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Volumn 7, Issue 9, 2007, Pages 1183-1192

Lapatinib in the treatment of breast cancer

Author keywords

EGFR; ErbB family; HER2; Lapatinib; Receptor tyrosine kinase; Trastuzumab

Indexed keywords

ANTHRACYCLINE DERIVATIVE; AROMATASE INHIBITOR; CAPECITABINE; CETUXIMAB; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; FLUOROPYRIMIDINE; GEFITINIB; IMATINIB; IRINOTECAN; LAPATINIB; LETROZOLE; PACLITAXEL; PLACEBO; TAXANE DERIVATIVE; TRASTUZUMAB; TYVERB; UNCLASSIFIED DRUG;

EID: 34948845576     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.7.9.1183     Document Type: Review
Times cited : (123)

References (61)
  • 1
    • 0002053552 scopus 로고
    • Estrogen receptors in hormone-responsive tissues and tumors
    • Wissler RW, Dao TL, Wood S Jr Eds, University of Chicago Press, IL, USA
    • Jensen EV, DeSombre ER, Jungblut PW. Estrogen receptors in hormone-responsive tissues and tumors. In: Endogenous Factors Influencing Host-Tumor Balance. Wissler RW, Dao TL, Wood S Jr (Eds). University of Chicago Press, IL, USA 15-30 (1967).
    • (1967) Endogenous Factors Influencing Host-Tumor Balance , pp. 15-30
    • Jensen, E.V.1    DeSombre, E.R.2    Jungblut, P.W.3
  • 2
    • 0003224009 scopus 로고
    • The minute chromosome (Ph1) in chronic granulocytic leukemia
    • Nowell PC. The minute chromosome (Ph1) in chronic granulocytic leukemia. Blut 8, 65-66 (1962).
    • (1962) Blut , vol.8 , pp. 65-66
    • Nowell, P.C.1
  • 3
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/ neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/ neu oncogene. Science 235(4785), 177-182 (1987).
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 4
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1673-1684 (2005).
    • (2005) N. Engl. J. Med , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 5
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1659-1672 (2005).
    • (2005) N. Engl. J. Med , vol.353 , Issue.16 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 6
    • 33645792831 scopus 로고    scopus 로고
    • Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy
    • Montemurro F, Donadio M, Clavarezza M et al. Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy. Oncologist 11(4), 318-324 (2006).
    • (2006) Oncologist , vol.11 , Issue.4 , pp. 318-324
    • Montemurro, F.1    Donadio, M.2    Clavarezza, M.3
  • 7
    • 33645538673 scopus 로고    scopus 로고
    • Analysis of trastuzumab and chemotherapy in advanced breast cancer after the failure of at least one earlier combination: An observational study
    • Bartsch R, Wenzel C, Hussian D et al. Analysis of trastuzumab and chemotherapy in advanced breast cancer after the failure of at least one earlier combination: an observational study. BMC Cancer 6, 63-68 (2006).
    • (2006) BMC Cancer , vol.6 , pp. 63-68
    • Bartsch, R.1    Wenzel, C.2    Hussian, D.3
  • 8
    • 28344441711 scopus 로고    scopus 로고
    • Trastuzumab associated with successive cytotoxic therapies beyond disease progression in metastatic breast cancer
    • Garcia-Saenz JA, Martin M, Puente J et al. Trastuzumab associated with successive cytotoxic therapies beyond disease progression in metastatic breast cancer. Clin. Breast Cancer 6, 325-329 (2005).
    • (2005) Clin. Breast Cancer , vol.6 , pp. 325-329
    • Garcia-Saenz, J.A.1    Martin, M.2    Puente, J.3
  • 9
    • 3042676349 scopus 로고    scopus 로고
    • Use of trastuzumab beyond disease progression: Observations from a retrospective review of case histories
    • Gelmon KA, Mackey J, Verma S et al. Use of trastuzumab beyond disease progression: observations from a retrospective review of case histories. Clin. Breast Cancer 5(1), 52-58 (2004).
    • (2004) Clin. Breast Cancer , vol.5 , Issue.1 , pp. 52-58
    • Gelmon, K.A.1    Mackey, J.2    Verma, S.3
  • 10
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N. Engl. J. Med. 355(26), 2733-2743 (2006).
    • (2006) N. Engl. J. Med , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 11
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103(2), 211-225 (2000).
    • (2000) Cell , vol.103 , Issue.2 , pp. 211-225
    • Schlessinger, J.1
  • 12
    • 0037291226 scopus 로고    scopus 로고
    • The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation poised to interact with other ErbB receptors
    • Garrett TP, McKern NM, Lou M et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation poised to interact with other ErbB receptors. Mol. Cell 11(2), 495-505 (2003).
    • (2003) Mol. Cell , vol.11 , Issue.2 , pp. 495-505
    • Garrett, T.P.1    McKern, N.M.2    Lou, M.3
  • 13
    • 0033542381 scopus 로고    scopus 로고
    • Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation
    • Jones FE, Stern DF. Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation. Oncogene 18(23), 3481-3490 (1999).
    • (1999) Oncogene , vol.18 , Issue.23 , pp. 3481-3490
    • Jones, F.E.1    Stern, D.F.2
  • 14
    • 0033523775 scopus 로고    scopus 로고
    • ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation
    • Jones FE, Welte T, Fu XY, Stern DF. ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J. Cell Biol. 147(1), 77-87 (1999).
    • (1999) J. Cell Biol , vol.147 , Issue.1 , pp. 77-87
    • Jones, F.E.1    Welte, T.2    Fu, X.Y.3    Stern, D.F.4
  • 16
    • 0024355092 scopus 로고
    • Autocrine interaction between TGF α and the EGF-receptor: Quantitative requirements for induction of the malignant phenotype
    • Di Marco E, Pierce JH, Fleming TP et al. Autocrine interaction between TGF α and the EGF-receptor: quantitative requirements for induction of the malignant phenotype. Oncogene 4(7), 831-838 (1989).
    • (1989) Oncogene , vol.4 , Issue.7 , pp. 831-838
    • Di Marco, E.1    Pierce, J.H.2    Fleming, T.P.3
  • 17
    • 0027517374 scopus 로고
    • Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study Group
    • Seshadri R, Firgaira FA, Horsfall DJ, McCaul K, Setlur V, Kitchen P. Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study Group. J. Clin. Oncol. 11(10), 1936-1942 (1993).
    • (1993) J. Clin. Oncol , vol.11 , Issue.10 , pp. 1936-1942
    • Seshadri, R.1    Firgaira, F.A.2    Horsfall, D.J.3    McCaul, K.4    Setlur, V.5    Kitchen, P.6
  • 18
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J. Clin. Oncol. 20(3), 719-726 (2002).
    • (2002) J. Clin. Oncol , vol.20 , Issue.3 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 19
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 17(9), 2639-2648 (1999).
    • (1999) J. Clin. Oncol , vol.17 , Issue.9 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 20
    • 0036534121 scopus 로고    scopus 로고
    • Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
    • Esteva FJ, Valero V, Booser D et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J. Clin. Oncol. 20(7), 1800-1808 (2002).
    • (2002) J. Clin. Oncol , vol.20 , Issue.7 , pp. 1800-1808
    • Esteva, F.J.1    Valero, V.2    Booser, D.3
  • 21
    • 0041885349 scopus 로고    scopus 로고
    • Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: Multicenter Phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm
    • Burstein HJ, Harris LN, Marcom PK et al. Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter Phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J. Clin. Oncol. 21(15), 2889-2895 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.15 , pp. 2889-2895
    • Burstein, H.J.1    Harris, L.N.2    Marcom, P.K.3
  • 22
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344(11), 783-792 (2001).
    • (2001) N. Engl. J. Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 23
    • 4644289313 scopus 로고    scopus 로고
    • A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
    • Wood ER, Truesdale AT, McDonald OB et al. A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 64(18), 6652-6659 (2004).
    • (2004) Cancer Res , vol.64 , Issue.18 , pp. 6652-6659
    • Wood, E.R.1    Truesdale, A.T.2    McDonald, O.B.3
  • 24
    • 23944476155 scopus 로고    scopus 로고
    • Phase I study, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
    • Burris HA III, Hurwitz HI, Dees EC et al. Phase I study, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol. 23(23), 5305-5313 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.23 , pp. 5305-5313
    • Burris III, H.A.1    Hurwitz, H.I.2    Dees, E.C.3
  • 25
    • 2942592008 scopus 로고    scopus 로고
    • Dual kinase inhibition in the treatment of breast cancer: Initial experience with the EGFR/ErbB-2 inhibitor lapatinib
    • Burris HA 3rd. Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist 9 (Suppl. 3), 10-15 (2004).
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 3 , pp. 10-15
    • Burris 3rd, H.A.1
  • 26
    • 0029912203 scopus 로고    scopus 로고
    • All erbB receptors other than the epidermal growth factor receptor are endocytosis impaired
    • Baulida J, Kraus MH, Alimandi M, Di Fiore PP, Carpenter G. All erbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem. 271(9), 5251-5257 (1996).
    • (1996) J. Biol. Chem , vol.271 , Issue.9 , pp. 5251-5257
    • Baulida, J.1    Kraus, M.H.2    Alimandi, M.3    Di Fiore, P.P.4    Carpenter, G.5
  • 27
    • 0032526729 scopus 로고    scopus 로고
    • Differential endocytic routing of homo- and hetero-dimeric erbB tyrosine kinases confers signaling superiority to receptor heterodimers
    • Lenferink AEG, Pinkas-Kramarski R, van de Poll MLM et al. Differential endocytic routing of homo- and hetero-dimeric erbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17(12), 3385-3397 (1998).
    • (1998) EMBO J , vol.17 , Issue.12 , pp. 3385-3397
    • Lenferink, A.E.G.1    Pinkas-Kramarski, R.2    van de Poll, M.L.M.3
  • 28
    • 20844437246 scopus 로고    scopus 로고
    • Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects
    • Bence AK, Anderson EB, Halepota MA et al. Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects. Invest. New Drugs 23(1), 39-49 (2005).
    • (2005) Invest. New Drugs , vol.23 , Issue.1 , pp. 39-49
    • Bence, A.K.1    Anderson, E.B.2    Halepota, M.A.3
  • 29
    • 34948909630 scopus 로고    scopus 로고
    • Lapatinib (L) plus capecitabine (C) in HER2+ advanced breast cancer (ABC): Genomic and updated efficacy data
    • Geyer CE, Martin A, Newstat B et al. Lapatinib (L) plus capecitabine (C) in HER2+ advanced breast cancer (ABC): genomic and updated efficacy data. Proc. Am. Soc. Clin. Oncol. 25(Suppl. 18), 1035 (2007).
    • (2007) Proc. Am. Soc. Clin. Oncol , vol.25 , Issue.SUPPL. 18 , pp. 1035
    • Geyer, C.E.1    Martin, A.2    Newstat, B.3
  • 30
    • 34047248199 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in breast cancer
    • Sonpavde G. Lapatinib plus capecitabine in breast cancer. N. Engl. J. Med. 356(14), 1471-1472 (2007).
    • (2007) N. Engl. J. Med , vol.356 , Issue.14 , pp. 1471-1472
    • Sonpavde, G.1
  • 31
    • 34047248199 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in breast cancer
    • Geyer CE, Forster J, Cameron MD. Lapatinib plus capecitabine in breast cancer. N. Engl. J. Med. 356(14), 1471-1472 (2007).
    • (2007) N. Engl. J. Med , vol.356 , Issue.14 , pp. 1471-1472
    • Geyer, C.E.1    Forster, J.2    Cameron, M.D.3
  • 32
    • 30544440228 scopus 로고    scopus 로고
    • Interim results of a Phase II randomized study of lapatinib (GW572016) as first-line treatment for patients with FISH-amplified advanced or metastatic breast cancer
    • Stein SH, Gomez HL, Chavez MA et al. Interim results of a Phase II randomized study of lapatinib (GW572016) as first-line treatment for patients with FISH-amplified advanced or metastatic breast cancer. Eur. J. Cancer 3(Suppl.), 78 (2005).
    • (2005) Eur. J. Cancer , vol.3 , Issue.SUPPL. , pp. 78
    • Stein, S.H.1    Gomez, H.L.2    Chavez, M.A.3
  • 33
    • 34250655315 scopus 로고    scopus 로고
    • Cardiac safety experience in 3127 patients treated with lapatinib
    • Perez EA, Byrne JA, Hammond IW et al. Cardiac safety experience in 3127 patients treated with lapatinib. Ann. Oncol. 17(Suppl. 9), 1420 (2006).
    • (2006) Ann. Oncol , vol.17 , Issue.SUPPL. 9 , pp. 1420
    • Perez, E.A.1    Byrne, J.A.2    Hammond, I.W.3
  • 34
    • 0033838655 scopus 로고    scopus 로고
    • Incidence and epidemiology of heart failure
    • Kannel WB. Incidence and epidemiology of heart failure. Heart Fail. Rev. 5(2), 167-173 (2000).
    • (2000) Heart Fail. Rev , vol.5 , Issue.2 , pp. 167-173
    • Kannel, W.B.1
  • 35
    • 34948911758 scopus 로고    scopus 로고
    • Preclinical study of continuous administration trastuzumab as combination therapy after disease progresses with trastuzumab monotherapy
    • Fujimoto-Ouchi K, Sekiguchi F, More I. Preclinical study of continuous administration trastuzumab as combination therapy after disease progresses with trastuzumab monotherapy. Proc. Am. Assoc. Cancer Res. 46, 5062 (2005).
    • (2005) Proc. Am. Assoc. Cancer Res , vol.46 , pp. 5062
    • Fujimoto-Ouchi, K.1    Sekiguchi, F.2    More, I.3
  • 36
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351(4), 337-345 (2004).
    • (2004) N. Engl. J. Med , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 37
    • 22344446208 scopus 로고    scopus 로고
    • Randomized Phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
    • Marty M, Cognetti F, Maraninchi D et al. Randomized Phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J. Clin. Oncol. 23(19), 4265-4274 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.19 , pp. 4265-4274
    • Marty, M.1    Cognetti, F.2    Maraninchi, D.3
  • 38
    • 12744279331 scopus 로고    scopus 로고
    • Increased risk of brain metastasis in patients with HER-2/neu- positive breast carcinoma
    • Altaha R, Crowell E, Hobbs G, Higa G, Abraham J. Increased risk of brain metastasis in patients with HER-2/neu- positive breast carcinoma. Cancer 103(3), 442-443 (2005).
    • (2005) Cancer , vol.103 , Issue.3 , pp. 442-443
    • Altaha, R.1    Crowell, E.2    Hobbs, G.3    Higa, G.4    Abraham, J.5
  • 39
    • 34948902249 scopus 로고    scopus 로고
    • Brain metastases (BM) in patients treated with trastuzumab for HER overexpressing metastatic breast cancer (MBC): Incidence and survival
    • Abstract 1568
    • Stemmler J, Kahlert S. Siekiera W et al. Brain metastases (BM) in patients treated with trastuzumab for HER overexpressing metastatic breast cancer (MBC): incidence and survival. J. Clin. Oncol. 23(Suppl. 16), Abstract 1568 (2005).
    • (2005) J. Clin. Oncol , Issue.SUPPL. 16 , pp. 23
    • Stemmler, J.1    Kahlert, S.2    Siekiera, W.3
  • 40
    • 33746512271 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer
    • Part I, Abstract 503
    • Lin NU, Carey LA, Liu MC et al. Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer. J. Clin. Oncol. 24(Suppl. 18, Part I) (2006) (Abstract 503).
    • (2006) J. Clin. Oncol , Issue.SUPPL. 18 , pp. 24
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3
  • 41
    • 34848899905 scopus 로고    scopus 로고
    • EGF105084, a Phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT)
    • Lin NU, Dieras V, Paul D et al. EGF105084, a Phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT). Proc. Am. Soc. Clin. Oncol. 25(Suppl. 18), 1012 (2007).
    • (2007) Proc. Am. Soc. Clin. Oncol , vol.25 , Issue.SUPPL. 18 , pp. 1012
    • Lin, N.U.1    Dieras, V.2    Paul, D.3
  • 42
    • 10044242769 scopus 로고    scopus 로고
    • Cardiac dysfunction induced by trastuzumab
    • Campone M, Bourbouloux E, Fumoleau P. Cardiac dysfunction induced by trastuzumab. Bull. Cancer 91 (Suppl. 3), 166-173 (2004).
    • (2004) Bull. Cancer , vol.91 , Issue.SUPPL. 3 , pp. 166-173
    • Campone, M.1    Bourbouloux, E.2    Fumoleau, P.3
  • 43
    • 9644310269 scopus 로고    scopus 로고
    • Inhibition of erbB2 causes mitochondrial dysfunction in cardiomyocytes: Implications for herceptin-induced cardiomyopathy
    • Grazette LP, Boecker W, Matsui T et al. Inhibition of erbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J. Am. Coll. Cardiol. 44(11), 2231-2238 (2004).
    • (2004) J. Am. Coll. Cardiol , vol.44 , Issue.11 , pp. 2231-2238
    • Grazette, L.P.1    Boecker, W.2    Matsui, T.3
  • 44
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
    • Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 61(24), 8887-8895 (2001).
    • (2001) Cancer Res , vol.61 , Issue.24 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, F.M.2    Muthuswamy, S.K.3    Bianco, R.4    Simpson, J.F.5    Arteaga, C.L.6
  • 45
    • 33644626501 scopus 로고    scopus 로고
    • ECOG E1100: a Phase II trial of trastuzumab and gefitinib in patients with metastatic breast cancer that overexpress HER2/neu (erbB-2). Clin. Adv. Hematol. Oncol. 1, 237 (2003).
    • ECOG E1100: a Phase II trial of trastuzumab and gefitinib in patients with metastatic breast cancer that overexpress HER2/neu (erbB-2). Clin. Adv. Hematol. Oncol. 1, 237 (2003).
  • 46
    • 23944464495 scopus 로고    scopus 로고
    • Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer
    • Baselga J, Albanell J, Ruiz A et al. Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J. Clin. Oncol. 23(23), 5323-5233 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.23 , pp. 5323-5233
    • Baselga, J.1    Albanell, J.2    Ruiz, A.3
  • 48
    • 0036848757 scopus 로고    scopus 로고
    • Prognostic and predictive value of epidermal growth factor receptor in recurrent breast cancer
    • Tsutsui S, Kataoka A, Ohno S, Murakami S, Kinoshita J, Hachitanda Y. Prognostic and predictive value of epidermal growth factor receptor in recurrent breast cancer. Clin. Cancer Res. 8(11), 3454-3460 (2002).
    • (2002) Clin. Cancer Res , vol.8 , Issue.11 , pp. 3454-3460
    • Tsutsui, S.1    Kataoka, A.2    Ohno, S.3    Murakami, S.4    Kinoshita, J.5    Hachitanda, Y.6
  • 49
    • 20844456577 scopus 로고    scopus 로고
    • A multicentre Phase II study on geftinib in taxane- and anthracycline-pretreated metastatic breast cancer
    • von Minckwitz G, Jonat W, Fasching P et al. A multicentre Phase II study on geftinib in taxane- and anthracycline-pretreated metastatic breast cancer. Breast Cancer Res. Treat. 89(2), 165-172 (2005).
    • (2005) Breast Cancer Res. Treat , vol.89 , Issue.2 , pp. 165-172
    • von Minckwitz, G.1    Jonat, W.2    Fasching, P.3
  • 50
    • 33749011681 scopus 로고    scopus 로고
    • A Phase I study of cetuximab/ paclitaxel in patients with advanced-stage breast cancer
    • Modi S, D'Andrea G, Norton L et al. A Phase I study of cetuximab/ paclitaxel in patients with advanced-stage breast cancer. Clin. Breast Cancer 7(3), 270-277 (2006).
    • (2006) Clin. Breast Cancer , vol.7 , Issue.3 , pp. 270-277
    • Modi, S.1    D'Andrea, G.2    Norton, L.3
  • 51
    • 0029053716 scopus 로고
    • Cooperative signaling of erbB3 and erbB2 in neoplastic transformation and human mammary carcinomas
    • Alimandi M, Romano A, Curia MC et al. Cooperative signaling of erbB3 and erbB2 in neoplastic transformation and human mammary carcinomas. Oncogene 10(9), 1813-1821 (1995).
    • (1995) Oncogene , vol.10 , Issue.9 , pp. 1813-1821
    • Alimandi, M.1    Romano, A.2    Curia, M.C.3
  • 52
    • 0024395587 scopus 로고
    • Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts
    • Kokai Y, Myers JN, Wada T et al. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 58(2), 287-292 (1989).
    • (1989) Cell , vol.58 , Issue.2 , pp. 287-292
    • Kokai, Y.1    Myers, J.N.2    Wada, T.3
  • 53
    • 1242273590 scopus 로고    scopus 로고
    • Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual. EGFR/ErbB2 kinase inhibitor GW72016
    • Xia W, Liu L-H, Ho P, Spector NL. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual. EGFR/ErbB2 kinase inhibitor GW72016. Oncogene 23(3), 646-653 (2004).
    • (2004) Oncogene , vol.23 , Issue.3 , pp. 646-653
    • Xia, W.1    Liu, L.-H.2    Ho, P.3    Spector, N.L.4
  • 54
    • 0023733226 scopus 로고
    • Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene
    • Segatto O, King CR, Pierce JH, DiFiore PP, Aaronson SA. Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene. Mol. Cell Biol. 8(12), 5570-5574 (1988).
    • (1988) Mol. Cell Biol , vol.8 , Issue.12 , pp. 5570-5574
    • Segatto, O.1    King, C.R.2    Pierce, J.H.3    DiFiore, P.P.4    Aaronson, S.A.5
  • 55
    • 0034082031 scopus 로고    scopus 로고
    • Circulating HER2 extracellular domain and resistance to chemotherapy in advanced breast cancer
    • Colomer R, Montero S, Lluch A et al. Circulating HER2 extracellular domain and resistance to chemotherapy in advanced breast cancer. Clin. Cancer Res. 6(6), 2356-2362 (2000).
    • (2000) Clin. Cancer Res , vol.6 , Issue.6 , pp. 2356-2362
    • Colomer, R.1    Montero, S.2    Lluch, A.3
  • 56
    • 0036187710 scopus 로고    scopus 로고
    • 2-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
    • 2-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin. Cancer Res. 8(2), 347-353 (2002).
    • (2002) Clin. Cancer Res , vol.8 , Issue.2 , pp. 347-353
    • Molina, M.A.1    Saez, R.2    Ramsey3
  • 57
    • 20144377465 scopus 로고    scopus 로고
    • HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells
    • Hirata A, Hosoi F, Miyagawa M et al. HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. Cancer Res. 65(10), 4253-4260 (2005).
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4253-4260
    • Hirata, A.1    Hosoi, F.2    Miyagawa, M.3
  • 58
    • 0037388251 scopus 로고    scopus 로고
    • Anido J, Matar P, Albanell J et al. ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER-overexpressing breast cancer cells. Clin. Cancer Res. 9(4), 1274-1283 (2003).
    • Anido J, Matar P, Albanell J et al. ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER-overexpressing breast cancer cells. Clin. Cancer Res. 9(4), 1274-1283 (2003).
  • 59
    • 0031010495 scopus 로고    scopus 로고
    • Secondary dimerization between members of the epidermal growth factor receptor family
    • Gamett DC, Pearson G, Cerione RA, Friedberg I. Secondary dimerization between members of the epidermal growth factor receptor family. J. Biol. Chem. 272(18), 12052-12056 (1997).
    • (1997) J. Biol. Chem , vol.272 , Issue.18 , pp. 12052-12056
    • Gamett, D.C.1    Pearson, G.2    Cerione, R.A.3    Friedberg, I.4
  • 60
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science 267(5205), 1782-1788 (1995).
    • (1995) Science , vol.267 , Issue.5205 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 61
    • 4544376914 scopus 로고    scopus 로고
    • Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor erbB-2
    • Wang SC, Lien HC, Xia W et al. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor erbB-2. Cancer Cell 6(3), 251-261 (2004).
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 251-261
    • Wang, S.C.1    Lien, H.C.2    Xia, W.3


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