Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice

Journal of Molecular Medicine

Volumn 92, Issue 8, 2014, Pages 889-900

  Boehmerle, Wolfgang ^a   Muenzfeld, Hanna ^a   Springer, Andreas ^c   Huehnchen, Petra ^a   Endres, Matthias ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Mitochondrial sodium calcium exchanger; Neuropathic pain; Pharmacokinetics; TRP channels

Indexed keywords

CALCIUM; SALINOMYCIN; SODIUM CALCIUM EXCHANGE PROTEIN; ANTINEOPLASTIC AGENT; PYRAN DERIVATIVE;

ACTION POTENTIAL; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; AVERSIVE BEHAVIOR; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CANCER STEM CELL; CONTROLLED STUDY; DORSAL ROOT; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GAIT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LONG TERM CARE; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MOTOR PERFORMANCE; MOUSE; NEUROLOGIC GAIT DISORDER; NEUROTOXICITY; NONHUMAN; PERIPHERAL NEUROPATHY; POLYNEUROPATHY; ROTAROD TEST; SCIATIC NERVE; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VOLUME OF DISTRIBUTION; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; MITOCHONDRION; MUSCLE; PATHOLOGY; PATHOPHYSIOLOGY; PILOT STUDY; SPINAL GANGLION; TOXICITY TESTING; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BEHAVIOR, ANIMAL; CELL LINE, TUMOR; GANGLIA, SPINAL; MALE; MICE; MITOCHONDRIA; MUSCLES; NEOPLASTIC STEM CELLS; PERIPHERAL NERVOUS SYSTEM DISEASES; PILOT PROJECTS; PYRANS; TOXICITY TESTS;

EID: 84906789840     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-014-1155-0     Document Type: Article

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