Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 8, 2011, Pages

  Frank, Sabine ^a,b   Heni, Martin ^a,c   Moss, Anja ^d   Von Schnurbein, Julia ^d   Fritsche, Andreas ^a,c   Häring, Hans Ulrich ^a,c   Farooqi, Sadaf ^e   Preissl, Hubert ^a,f   Wabitsch, Martin ^d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^d UNIVERSITY OF ULM   (Germany)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; METRELEPTIN; UNCLASSIFIED DRUG;

ADOLESCENT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CALORIE; CASE REPORT; CORPUS STRIATUM; FEEDING BEHAVIOR; FEMALE; FOOD; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HOMEOSTASIS; HORMONE DEFICIENCY; HUMAN; HYPOTHALAMUS; LEPTIN DEFICIENCY; ORBITAL CORTEX; PRIORITY JOURNAL; REWARD; SUBSTANTIA NIGRA; TREATMENT RESPONSE; VENTRAL TEGMENTUM; VISUAL STIMULATION;

ACUTE DISEASE; ADOLESCENT; AMYGDALA; BRAIN; FEEDING BEHAVIOR; FEMALE; FRONTAL LOBE; HOMEOSTASIS; HUMANS; HYPERPHAGIA; LEPTIN; MAGNETIC RESONANCE IMAGING; OBESITY; REWARD; SATIETY RESPONSE; SUBSTANTIA NIGRA; TIME; VENTRAL TEGMENTAL AREA;

EID: 79961217238     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2010-2713     Document Type: Article

References (18)

1. Farooqi S, O'Rahilly S 2006 Genetics of obesity in humans. Endocr Rev 27:710-718 (Pubitemid 44936054)
2. Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, Whitby R, Liang L, Cohen P, Bhasin S, Krauss RM, Veldhuis JD, Wagner AJ, DePaoli AM, McCann SM, Wong ML 2004 Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci USA 101:4531-4536 (Pubitemid 38437445)
3. Galgani JE, Greenway FL, Caglayan S, Wong ML, Licinio J, Ravussin E 2010 Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. J Clin Endocrinol Metab 95:851-855
4. Williams KW, Scott MM, Elmquist JK 2009 From observation to experimentation: leptin action in the mediobasal hypothalamus. Am J Clin Nutr 89:985S-990S
5. Leshan RL, Opland DM, Louis GW, Leinninger GM, Patterson CM, Rhodes CJ,Münzberg H, Myers Jr MG 2010 Ventral tegmental arealeptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci 30:5713-5723
6. Morrison CD 2009 Leptin signaling in brain: a link between nutrition and cognition? Biochim Biophys Acta 1792:401-408
7. Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J 2008 Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest 118:2583-2591 (Pubitemid 351949785)
8. Baicy K, London ED, Monterosso J, Wong ML, Delibasi T, Sharma A, Licinio J 2007 Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc Natl Acad Sci USA 104:18276-18279 (Pubitemid 350210857)
9. Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC 2007 Leptin regulates striatal regions and human eating behavior. Science 317:1355 (Pubitemid 47417470)
10. Fischer-Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, Barth TF, Kassubek J, Mühleder H, Möller P, Debatin KM,Gierschik P, Wabitsch M 2010 A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab 95:2836-2840
11. Frank S, Laharnar N, Kullmann S, Veit R, Canova C, Hegner YL, Fritsche A, Preissl H 2010 Processing of food pictures: influence of hunger, gender and calorie content. Brain Res 1350:159-166
12. Czyzewska M, Graham R 2008 Implicit and explicit attitudes to high- and low-calorie food in females with different BMI status. Eat Behav 9:303-312 (Pubitemid 351784378)
13. Narayanan NS, Guarnieri DJ, DiLeone RJ 2010 Metabolic hormones, dopamine circuits, and feeding. Front Neuroendocrinol 31:104-112
14. Smeets PA, de Graaf C, Stafleu A, van Osch MJ, van der Grond J 2005 Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories. Am J Clin Nutr 82:1011-1016 (Pubitemid 43779758)
15. Kampe J, Tschöp MH, Hollis JH, Oldfield BJ 2009 An anatomicbasis for the communication of hypothalamic, cortical and mesolimbic circuitry in the regulation of energy balance. Eur J Neurosci 30:415-430
16. Grill HJ, Skibicka KP, Hayes MR 2007 Imaging obesity: fMRI, food reward, and feeding. Cell Metab 6:423-425 (Pubitemid 350163057)
17. DiLeone RJ 2009 The influence of leptin on the dopamine system and implications for ingestive behavior. Int J Obes (Lond) 33(Suppl 2):S25-S29
18. Batterink L, Yokum S, Stice E 2010 Body mass correlates inversely with inhibitory control in response to food among adolescent girls: an fMRI study. Neuroimage 52:1696-1703