.19 , pp. 2603-2611
    • Ren, F.1    Sheng, W.Q.2    Du, X.3
  • 52
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P. B.; Onder, T. T.; Jiang, G.; Tao, K.; Kuperwasser, C.; Weinberg, R. A.; Lander, E. S. Identification of selective inhibitors of cancer stem cells by high-throughput screening Cell 2009, 138, 645-659
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 53
    • 77956268839 scopus 로고    scopus 로고
    • Understanding resistance to EGFR inhibitors-impact on future treatment strategies
    • Wheeler, D. L.; Dunn, E. F.; Harari, P. M. Understanding resistance to EGFR inhibitors-impact on future treatment strategies Nat. Rev. Clin. Oncol. 2010, 7, 493-507
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 493-507
    • Wheeler, D.L.1    Dunn, E.F.2    Harari, P.M.3
  • 54
    • 0037228832 scopus 로고    scopus 로고
    • Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways
    • Habib, A. A.; Chun, S. J.; Neel, B. G.; Vartanian, T. Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways Mol. Cancer Res. 2003, 1, 219-233
    • (2003) Mol. Cancer Res. , vol.1 , pp. 219-233
    • Habib, A.A.1    Chun, S.J.2    Neel, B.G.3    Vartanian, T.4
  • 55
    • 0033231070 scopus 로고    scopus 로고
    • Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism
    • Price, J. T.; Tiganis, T.; Agarwal, A.; Djakiew, D.; Thompson, E. W. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism Cancer Res. 1999, 59, 5475-5478
    • (1999) Cancer Res. , vol.59 , pp. 5475-5478
    • Price, J.T.1    Tiganis, T.2    Agarwal, A.3    Djakiew, D.4    Thompson, E.W.5
  • 56
    • 0036142749 scopus 로고    scopus 로고
    • Promigratory effect of plasminogen activator inhibitor-1 on invasive breast cancer cell populations
    • Chazaud, B.; Ricoux, R.; Christov, C.; Plonquet, A.; Gherardi, R. K.; Barlovatz-Meimon, G. Promigratory effect of plasminogen activator inhibitor-1 on invasive breast cancer cell populations Am. J. Pathol. 2002, 160, 237-246
    • (2002) Am. J. Pathol. , vol.160 , pp. 237-246
    • Chazaud, B.1    Ricoux, R.2    Christov, C.3    Plonquet, A.4    Gherardi, R.K.5    Barlovatz-Meimon, G.6
  • 57
    • 79956113945 scopus 로고    scopus 로고
    • Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer
    • Booy, E. P.; Henson, E. S.; Gibson, S. B. Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer Oncogene 2011, 30, 2367-2378
    • (2011) Oncogene , vol.30 , pp. 2367-2378
    • Booy, E.P.1    Henson, E.S.2    Gibson, S.B.3
  • 58
    • 84878647867 scopus 로고    scopus 로고
    • MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1
    • Gao, J.; Li, L.; Wu, M.; Liu, M.; Xie, X.; Guo, J.; Tang, H.; Xie, X. MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1 PLoS One 2013, 8, e65138
    • (2013) PLoS One , vol.8 , pp. 65138
    • Gao, J.1    Li, L.2    Wu, M.3    Liu, M.4    Xie, X.5    Guo, J.6    Tang, H.7    Xie, X.8
  • 60
    • 14944377114 scopus 로고    scopus 로고
    • Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs
    • Han, E. K.; McGonigal, T.; Wang, J.; Giranda, V. L.; Luo, Y. Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs Anticancer Res. 2004, 24, 3899-3905
    • (2004) Anticancer Res. , vol.24 , pp. 3899-3905
    • Han, E.K.1    McGonigal, T.2    Wang, J.3    Giranda, V.L.4    Luo, Y.5
  • 62
    • 84886095190 scopus 로고    scopus 로고
    • Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches
    • George, A. J.; Hannan, R. D.; Thomas, W. G. Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches FEBS J. 2013, 280, 5258-5268
    • (2013) FEBS J. , vol.280 , pp. 5258-5268
    • George, A.J.1    Hannan, R.D.2    Thomas, W.G.3
  • 64
    • 7444239715 scopus 로고    scopus 로고
    • Targeting ErbB receptor signaling: A pan-ErbB approach to cancer
    • Britten, C. D. Targeting ErbB receptor signaling: a pan-ErbB approach to cancer Mol. Cancer Ther. 2004, 3, 1335-1342
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1335-1342
    • Britten, C.D.1
  • 65
    • 35648965243 scopus 로고    scopus 로고
    • Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
    • Gong, Y.; Somwar, R.; Politi, K.; Balak, M.; Chmielecki, J.; Jiang, X.; Pao, W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas PLoS Med. 2007, 4, e294
    • (2007) PLoS Med. , vol.4 , pp. 294
    • Gong, Y.1    Somwar, R.2    Politi, K.3    Balak, M.4    Chmielecki, J.5    Jiang, X.6    Pao, W.7
  • 67
    • 33846274624 scopus 로고    scopus 로고
    • Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer
    • Yan, Y.; Lu, Y.; Wang, M.; Vikis, H.; Yao, R.; Wang, Y.; Lubet, R. A.; You, M. Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer Mol. Cancer Res. 2006, 4, 971-981
    • (2006) Mol. Cancer Res. , vol.4 , pp. 971-981
    • Yan, Y.1    Lu, Y.2    Wang, M.3    Vikis, H.4    Yao, R.5    Wang, Y.6    Lubet, R.A.7    You, M.8
  • 68
    • 84906789840 scopus 로고    scopus 로고
    • Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice
    • Boehmerle, W.; Muenzfeld, H.; Springer, A.; Huehnchen, P.; Endres, M. Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice J. Mol. Med. (Berlin) 2014, 92, 889-900
    • (2014) J. Mol. Med. (Berlin) , vol.92 , pp. 889-900
    • Boehmerle, W.1    Muenzfeld, H.2    Springer, A.3    Huehnchen, P.4    Endres, M.5
  • 69
    • 84879696870 scopus 로고    scopus 로고
    • Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice
    • Ojo, O. O.; Bhadauria, S.; Rath, S. K. Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice PLoS One 2013, 8, e69086
    • (2013) PLoS One , vol.8 , pp. 69086
    • Ojo, O.O.1    Bhadauria, S.2    Rath, S.K.3
  • 70
    • 0842325791 scopus 로고    scopus 로고
    • CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A
    • Manna, P. P.; Frazier, W. A. CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A Cancer Res. 2004, 64, 1026-1036
    • (2004) Cancer Res. , vol.64 , pp. 1026-1036
    • Manna, P.P.1    Frazier, W.A.2
  • 72
    • 84861986754 scopus 로고    scopus 로고
    • In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: Role of pro-apoptotic effects of oleanolic acid and urosolic acid
    • Chakravarti, B.; Maurya, R.; Siddiqui, J. A.; Bid, H. K.; Rajendran, S. M.; Yadav, P. P.; Konwar, R. In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: role of pro-apoptotic effects of oleanolic acid and urosolic acid J. Ethnopharmacol. 2012, 142, 72-79
    • (2012) J. Ethnopharmacol. , vol.142 , pp. 72-79
    • Chakravarti, B.1    Maurya, R.2    Siddiqui, J.A.3    Bid, H.K.4    Rajendran, S.M.5    Yadav, P.P.6    Konwar, R.7
  • 74
    • 70350681047 scopus 로고    scopus 로고
    • Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4
    • Byon, C. H.; Hardy, R. W.; Ren, C.; Ponnazhagan, S.; Welch, D. R.; McDonald, J. M.; Chen, Y. Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4 Lab. Invest. 2009, 89, 1221-1228
    • (2009) Lab. Invest. , vol.89 , pp. 1221-1228
    • Byon, C.H.1    Hardy, R.W.2    Ren, C.3    Ponnazhagan, S.4    Welch, D.R.5    McDonald, J.M.6    Chen, Y.7
  • 75
    • 0032713122 scopus 로고    scopus 로고
    • Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells
    • Jiang, W. G.; Hiscox, S. E.; Parr, C.; Martin, T. A.; Matsumoto, K.; Nakamura, T.; Mansel, R. E. Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells Clin. Cancer Res. 1999, 5, 3695-3703
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3695-3703
    • Jiang, W.G.1    Hiscox, S.E.2    Parr, C.3    Martin, T.A.4    Matsumoto, K.5    Nakamura, T.6    Mansel, R.E.7
  • 76
    • 34250777391 scopus 로고    scopus 로고
    • Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
    • Parr, C.; Sanders, A. J.; Davies, G.; Martin, T.; Lane, J.; Mason, M. D.; Mansel, R. E.; Jiang, W. G. Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients Clin. Cancer Res. 2007, 13, 3568-3576
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3568-3576
    • Parr, C.1    Sanders, A.J.2    Davies, G.3    Martin, T.4    Lane, J.5    Mason, M.D.6    Mansel, R.E.7    Jiang, W.G.8
  • 79
    • 0015177156 scopus 로고
    • A method for deriving kinetic constants for two enzymes acting on the same substrate
    • Spears, G.; Sneyd, J. G.; Loten, E. G. A method for deriving kinetic constants for two enzymes acting on the same substrate Biochem. J. 1971, 125, 1149-1151
    • (1971) Biochem. J. , vol.125 , pp. 1149-1151
    • Spears, G.1    Sneyd, J.G.2    Loten, E.G.3
  • 80
    • 77953691624 scopus 로고    scopus 로고
    • Phosphorylation of mouse serine racemase regulates D-serine synthesis
    • Foltyn, V. N.; Zehl, M.; Dikopoltsev, E.; Jensen, O. N.; Wolosker, H. Phosphorylation of mouse serine racemase regulates D-serine synthesis FEBS Lett. 2010, 584, 2937-2941
    • (2010) FEBS Lett. , vol.584 , pp. 2937-2941
    • Foltyn, V.N.1    Zehl, M.2    Dikopoltsev, E.3    Jensen, O.N.4    Wolosker, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.