BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth

British Journal of Haematology

Volumn 136, Issue 3, 2007, Pages 414-423

  Yasui, Hiroshi ^a,b   Hideshima, Teru ^a   Ikeda, Hiroshi ^a,b   Jin, Janice ^a   Ocio, Enrique M ^a   Kiziltepe, Tanyel ^a   Okawa, Yutaka ^a   Vallet, Sonia ^a   Podar, Klaus ^a   Ishitsuka, Kenji ^a   Richardson, Paul G ^a   Pargellis, Chris ^c   Moss, Neil ^c   Raje, Noopur ^a,d   Anderson, Kenneth C ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

BIRB 796; Bone marrow microenvironment; Heat shock protein; Multiple myeloma; p38 mitogen activated protein kinase

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; BORTEZOMIB; CANCER GROWTH FACTOR; CASPASE; DEXAMETHASONE; DORAMAPIMOD; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ARTICLE; BONE MARROW CELL; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MICROENVIRONMENT; MULTIPLE MYELOMA; MYELOMA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STROMA CELL; TUMOR CELL; TUMOR GROWTH; UPREGULATION;

ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; BENZOQUINONES; BORONIC ACIDS; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; COCULTURE TECHNIQUES; CYTOTOXICITY TESTS, IMMUNOLOGIC; DEXAMETHASONE; DRUG RESISTANCE, NEOPLASM; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-6; LACTAMS, MACROCYCLIC; MULTIPLE MYELOMA; NAPHTHALENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZINES; PYRAZOLES; SIGNAL TRANSDUCTION; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33845976332     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06443.x     Document Type: Article

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