-
1
-
-
79955019148
-
The atypical 16p11.2 deletion: a not so atypical microdeletion syndrome?
-
Barge-Schaapveld DQ, Maas SM, Polstra A, Knegt LC&Hennekam RC 2011 The atypical 16p11.2 deletion: a not so atypical microdeletion syndrome? American Journal of Medical Genetics. Part A 155A 1066-1072. (doi:10.1002/ajmg.a.33991)
-
(2011)
American Journal of Medical Genetics. Part A
, vol.155 A
, pp. 1066-1072
-
-
Barge-Schaapveld, D.Q.1
Maas, S.M.2
Polstra, A.3
Knegt, L.C.4
Hennekam, R.C.5
-
2
-
-
76349083132
-
Large, rare chromosomal deletions associated with severe early-onset obesity
-
Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S et al. 2010 Large, rare chromosomal deletions associated with severe early-onset obesity. Nature 463 666-670. (doi:10.1038/nature08689)
-
(2010)
Nature
, vol.463
, pp. 666-670
-
-
Bochukova, E.G.1
Huang, N.2
Keogh, J.3
Henning, E.4
Purmann, C.5
Blaszczyk, K.6
Saeed, S.7
Hamilton-Shield, J.8
Clayton-Smith, J.9
O'Rahilly, S.10
-
3
-
-
77956020769
-
SH2B1 - the adaptor protein that could
-
Chua S Jr 2010 SH2B1 - the adaptor protein that could. Endocrinology 151 4100-4102. (doi:10.1210/en.2010-0572)
-
(2010)
Endocrinology
, vol.151
, pp. 4100-4102
-
-
Chua, S.1
-
4
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [see comments]
-
Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM et al. 1998 A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [see comments]. Nature 392 398-401. (doi:10.1038/32911)
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
Cabrol, S.4
Pelloux, V.5
Cassuto, D.6
Gourmelen, M.7
Dina, C.8
Chambaz, J.9
Lacorte, J.M.10
-
5
-
-
0018355535
-
Obesity genes: beneficial effects in heterozygous mice
-
Coleman DL 1979 Obesity genes: beneficial effects in heterozygous mice. Science 203 663-665. (doi:10.1126/science.760211)
-
(1979)
Science
, vol.203
, pp. 663-665
-
-
Coleman, D.L.1
-
6
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans [see comments]
-
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL et al. 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans [see comments]. New England Journal of Medicine 334 292-295. (doi:10.1056/NEJM199602013340503)
-
(1996)
New England Journal of Medicine
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.4
Stephens, T.W.5
Nyce, M.R.6
Ohannesian, J.P.7
Marco, C.C.8
McKee, L.J.9
Bauer, T.L.10
-
7
-
-
84870541022
-
Human SH2B1 mutations are associated with maladaptive behaviors and obesity
-
Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Dale A, Cheetham T, Barroso I et al. 2012 Human SH2B1 mutations are associated with maladaptive behaviors and obesity. Journal of Clinical Investigation 122 4732-4736. (doi:10.1172/JCI62696)
-
(2012)
Journal of Clinical Investigation
, vol.122
, pp. 4732-4736
-
-
Doche, M.E.1
Bochukova, E.G.2
Su, H.W.3
Pearce, L.R.4
Keogh, J.M.5
Henning, E.6
Cline, J.M.7
Dale, A.8
Cheetham, T.9
Barroso, I.10
-
8
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA&O'Rahilly S 1999 Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 341 879-884. (doi:10.1056/NEJM199909163411204)
-
(1999)
New England Journal of Medicine
, vol.341
, pp. 879-884
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
Lawrence, E.4
Cheetham, C.H.5
Prentice, A.M.6
Hughes, I.A.7
McCamish, M.A.8
O'Rahilly, S.9
-
9
-
-
0035514934
-
Partial leptin deficiency and human adiposity
-
Farooqi IS, Keogh JM, Kamath S, Jones S, Gibson WT, Trussell R, Jebb SA, Lip GY&O'Rahilly S 2001 Partial leptin deficiency and human adiposity. Nature 414 34-35. (doi:10.1038/35102112)
-
(2001)
Nature
, vol.414
, pp. 34-35
-
-
Farooqi, I.S.1
Keogh, J.M.2
Kamath, S.3
Jones, S.4
Gibson, W.T.5
Trussell, R.6
Jebb, S.A.7
Lip, G.Y.8
O'Rahilly, S.9
-
10
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S et al. 2002 Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Journal of Clinical Investigation 110 1093-1103. (doi:10.1172/JCI0215693)
-
(2002)
Journal of Clinical Investigation
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
Keogh, J.M.4
Lawrence, E.5
Agwu, C.6
Sanna, V.7
Jebb, S.A.8
Perna, F.9
Fontana, S.10
-
11
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T&O'Rahilly S 2003 Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. New England Journal of Medicine 348 1085-1095. (doi:10.1056/NEJMoa022050)
-
(2003)
New England Journal of Medicine
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.3
Lank, E.J.4
Cheetham, T.5
O'Rahilly, S.6
-
12
-
-
33750592655
-
Heterozygosity for a POMC-null mutation and increased obesity risk in humans
-
Farooqi IS, Drop S, Clements A, Keogh JM, Biernacka J, Lowenbein S, Challis BG&O'Rahilly S 2006 Heterozygosity for a POMC-null mutation and increased obesity risk in humans. Diabetes 55 2549-2553. (doi:10.2337/db06-0214)
-
(2006)
Diabetes
, vol.55
, pp. 2549-2553
-
-
Farooqi, I.S.1
Drop, S.2
Clements, A.3
Keogh, J.M.4
Biernacka, J.5
Lowenbein, S.6
Challis, B.G.7
O'Rahilly, S.8
-
13
-
-
33846409122
-
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
-
Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I et al. 2007a Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. New England Journal of Medicine 356 237-247. (doi:10.1056/NEJMoa063988)
-
(2007)
New England Journal of Medicine
, vol.356
, pp. 237-247
-
-
Farooqi, I.S.1
Wangensteen, T.2
Collins, S.3
Kimber, W.4
Matarese, G.5
Keogh, J.M.6
Lank, E.7
Bottomley, B.8
Lopez-Fernandez, J.9
Ferraz-Amaro, I.10
-
14
-
-
34548675339
-
Leptin regulates striatal regions and human eating behavior
-
Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S&Fletcher PC 2007b Leptin regulates striatal regions and human eating behavior. Science 317 1355. (doi:10.1126/science.1144599)
-
(2007)
Science
, vol.317
, pp. 1355
-
-
Farooqi, I.S.1
Bullmore, E.2
Keogh, J.3
Gillard, J.4
O'Rahilly, S.5
Fletcher, P.C.6
-
15
-
-
79961217238
-
Leptin therapy in a congenital leptindeficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas
-
Frank S, Heni M, Moss A, von Schnurbein J, Fritsche A, Haring HU, Farooqi S, Preissl H&Wabitsch M 2011 Leptin therapy in a congenital leptindeficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas. Journal of Clinical Endocrinology and Metabolism 96 E1283-E1287. (doi:10.1210/jc.2010-2713)
-
(2011)
Journal of Clinical Endocrinology and Metabolism
, vol.96
, pp. E1283-E1287
-
-
Frank, S.1
Heni, M.2
Moss, A.3
von Schnurbein, J.4
Fritsche, A.5
Haring, H.U.6
Farooqi, S.7
Preissl, H.8
Wabitsch, M.9
-
16
-
-
76149128662
-
Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients
-
Galgani JE, Greenway FL, Caglayan S, Wong ML, Licinio J&Ravussin E 2010 Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. Journal of Clinical Endocrinology and Metabolism 95 851-855. (doi:10.1210/jc.2009-1739)
-
(2010)
Journal of Clinical Endocrinology and Metabolism
, vol.95
, pp. 851-855
-
-
Galgani, J.E.1
Greenway, F.L.2
Caglayan, S.3
Wong, M.L.4
Licinio, J.5
Ravussin, E.6
-
17
-
-
6344221594
-
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy
-
Gibson WT, Farooqi IS, Moreau M, DePaoli AM, Lawrence E, O'Rahilly S & Trussell RA 2004 Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. Journal of Clinical Endocrinology and Metabolism 89 4821-4826. (doi:10.1210/jc.2004-0376)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, pp. 4821-4826
-
-
Gibson, W.T.1
Farooqi, I.S.2
Moreau, M.3
DePaoli, A.M.4
Lawrence, E.5
O'Rahilly, S.6
Trussell, R.A.7
-
18
-
-
58249087146
-
Modulation of blood pressure by central melanocortinergic pathways
-
Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC et al. 2009 Modulation of blood pressure by central melanocortinergic pathways. New England Journal of Medicine 360 44-52. (doi:10.1056/NEJMoa0803085)
-
(2009)
New England Journal of Medicine
, vol.360
, pp. 44-52
-
-
Greenfield, J.R.1
Miller, J.W.2
Keogh, J.M.3
Henning, E.4
Satterwhite, J.H.5
Cameron, G.S.6
Astruc, B.7
Mayer, J.P.8
Brage, S.9
See, T.C.10
-
19
-
-
0035172040
-
Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
-
Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjoorbaek C, Elmquist JK, Flier JS&Hollenberg AN 2001 Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. Journal of Clinical Investigation 107 111-120. (doi:10.1172/JCI10741)
-
(2001)
Journal of Clinical Investigation
, vol.107
, pp. 111-120
-
-
Harris, M.1
Aschkenasi, C.2
Elias, C.F.3
Chandrankunnel, A.4
Nillni, E.A.5
Bjoorbaek, C.6
Elmquist, J.K.7
Flier, J.S.8
Hollenberg, A.N.9
-
20
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD et al. 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 131-141. (doi:10.1016/S0092-8674(00)81865-6)
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
-
21
-
-
0032578453
-
Abnormal regulation of the leptin gene in the pathogenesis of obesity
-
Ioffe E, Moon B, Connolly E&Friedman JM 1998 Abnormal regulation of the leptin gene in the pathogenesis of obesity. PNAS 95 11851-11852.
-
(1998)
PNAS
, vol.95
, pp. 11851-11852
-
-
Ioffe, E.1
Moon, B.2
Connolly, E.3
Friedman, J.M.4
-
22
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene [see comments]
-
Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, Montague CT, Hutton JC&O'Rahilly S 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene [see comments]. Nature Genetics 16 303-306. (doi:10.1038/ng0797-303)
-
(1997)
Nature Genetics
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
Raffin-Sanson, M.L.4
Sanders, L.5
Montague, C.T.6
Hutton, J.C.7
O'Rahilly, S.8
-
23
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude H, Biebermann H, Luck W, Horn R, Brabant G&Gruters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genetics 19 155-157. (doi:10.1038/509)
-
(1998)
Nature Genetics
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
Horn, R.4
Brabant, G.5
Gruters, A.6
-
24
-
-
0242320429
-
Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10
-
Krude H, Biebermann H, Schnabel D, Tansek MZ, Theunissen P, Mullis PE & Gruters A 2003 Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.Journal of Clinical Endocrinology and Metabolism 88 4633-4640. (doi:10.1210/jc.2003-030502)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, pp. 4633-4640
-
-
Krude, H.1
Biebermann, H.2
Schnabel, D.3
Tansek, M.Z.4
Theunissen, P.5
Mullis, P.E.6
Gruters, A.7
-
25
-
-
0033861080
-
Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass
-
Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M et al. 2000 Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes 49 1347-1352. (doi:10.2337/diabetes.49.8.1347)
-
(2000)
Diabetes
, vol.49
, pp. 1347-1352
-
-
Lahlou, N.1
Clement, K.2
Carel, J.C.3
Vaisse, C.4
Lotton, C.5
Le Bihan, Y.6
Basdevant, A.7
Lebouc, Y.8
Froguel, P.9
Roger, M.10
-
26
-
-
12144289998
-
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
-
Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, Whitby R, Liang L, Cohen P, Bhasin S et al. 2004 Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. PNAS 101 4531-4536. (doi:10.1073/pnas.0308767101)
-
(2004)
PNAS
, vol.101
, pp. 4531-4536
-
-
Licinio, J.1
Caglayan, S.2
Ozata, M.3
Yildiz, B.O.4
de Miranda, P.B.5
O'Kirwan, F.6
Whitby, R.7
Liang, L.8
Cohen, P.9
Bhasin, S.10
-
27
-
-
0028845877
-
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S et al. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1 1155-1161. (doi:10.1038/nm1195-1155)
-
(1995)
Nature Medicine
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
Pratley, R.E.4
Lee, G.H.5
Zhang, Y.6
Fei, H.7
Kim, S.8
Lallone, R.9
Ranganathan, S.10
-
28
-
-
17844366295
-
Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans
-
Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S, Elashoff RM, Cogswell RJ, Negro P, Liberty V et al. 2001 Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. Journal of Clinical Endocrinology and Metabolism 86 3284-3291. (doi:10.1210/jcem.86.7.7644)
-
(2001)
Journal of Clinical Endocrinology and Metabolism
, vol.86
, pp. 3284-3291
-
-
Mantzoros, C.S.1
Ozata, M.2
Negrao, A.B.3
Suchard, M.A.4
Ziotopoulou, M.5
Caglayan, S.6
Elashoff, R.M.7
Cogswell, R.J.8
Negro, P.9
Liberty, V.10
-
29
-
-
78650912045
-
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion
-
Martinelli CE, Keogh JM, Greenfield JR, Henning E, van der Klaauw AA, Blackwood A, O'Rahilly S, Roelfsema F, Camacho-Hubner C, Pijl H et al. 2011 Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion. Journal of Clinical Endocrinology and Metabolism 96 E181-E188. (doi:10.1210/jc.2010-1369)
-
(2011)
Journal of Clinical Endocrinology and Metabolism
, vol.96
, pp. E181-E188
-
-
Martinelli, C.E.1
Keogh, J.M.2
Greenfield, J.R.3
Henning, E.4
van der Klaauw, A.A.5
Blackwood, A.6
O'Rahilly, S.7
Roelfsema, F.8
Camacho-Hubner, C.9
Pijl, H.10
-
30
-
-
33845663497
-
SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other
-
Maures TJ, Kurzer JH&Carter-Su C 2007 SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other. Trends in Endocrinology and Metabolism 18 38-45. (doi:10.1016/j.tem.2006.11.007)
-
(2007)
Trends in Endocrinology and Metabolism
, vol.18
, pp. 38-45
-
-
Maures, T.J.1
Kurzer, J.H.2
Carter-Su, C.3
-
31
-
-
67649908458
-
A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient
-
Mazen I, El-Gammal M, Abdel-Hamid M&Amr K 2009 A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient. Molecular Genetics and Metabolism 97 305-308. (doi:10.1016/j.ymgme.2009.04.002)
-
(2009)
Molecular Genetics and Metabolism
, vol.97
, pp. 305-308
-
-
Mazen, I.1
El-Gammal, M.2
Abdel-Hamid, M.3
Amr, K.4
-
32
-
-
79952631516
-
Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity
-
Mazen I, El-Gammal M, Abdel-Hamid M, Farooqi IS&Amr K 2011 Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity. Molecular Genetics and Metabolism 102 461-464. (doi:10.1016/j.ymgme.2010.12.013)
-
(2011)
Molecular Genetics and Metabolism
, vol.102
, pp. 461-464
-
-
Mazen, I.1
El-Gammal, M.2
Abdel-Hamid, M.3
Farooqi, I.S.4
Amr, K.5
-
33
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMPactivated protein kinase
-
Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D&Kahn BB 2002 Leptin stimulates fatty-acid oxidation by activating AMPactivated protein kinase. Nature 415 339-343. (doi:10.1038/415339a)
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
Fryer, L.G.4
Muller, C.5
Carling, D.6
Kahn, B.B.7
-
34
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA et al. 1997 Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387 903-908. (doi:10.1038/43185)
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
Sewter, C.P.7
Digby, J.E.8
Mohammed, S.N.9
Hurst, J.A.10
-
35
-
-
70349086181
-
SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins
-
Morris DL, Cho KW, Zhou Y&Rui L 2009 SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. Diabetes 58 2039-2047. (doi:10.2337/db08-1388)
-
(2009)
Diabetes
, vol.58
, pp. 2039-2047
-
-
Morris, D.L.1
Cho, K.W.2
Zhou, Y.3
Rui, L.4
-
36
-
-
0034680925
-
Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways
-
Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjorbak C&Flier JS 2000 Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. Journal of Biological Chemistry 275 36124-36133. (doi:10.1074/jbc.M003549200)
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 36124-36133
-
-
Nillni, E.A.1
Vaslet, C.2
Harris, M.3
Hollenberg, A.4
Bjorbak, C.5
Flier, J.S.6
-
37
-
-
0037148928
-
Leptin-replacement therapy for lipodystrophy
-
Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI et al. 2002 Leptin-replacement therapy for lipodystrophy. New England Journal of Medicine 346 570-578. (doi:10.1056/NEJMoa012437)
-
(2002)
New England Journal of Medicine
, vol.346
, pp. 570-578
-
-
Oral, E.A.1
Simha, V.2
Ruiz, E.3
Andewelt, A.4
Premkumar, A.5
Snell, P.6
Wagner, A.J.7
DePaoli, A.M.8
Reitman, M.L.9
Taylor, S.I.10
-
38
-
-
0033304576
-
Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
-
Ozata M, Ozdemir IC&Licinio J 1999 Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. Journal of Clinical Endocrinology and Metabolism 84 3686-3695. (doi:10.1210/jcem.84.10.5999)
-
(1999)
Journal of Clinical Endocrinology and Metabolism
, vol.84
, pp. 3686-3695
-
-
Ozata, M.1
Ozdemir, I.C.2
Licinio, J.3
-
39
-
-
0031050415
-
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
-
Ravussin E, Pratley RE, Maffei M, Wang H, Friedman JM, Bennett PH & Bogardus C 1997 Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nature Medicine 3 238-240. (doi:10.1038/nm0297-238)
-
(1997)
Nature Medicine
, vol.3
, pp. 238-240
-
-
Ravussin, E.1
Pratley, R.E.2
Maffei, M.3
Wang, H.4
Friedman, J.M.5
Bennett, P.H.6
Bogardus, C.7
-
40
-
-
33846822094
-
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
-
Ren D, Zhou Y, Morris D, Li M, Li Z&Rui L 2007 Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. Journal of Clinical Investigation 117 397-406. (doi:10.1172/JCI29417)
-
(2007)
Journal of Clinical Investigation
, vol.117
, pp. 397-406
-
-
Ren, D.1
Zhou, Y.2
Morris, D.3
Li, M.4
Li, Z.5
Rui, L.6
-
41
-
-
0036093071
-
Low dose leptin administration reverses effects of sustained weightreduction on energy expenditure and circulating concentrations of thyroid hormones
-
Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE&Leibel RL 2002 Low dose leptin administration reverses effects of sustained weightreduction on energy expenditure and circulating concentrations of thyroid hormones. Journal of Clinical Endocrinology and Metabolism 87 2391-2394. (doi:10.1210/jcem.87.5.8628)
-
(2002)
Journal of Clinical Endocrinology and Metabolism
, vol.87
, pp. 2391-2394
-
-
Rosenbaum, M.1
Murphy, E.M.2
Heymsfield, S.B.3
Matthews, D.E.4
Leibel, R.L.5
-
42
-
-
31044444463
-
Lowdose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
-
Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E&Leibel RL 2005 Lowdose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. Journal of Clinical Investigation 115 3579-3586. (doi:10.1172/JCI25977)
-
(2005)
Journal of Clinical Investigation
, vol.115
, pp. 3579-3586
-
-
Rosenbaum, M.1
Goldsmith, R.2
Bloomfield, D.3
Magnano, A.4
Weimer, L.5
Heymsfield, S.6
Gallagher, D.7
Mayer, L.8
Murphy, E.9
Leibel, R.L.10
-
43
-
-
46749099010
-
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
-
Rosenbaum M, Sy M, Pavlovich K, Leibel RL&Hirsch J 2008 Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. Journal of Clinical Investigation 118 2583-2591. (doi:10.1172/JCI35055)
-
(2008)
Journal of Clinical Investigation
, vol.118
, pp. 2583-2591
-
-
Rosenbaum, M.1
Sy, M.2
Pavlovich, K.3
Leibel, R.L.4
Hirsch, J.5
-
44
-
-
84860211766
-
High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families
-
Saeed S, Butt TA, Anwer M, Arslan M&Froguel P 2012 High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Molecular Genetics and Metabolism 106 121-126. (doi:10.1016/j.ymgme.2012.03.001)
-
(2012)
Molecular Genetics and Metabolism
, vol.106
, pp. 121-126
-
-
Saeed, S.1
Butt, T.A.2
Anwer, M.3
Arslan, M.4
Froguel, P.5
-
45
-
-
84859916102
-
Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism
-
von Schnurbein J, Moss A, Nagel SA, Muehleder H, Debatin KM, Farooqi IS & Wabitsch M 2012 Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism. Hormone Research in Paediatrics 77 127-133. (doi:10.1159/000336003)
-
(2012)
Hormone Research in Paediatrics
, vol.77
, pp. 127-133
-
-
von Schnurbein, J.1
Moss, A.2
Nagel, S.A.3
Muehleder, H.4
Debatin, K.M.5
Farooqi, I.S.6
Wabitsch, M.7
-
46
-
-
84879421084
-
Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptindeficient girl
-
von Schnurbein J, Heni M, Moss A, Nagel SA, Machann J, Muehleder H, Debatin KM, Farooqi S&Wabitsch M 2013 Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptindeficient girl. Hormone Research in Paediatrics 79 310-317. (doi:10.1159/000348541)
-
(2013)
Hormone Research in Paediatrics
, vol.79
, pp. 310-317
-
-
von Schnurbein, J.1
Heni, M.2
Moss, A.3
Nagel, S.A.4
Machann, J.5
Muehleder, H.6
Debatin, K.M.7
Farooqi, S.8
Wabitsch, M.9
-
47
-
-
0032014836
-
A leptin missense mutation associated with hypogonadismand morbid obesity
-
Strobel A, Issad T, Camoin L, Ozata M&Strosberg AD 1998 A leptin missense mutation associated with hypogonadismand morbid obesity. Nature Genetics 18 213-215. (doi:10.1038/ng0398-213)
-
(1998)
Nature Genetics
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozata, M.4
Strosberg, A.D.5
-
48
-
-
52749092130
-
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees
-
Stutzmann F, Tan K, Vatin V, Dina C, Jouret B, Tichet J, Balkau B, Potoczna N, Horber F, O'Rahilly S et al. 2008 Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. Diabetes 57 2511-2518. (doi:10.2337/db08-0153)
-
(2008)
Diabetes
, vol.57
, pp. 2511-2518
-
-
Stutzmann, F.1
Tan, K.2
Vatin, V.3
Dina, C.4
Jouret, B.5
Tichet, J.6
Balkau, B.7
Potoczna, N.8
Horber, F.9
O'Rahilly, S.10
-
49
-
-
77951663638
-
CNS leptin action modulates immune response and survival in sepsis
-
Tschop J, Nogueiras R, Haas-Lockie S, Kasten KR, Castaneda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N et al. 2010 CNS leptin action modulates immune response and survival in sepsis. Journal of Neuroscience 30 6036-6047. (doi:10.1523/JNEUROSCI.4875-09.2010)
-
(2010)
Journal of Neuroscience
, vol.30
, pp. 6036-6047
-
-
Tschop, J.1
Nogueiras, R.2
Haas-Lockie, S.3
Kasten, K.R.4
Castaneda, T.R.5
Huber, N.6
Guanciale, K.7
Perez-Tilve, D.8
Habegger, K.9
Ottaway, N.10
-
50
-
-
0033927916
-
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B&Froguel P 2000 Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. Journal of Clinical Investigation 106 253-262. (doi:10.1172/JCI9238)
-
(2000)
Journal of Clinical Investigation
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
Hercberg, S.4
Guy-Grand, B.5
Froguel, P.6
-
51
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L&Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432. (doi:10.1038/372425a0)
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
|