메뉴 건너뛰기




Volumn 59, Issue 31, 2014, Pages 4030-4040

Recent advances in brown adipose tissue biology

Author keywords

Anti obesity; Batokine; Beige adipocyte; Brown adipose tissue; Energy regulation

Indexed keywords


EID: 84907861110     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-014-0386-3     Document Type: Article
Times cited : (3)

References (137)
  • 1
    • 34347326271 scopus 로고    scopus 로고
    • Transcriptional control of brown fat determination by PRDM16
    • Seale P, Kajimura S, Yang W et al (2007) Transcriptional control of brown fat determination by PRDM16. Cell Metab 6:38–54
    • (2007) Cell Metab , vol.6 , pp. 38-54
    • Seale, P.1    Kajimura, S.2    Yang, W.3
  • 2
    • 0031040576 scopus 로고    scopus 로고
    • Brown adipose tissue, beta 3-adrenergic receptors, and obesity
    • Lowell BB, Flier JS (1997) Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu Rev Med 48:307–316
    • (1997) Annu Rev Med , vol.48 , pp. 307-316
    • Lowell, B.B.1    Flier, J.S.2
  • 3
    • 50049127055 scopus 로고    scopus 로고
    • New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    • Tseng YH, Kokkotou E, Schulz TJ et al (2008) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454:1000–1004
    • (2008) Nature , vol.454 , pp. 1000-1004
    • Tseng, Y.H.1    Kokkotou, E.2    Schulz, T.J.3
  • 4
    • 70649109834 scopus 로고    scopus 로고
    • Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism
    • Schulz TJ, Tseng YH (2009) Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev 20:523–531
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 523-531
    • Schulz, T.J.1    Tseng, Y.H.2
  • 5
    • 79953660441 scopus 로고    scopus 로고
    • Renaissance of brown adipose tissue
    • Tews D, Wabitsch M (2011) Renaissance of brown adipose tissue. Horm Res Paediatr 75:231–239
    • (2011) Horm Res Paediatr , vol.75 , pp. 231-239
    • Tews, D.1    Wabitsch, M.2
  • 6
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84:277–359
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 7
    • 35348874911 scopus 로고    scopus 로고
    • Developmental origin of fat: tracking obesity to its source
    • Gesta S, Tseng YH, Kahn CR (2007) Developmental origin of fat: tracking obesity to its source. Cell 131:242–256
    • (2007) Cell , vol.131 , pp. 242-256
    • Gesta, S.1    Tseng, Y.H.2    Kahn, C.R.3
  • 8
    • 42649144463 scopus 로고    scopus 로고
    • Beneficial effects of subcutaneous fat transplantation on metabolism
    • Tran TT, Yamamoto Y, Gesta S et al (2008) Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 7:410–420
    • (2008) Cell Metab , vol.7 , pp. 410-420
    • Tran, T.T.1    Yamamoto, Y.2    Gesta, S.3
  • 9
    • 77449084188 scopus 로고    scopus 로고
    • Fat and aging-a tale of two tissues
    • Zafon C (2009) Fat and aging-a tale of two tissues. Curr Aging Sci 2:83–94
    • (2009) Curr Aging Sci , vol.2 , pp. 83-94
    • Zafon, C.1
  • 10
    • 78649955475 scopus 로고    scopus 로고
    • Body fat distribution and inflammation among obese older adults with and without metabolic syndrome
    • Koster A, Stenholm S, Alley DE et al (2010) Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring) 18:2354–2361
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 2354-2361
    • Koster, A.1    Stenholm, S.2    Alley, D.E.3
  • 11
    • 0031802865 scopus 로고    scopus 로고
    • Leptin secretion from subcutaneous and visceral adipose tissue in women
    • Van Harmelen V, Reynisdottir S, Eriksson P et al (1998) Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 47:913–917
    • (1998) Diabetes , vol.47 , pp. 913-917
    • Van Harmelen, V.1    Reynisdottir, S.2    Eriksson, P.3
  • 12
    • 2442438710 scopus 로고    scopus 로고
    • Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects
    • Lihn AS, Bruun JM, He G et al (2004) Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects. Mol Cell Endocrinol 219:9–15
    • (2004) Mol Cell Endocrinol , vol.219 , pp. 9-15
    • Lihn, A.S.1    Bruun, J.M.2    He, G.3
  • 13
    • 34347233419 scopus 로고    scopus 로고
    • Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
    • Kloting N, Graham TE, Berndt J et al (2007) Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab 6:79–87
    • (2007) Cell Metab , vol.6 , pp. 79-87
    • Kloting, N.1    Graham, T.E.2    Berndt, J.3
  • 14
    • 17844393870 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT
    • Bruun JM, Lihn AS, Pedersen SB et al (2005) Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab 90:2282–2289
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2282-2289
    • Bruun, J.M.1    Lihn, A.S.2    Pedersen, S.B.3
  • 15
    • 0348048487 scopus 로고    scopus 로고
    • Higher production of IL-8 in visceral versus subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue
    • Bruun JM, Lihn AS, Madan AK et al (2004) Higher production of IL-8 in visceral versus subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue. Am J Physiol Endocrinol Metab 286:8–13
    • (2004) Am J Physiol Endocrinol Metab , vol.286 , pp. 8-13
    • Bruun, J.M.1    Lihn, A.S.2    Madan, A.K.3
  • 16
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M et al (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3
  • 17
    • 79956318109 scopus 로고    scopus 로고
    • Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation
    • Hagita S, Osaka M, Shimokado K et al (2011) Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation. PLoS One 6:e19871
    • (2011) PLoS One , vol.6 , pp. e19871
    • Hagita, S.1    Osaka, M.2    Shimokado, K.3
  • 18
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G et al (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509–1517
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 19
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt A, Bruns OT, Reimer R et al (2011) Brown adipose tissue activity controls triglyceride clearance. Nat Med 17:200–205
    • (2011) Nat Med , vol.17 , pp. 200-205
    • Bartelt, A.1    Bruns, O.T.2    Reimer, R.3
  • 20
    • 84881221754 scopus 로고    scopus 로고
    • Recruited brown adipose tissue as an antiobesity agent in humans
    • Yoneshiro T, Aita S, Matsushita M et al (2013) Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 123:3404–3408
    • (2013) J Clin Invest , vol.123 , pp. 3404-3408
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3
  • 21
    • 84856529575 scopus 로고    scopus 로고
    • Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
    • Ouellet V, Labbé SM, Blondin DP et al (2012) Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 122:545–552
    • (2012) J Clin Invest , vol.122 , pp. 545-552
    • Ouellet, V.1    Labbé, S.M.2    Blondin, D.P.3
  • 22
    • 84878678150 scopus 로고    scopus 로고
    • Brown adipose tissue transplantation improves whole-body energy metabolism
    • Liu X, Zheng Z, Zhu X et al (2013) Brown adipose tissue transplantation improves whole-body energy metabolism. Cell Res 23:851–854
    • (2013) Cell Res , vol.23 , pp. 851-854
    • Liu, X.1    Zheng, Z.2    Zhu, X.3
  • 23
    • 84873854027 scopus 로고    scopus 로고
    • Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
    • Stanford KI, Middelbeek RJ, Townsend KL et al (2013) Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 123:215–223
    • (2013) J Clin Invest , vol.123 , pp. 215-223
    • Stanford, K.I.1    Middelbeek, R.J.2    Townsend, K.L.3
  • 24
    • 84885941568 scopus 로고    scopus 로고
    • Browning of white adipose tissue: role of hypothalamic signaling
    • Bi S, Li L (2013) Browning of white adipose tissue: role of hypothalamic signaling. Ann N Y Acad Sci 1302:30–34
    • (2013) Ann N Y Acad Sci , vol.1302 , pp. 30-34
    • Bi, S.1    Li, L.2
  • 25
    • 0022499231 scopus 로고
    • Brown adipose tissue uncoupling protein content in human infants, children and adults
    • Lean ME, James WP, Jennings G et al (1986) Brown adipose tissue uncoupling protein content in human infants, children and adults. Clin Sci (Lond) 71:291–297
    • (1986) Clin Sci (Lond) , vol.71 , pp. 291-297
    • Lean, M.E.1    James, W.P.2    Jennings, G.3
  • 26
    • 0018580712 scopus 로고
    • Regulation of energy balance in two models of reversible obesity in the rat
    • Rothwell NJ, Stock MJ (1979) Regulation of energy balance in two models of reversible obesity in the rat. J Comp Physiol Psychol 93:1024–1034
    • (1979) J Comp Physiol Psychol , vol.93 , pp. 1024-1034
    • Rothwell, N.J.1    Stock, M.J.2
  • 27
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell NJ, Stock MJ (1979) A role for brown adipose tissue in diet-induced thermogenesis. Nature 281:31–35
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 28
    • 84879427668 scopus 로고    scopus 로고
    • Brown adipose tissue activity after a high-calorie meal in humans
    • Vosselman MJ, Brans B, van der Lans AA et al (2013) Brown adipose tissue activity after a high-calorie meal in humans. Am J Clin Nutr 98:57–64
    • (2013) Am J Clin Nutr , vol.98 , pp. 57-64
    • Vosselman, M.J.1    Brans, B.2    van der Lans, A.A.3
  • 29
    • 84907860436 scopus 로고
    • Conradi Gesneri Medici Tigurine Historiae Animalium Lib
    • Gessner K (1551) Conradi Gesneri Medici Tigurine Historiae Animalium Lib. I De Quadripedibus Uiuiparis
    • (1551) I De Quadripedibus Uiuiparis
    • Gessner, K.1
  • 30
    • 84874403110 scopus 로고    scopus 로고
    • Control and physiological determinants of sympathetically mediated brown adipose tissue thermogenesis
    • Richard D, Monge-Roffarello B, Chechi K et al (2012) Control and physiological determinants of sympathetically mediated brown adipose tissue thermogenesis. Front Endocrinol (Lausanne) 3:36
    • (2012) Front Endocrinol (Lausanne) , vol.3 , pp. 36
    • Richard, D.1    Monge-Roffarello, B.2    Chechi, K.3
  • 31
    • 0017817970 scopus 로고
    • Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation
    • Heaton GM, Wagenvoord RJ, Kemp A Jr et al (1978) Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur J Biochem 82:515–521
    • (1978) Eur J Biochem , vol.82 , pp. 515-521
    • Heaton, G.M.1    Wagenvoord, R.J.2    Kemp, A.3
  • 32
    • 0022379399 scopus 로고
    • Mitochondrial uncoupling protein from mouse brown fat molecular cloning, genetic mapping, and mRNA expression
    • Jacobsson A, Stadler U, Glotzer MA et al (1985) Mitochondrial uncoupling protein from mouse brown fat molecular cloning, genetic mapping, and mRNA expression. J Biol Chem 260:16250–16254
    • (1985) J Biol Chem , vol.260 , pp. 16250-16254
    • Jacobsson, A.1    Stadler, U.2    Glotzer, M.A.3
  • 33
    • 0033969421 scopus 로고    scopus 로고
    • Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism
    • Boss O, Hagen T, Lowell BB (2000) Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes 49:143–156
    • (2000) Diabetes , vol.49 , pp. 143-156
    • Boss, O.1    Hagen, T.2    Lowell, B.B.3
  • 34
    • 0027731309 scopus 로고
    • Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    • Lowell BB, S-Susulic V, Hamann A et al (1993) Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366:740–742
    • (1993) Nature , vol.366 , pp. 740-742
    • Lowell, B.B.1    S-Susulic, V.2    Hamann, A.3
  • 35
    • 0031958087 scopus 로고    scopus 로고
    • Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice
    • Melnyk A, Himms-Hagen J (1998) Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice. Am J Physiol 274:R1131–R1135
    • (1998) Am J Physiol , vol.274 , pp. R1131-R1135
    • Melnyk, A.1    Himms-Hagen, J.2
  • 36
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B et al (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9:203–209
    • (2009) Cell Metab , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3
  • 37
    • 0033000588 scopus 로고    scopus 로고
    • Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential
    • Baumruk F, Flachs P, Horáková M et al (1999) Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential. FEBS Lett 444:206–210
    • (1999) FEBS Lett , vol.444 , pp. 206-210
    • Baumruk, F.1    Flachs, P.2    Horáková, M.3
  • 38
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell BB, Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404:652–660
    • (2000) Nature , vol.404 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 39
    • 78650676545 scopus 로고    scopus 로고
    • Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men
    • Yoneshiro T, Aita S, Matsushita M et al (2011) Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity (Silver Spring) 19:13–16
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 13-16
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3
  • 40
    • 78650945931 scopus 로고    scopus 로고
    • Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    • Seale P, Conroe HM, Estall J et al (2011) Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 121:96–105
    • (2011) J Clin Invest , vol.121 , pp. 96-105
    • Seale, P.1    Conroe, H.M.2    Estall, J.3
  • 41
    • 84893371365 scopus 로고    scopus 로고
    • Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
    • Wang J, Liu R, Wang F et al (2013) Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol 15:1455–1463
    • (2013) Nat Cell Biol , vol.15 , pp. 1455-1463
    • Wang, J.1    Liu, R.2    Wang, F.3
  • 42
    • 77952970098 scopus 로고    scopus 로고
    • Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
    • Vegiopoulos A, Müller-Decker K, Strzoda D et al (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328:1158–1161
    • (2010) Science , vol.328 , pp. 1158-1161
    • Vegiopoulos, A.1    Müller-Decker, K.2    Strzoda, D.3
  • 43
    • 84865747655 scopus 로고    scopus 로고
    • Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer
    • Nishio M, Yoneshiro T, Nakahara M et al (2012) Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab 16:394–406
    • (2012) Cell Metab , vol.16 , pp. 394-406
    • Nishio, M.1    Yoneshiro, T.2    Nakahara, M.3
  • 44
    • 79960945989 scopus 로고    scopus 로고
    • Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    • Orava J, Nuutila P, Lidell ME et al (2011) Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 14:272–279
    • (2011) Cell Metab , vol.14 , pp. 272-279
    • Orava, J.1    Nuutila, P.2    Lidell, M.E.3
  • 45
    • 0028832692 scopus 로고
    • Norepinephrine stimulates the expression of fibroblast growth factor 2 in rat brown adipocyte primary culture
    • Yamashita H, Sato N, Kizaki T et al (1995) Norepinephrine stimulates the expression of fibroblast growth factor 2 in rat brown adipocyte primary culture. Cell Growth Differ 6:1457–1462
    • (1995) Cell Growth Differ , vol.6 , pp. 1457-1462
    • Yamashita, H.1    Sato, N.2    Kizaki, T.3
  • 46
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares E, Iglesias R, Giralt A et al (2011) Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem 286:12983–12990
    • (2011) J Biol Chem , vol.286 , pp. 12983-12990
    • Hondares, E.1    Iglesias, R.2    Giralt, A.3
  • 48
    • 0343035670 scopus 로고    scopus 로고
    • β-Adrenergic stimulation of interleukin-1α and interleukin-6 expression in mouse brown adipocytes
    • Burýsek L, Houstek J (1997) β-Adrenergic stimulation of interleukin-1α and interleukin-6 expression in mouse brown adipocytes. FEBS Lett 411:83–86
    • (1997) FEBS Lett , vol.411 , pp. 83-86
    • Burýsek, L.1    Houstek, J.2
  • 49
    • 0035217644 scopus 로고    scopus 로고
    • β-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies
    • Mohamed-Ali V, Flower L, Sethi J et al (2001) β-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J Clin Endocrinol Metab 86:5864–5869
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5864-5869
    • Mohamed-Ali, V.1    Flower, L.2    Sethi, J.3
  • 50
    • 33748366392 scopus 로고    scopus 로고
    • Regulatory circuits controlling white versus brown adipocyte differentiation
    • Hansen JB, Kristiansen K (2006) Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J 398:153–168
    • (2006) Biochem J , vol.398 , pp. 153-168
    • Hansen, J.B.1    Kristiansen, K.2
  • 52
    • 34248372084 scopus 로고    scopus 로고
    • Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
    • Timmons JA, Wennmalm K, Larsson O et al (2007) Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci USA 104:4401–4406
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4401-4406
    • Timmons, J.A.1    Wennmalm, K.2    Larsson, O.3
  • 53
    • 50049122271 scopus 로고    scopus 로고
    • PRDM16 controls a brown fat/skeletal muscle switch
    • Seale P, Bjork B, Yang W et al (2008) PRDM16 controls a brown fat/skeletal muscle switch. Nature 454:961–967
    • (2008) Nature , vol.454 , pp. 961-967
    • Seale, P.1    Bjork, B.2    Yang, W.3
  • 54
    • 55049135857 scopus 로고    scopus 로고
    • A reservoir of brown adipocyte progenitors in human skeletal muscle
    • Crisan M, Casteilla L, Lehr L et al (2008) A reservoir of brown adipocyte progenitors in human skeletal muscle. Stem Cells 26:2425–2433
    • (2008) Stem Cells , vol.26 , pp. 2425-2433
    • Crisan, M.1    Casteilla, L.2    Lehr, L.3
  • 55
    • 33745966038 scopus 로고    scopus 로고
    • Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
    • Atit R, Sgaier SK, Mohamed OA et al (2006) Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol 296:164–176
    • (2006) Dev Biol , vol.296 , pp. 164-176
    • Atit, R.1    Sgaier, S.K.2    Mohamed, O.A.3
  • 56
    • 77953639982 scopus 로고    scopus 로고
    • Molecular aspects of thyroid hormone actions
    • Cheng SY, Leonard JL, Davis PJ (2010) Molecular aspects of thyroid hormone actions. Endocr Rev 31:139–170
    • (2010) Endocr Rev , vol.31 , pp. 139-170
    • Cheng, S.Y.1    Leonard, J.L.2    Davis, P.J.3
  • 57
    • 77954526067 scopus 로고    scopus 로고
    • Three members of the iodothyronine deiodinase family, dio1, dio2 and dio3, are expressed in spatially and temporally specific patterns during metamorphosis of the flounder, Paralichthys olivaceus
    • Itoh K, Watanabe K, Wu X et al (2010) Three members of the iodothyronine deiodinase family, dio1, dio2 and dio3, are expressed in spatially and temporally specific patterns during metamorphosis of the flounder, Paralichthys olivaceus. Zoolog Sci 27:574–580
    • (2010) Zoolog Sci , vol.27 , pp. 574-580
    • Itoh, K.1    Watanabe, K.2    Wu, X.3
  • 58
    • 0020509014 scopus 로고
    • Adrenergic activation of triiodothyronine production in brown adipose tissue
    • Silva JE, Larsen PR (1983) Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 305:712–713
    • (1983) Nature , vol.305 , pp. 712-713
    • Silva, J.E.1    Larsen, P.R.2
  • 59
    • 0003162109 scopus 로고
    • Role of the thyroid in metabolic responses to a cold environment
    • Sellers EA, You SS (1950) Role of the thyroid in metabolic responses to a cold environment. Am J Physiol 163:81–91
    • (1950) Am J Physiol , vol.163 , pp. 81-91
    • Sellers, E.A.1    You, S.S.2
  • 60
    • 0023119510 scopus 로고
    • Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue
    • Bianco AC, Silva JE (1987) Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest 79:295–300
    • (1987) J Clin Invest , vol.79 , pp. 295-300
    • Bianco, A.C.1    Silva, J.E.2
  • 61
    • 18344401514 scopus 로고    scopus 로고
    • Thyroid hormones, obesity and brown adipose tissue thermogenesis
    • Zaninovich AA (2001) Thyroid hormones, obesity and brown adipose tissue thermogenesis. Medicina (B Aires) 61:597–602
    • (2001) Medicina (B Aires) , vol.61 , pp. 597-602
    • Zaninovich, A.A.1
  • 62
    • 39449133661 scopus 로고    scopus 로고
    • Thyroid-adrenergic interactions: physiological and clinical implications
    • Silva JE, Bianco SD (2008) Thyroid-adrenergic interactions: physiological and clinical implications. Thyroid 18:157–165
    • (2008) Thyroid , vol.18 , pp. 157-165
    • Silva, J.E.1    Bianco, S.D.2
  • 63
    • 0024202118 scopus 로고
    • Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis
    • Bianco AC, Sheng XY, Silva JE (1988) Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem 263:18168–18175
    • (1988) J Biol Chem , vol.263 , pp. 18168-18175
    • Bianco, A.C.1    Sheng, X.Y.2    Silva, J.E.3
  • 64
    • 22144494186 scopus 로고    scopus 로고
    • Temperature homeostasis in transgenic mice lacking thyroid hormone receptor-alpha gene products
    • Marrif H, Schifman A, Stepanyan Z et al (2005) Temperature homeostasis in transgenic mice lacking thyroid hormone receptor-alpha gene products. Endocrinology 146:2872–2884
    • (2005) Endocrinology , vol.146 , pp. 2872-2884
    • Marrif, H.1    Schifman, A.2    Stepanyan, Z.3
  • 65
    • 79953225879 scopus 로고    scopus 로고
    • Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality
    • Castillo M, Hall JA, Correa-Medina M et al (2011) Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes 60:1082–1089
    • (2011) Diabetes , vol.60 , pp. 1082-1089
    • Castillo, M.1    Hall, J.A.2    Correa-Medina, M.3
  • 67
    • 0033791318 scopus 로고    scopus 로고
    • Cyclooxygenases: structural, cellular, and molecular biology
    • Smith WL, DeWitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145–182
    • (2000) Annu Rev Biochem , vol.69 , pp. 145-182
    • Smith, W.L.1    DeWitt, D.L.2    Garavito, R.M.3
  • 68
    • 0031689543 scopus 로고    scopus 로고
    • Cyclooxygenase in biology and disease
    • Dubois RN, Abramson SB, Crofford L et al (1998) Cyclooxygenase in biology and disease. FASEB J 12:1063–1073
    • (1998) FASEB J , vol.12 , pp. 1063-1073
    • Dubois, R.N.1    Abramson, S.B.2    Crofford, L.3
  • 69
    • 1942428953 scopus 로고    scopus 로고
    • Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia
    • Lundholm K, Daneryd P, Körner U et al (2004) Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. Int J Oncol 24:505–512
    • (2004) Int J Oncol , vol.24 , pp. 505-512
    • Lundholm, K.1    Daneryd, P.2    Körner, U.3
  • 70
    • 1342344552 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 by celecoxib reverses tumor-induced wasting
    • Davis TW, Zweifel BS, O’Neal JM et al (2004) Inhibition of cyclooxygenase-2 by celecoxib reverses tumor-induced wasting. J Pharmacol Exp Ther 308:929–934
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 929-934
    • Davis, T.W.1    Zweifel, B.S.2    O’Neal, J.M.3
  • 72
    • 77955333533 scopus 로고    scopus 로고
    • UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity
    • Madsen L, Pedersen LM, Lillefosse HH et al (2010) UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity. PLoS One 5:e11391
    • (2010) PLoS One , vol.5 , pp. e11391
    • Madsen, L.1    Pedersen, L.M.2    Lillefosse, H.H.3
  • 73
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: multifunctional regulators of vertebrate development
    • Hogan BL (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10:1580–1594
    • (1996) Genes Dev , vol.10 , pp. 1580-1594
    • Hogan, B.L.1
  • 74
    • 69149091047 scopus 로고    scopus 로고
    • BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    • Huang H, Song TJ, Li X et al (2009) BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 106:12670–12675
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12670-12675
    • Huang, H.1    Song, T.J.2    Li, X.3
  • 75
    • 33645523235 scopus 로고    scopus 로고
    • Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins
    • Jin W, Takagi T, Kanesashi SN et al (2006) Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins. Dev Cell 10:461–471
    • (2006) Dev Cell , vol.10 , pp. 461-471
    • Jin, W.1    Takagi, T.2    Kanesashi, S.N.3
  • 76
    • 84874450879 scopus 로고    scopus 로고
    • BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
    • Qian SW, Tang Y, Li X et al (2013) BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci USA 110:798–807
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 798-807
    • Qian, S.W.1    Tang, Y.2    Li, X.3
  • 77
    • 84860897594 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
    • Townsend KL, Suzuki R, Huang TL et al (2012) Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J 26:2187–2196
    • (2012) FASEB J , vol.26 , pp. 2187-2196
    • Townsend, K.L.1    Suzuki, R.2    Huang, T.L.3
  • 78
    • 84860850964 scopus 로고    scopus 로고
    • BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
    • Whittle AJ, Carobbio S, Martins L et al (2012) BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149:871–885
    • (2012) Cell , vol.149 , pp. 871-885
    • Whittle, A.J.1    Carobbio, S.2    Martins, L.3
  • 79
    • 84893711097 scopus 로고    scopus 로고
    • BMP-9 as a potent brown adipogenic inducer with anti-obesity capacity
    • Kuo MM, Kim S, Tseng CY et al (2014) BMP-9 as a potent brown adipogenic inducer with anti-obesity capacity. Biomaterials 35:3172–3179
    • (2014) Biomaterials , vol.35 , pp. 3172-3179
    • Kuo, M.M.1    Kim, S.2    Tseng, C.Y.3
  • 80
    • 0023488533 scopus 로고
    • An in vivo model for study of the angiogenic effects of basic fibroblast growth factor
    • Hayek A, Culler FL, Beattie GM et al (1987) An in vivo model for study of the angiogenic effects of basic fibroblast growth factor. Biochem Biophys Res Commun 147:876–880
    • (1987) Biochem Biophys Res Commun , vol.147 , pp. 876-880
    • Hayek, A.1    Culler, F.L.2    Beattie, G.M.3
  • 81
    • 0021946010 scopus 로고
    • Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor
    • Davidson JM, Klagsbrun M, Hill KE et al (1985) Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor. J Cell Biol 100:1219–1227
    • (1985) J Cell Biol , vol.100 , pp. 1219-1227
    • Davidson, J.M.1    Klagsbrun, M.2    Hill, K.E.3
  • 82
    • 0037089685 scopus 로고    scopus 로고
    • Requirement of fibroblast growth factor 10 in development of white adipose tissue
    • Sakaue H, Konishi M, Ogawa W et al (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev 16:908–912
    • (2002) Genes Dev , vol.16 , pp. 908-912
    • Sakaue, H.1    Konishi, M.2    Ogawa, W.3
  • 83
    • 0034697007 scopus 로고    scopus 로고
    • Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes
    • Konishi M, Mikami T, Yamasaki M et al (2000) Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. J Biol Chem 275:12119–12122
    • (2000) J Biol Chem , vol.275 , pp. 12119-12122
    • Konishi, M.1    Mikami, T.2    Yamasaki, M.3
  • 84
    • 18344394556 scopus 로고    scopus 로고
    • Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
    • Tomlinson E, Fu L, John L et al (2002) Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 143:1741–1747
    • (2002) Endocrinology , vol.143 , pp. 1741-1747
    • Tomlinson, E.1    Fu, L.2    John, L.3
  • 85
    • 79960743932 scopus 로고    scopus 로고
    • Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
    • Chartoumpekis DV, Habeos IG, Ziros PG et al (2011) Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol Med 17:736–740
    • (2011) Mol Med , vol.17 , pp. 736-740
    • Chartoumpekis, D.V.1    Habeos, I.G.2    Ziros, P.G.3
  • 87
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
    • Fisher FM, Kleiner S, Douris N et al (2012) FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26:271–281
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3
  • 88
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW et al (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829–839
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3
  • 89
    • 5344252327 scopus 로고    scopus 로고
    • Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1 alpha null mice
    • Lin J, Wu PH, Tarr PT et al (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1 alpha null mice. Cell 119:121–135
    • (2004) Cell , vol.119 , pp. 121-135
    • Lin, J.1    Wu, P.H.2    Tarr, P.T.3
  • 90
    • 33646124709 scopus 로고    scopus 로고
    • Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
    • Uldry M, Yang W, St-Pierre J et al (2006) Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab 3:333–341
    • (2006) Cell Metab , vol.3 , pp. 333-341
    • Uldry, M.1    Yang, W.2    St-Pierre, J.3
  • 91
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1 alpha expression protects from sarcopenia and metabolic disease during aging
    • Wenz T, Rossi SG, Rotundo RL et al (2009) Increased muscle PGC-1 alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 106:20405–20410
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3
  • 92
    • 0034332196 scopus 로고    scopus 로고
    • A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1_EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells
    • Mochizuki N, Shimizu S, Nagasawa T et al (2000) A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1_EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood 96:3209–3214
    • (2000) Blood , vol.96 , pp. 3209-3214
    • Mochizuki, N.1    Shimizu, S.2    Nagasawa, T.3
  • 93
    • 69349088117 scopus 로고    scopus 로고
    • Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
    • Kajimura S, Seale P, Kubota K et al (2009) Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 460:1154–1158
    • (2009) Nature , vol.460 , pp. 1154-1158
    • Kajimura, S.1    Seale, P.2    Kubota, K.3
  • 94
    • 44149120984 scopus 로고    scopus 로고
    • Molecular determinants of brown adipocyte formation and function
    • Farmer SR (2008) Molecular determinants of brown adipocyte formation and function. Genes Dev 22:1269–1275
    • (2008) Genes Dev , vol.22 , pp. 1269-1275
    • Farmer, S.R.1
  • 95
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9:102–114
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 96
    • 79960984113 scopus 로고    scopus 로고
    • Mir193b-365 is essential for brown fat differentiation
    • Sun L, Xie H, Mori MA et al (2011) Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol 13:958–965
    • (2011) Nat Cell Biol , vol.13 , pp. 958-965
    • Sun, L.1    Xie, H.2    Mori, M.A.3
  • 97
    • 84880812042 scopus 로고    scopus 로고
    • MiR-133a Regulates adipocyte browning in vivo
    • Liu W, Bi P, Shan T et al (2013) MiR-133a Regulates adipocyte browning in vivo. PLoS Genet 9:1–11
    • (2013) PLoS Genet , vol.9 , pp. 1-11
    • Liu, W.1    Bi, P.2    Shan, T.3
  • 98
    • 84892678138 scopus 로고    scopus 로고
    • MiR-27 orchestrates the transcriptional regulation of brown adipogenesis
    • Sun L, Trajkovski M (2014) MiR-27 orchestrates the transcriptional regulation of brown adipogenesis. Metabolism 63:272–282
    • (2014) Metabolism , vol.63 , pp. 272-282
    • Sun, L.1    Trajkovski, M.2
  • 99
    • 84860009214 scopus 로고    scopus 로고
    • Essential role for miR-196a in brown adipogenesis of white fat progenitor cells
    • Mori M, Nakagami H, Rodriguez-Araujo G et al (2012) Essential role for miR-196a in brown adipogenesis of white fat progenitor cells. PLoS Biol 10:e1001314
    • (2012) PLoS Biol , vol.10 , pp. e1001314
    • Mori, M.1    Nakagami, H.2    Rodriguez-Araujo, G.3
  • 100
    • 84877747920 scopus 로고    scopus 로고
    • miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit
    • Chen Y, Siegel F, Kipschull S et al (2013) miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun 4:1–13
    • (2013) Nat Commun , vol.4 , pp. 1-13
    • Chen, Y.1    Siegel, F.2    Kipschull, S.3
  • 101
    • 84901423103 scopus 로고    scopus 로고
    • MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes
    • Karbiener M, Pisani DF, Frontini A et al (2013) MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes. Stem Cells. doi:10.1002/stem.1603
    • (2013) Stem Cells
    • Karbiener, M.1    Pisani, D.F.2    Frontini, A.3
  • 102
    • 0021319695 scopus 로고
    • Brown adipose tissue in the parametrial fat pad of the mouse
    • Young P, Arch JR, Ashwell M (1984) Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett 167:10–14
    • (1984) FEBS Lett , vol.167 , pp. 10-14
    • Young, P.1    Arch, J.R.2    Ashwell, M.3
  • 103
    • 0027051199 scopus 로고
    • Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization
    • Cousin B, Cinti S, Morroni M et al (1992) Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 103:931–942
    • (1992) J Cell Sci , vol.103 , pp. 931-942
    • Cousin, B.1    Cinti, S.2    Morroni, M.3
  • 104
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J, Boström P, Sparks LM et al (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150:366–376
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1    Boström, P.2    Sparks, L.M.3
  • 105
    • 84859410604 scopus 로고    scopus 로고
    • The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
    • Vitali A, Murano I, Zingaretti MC et al (2012) The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J Lipid Res 53:619–629
    • (2012) J Lipid Res , vol.53 , pp. 619-629
    • Vitali, A.1    Murano, I.2    Zingaretti, M.C.3
  • 106
    • 84887502374 scopus 로고    scopus 로고
    • Tracking adipogenesis during white adipose tissue development, expansion and regeneration
    • Wang QA, Tao C, Gupta RK et al (2013) Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med 19:1338–1344
    • (2013) Nat Med , vol.19 , pp. 1338-1344
    • Wang, Q.A.1    Tao, C.2    Gupta, R.K.3
  • 109
    • 84877331455 scopus 로고    scopus 로고
    • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    • Cypess AM, White AP, Vernochet C et al (2013) Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 19:635–639
    • (2013) Nat Med , vol.19 , pp. 635-639
    • Cypess, A.M.1    White, A.P.2    Vernochet, C.3
  • 110
    • 84877340732 scopus 로고    scopus 로고
    • Evidence for two types of brown adipose tissue in humans
    • Lidell ME, Betz MJ, Dahlqvist Leinhard O et al (2013) Evidence for two types of brown adipose tissue in humans. Nat Med 19:631–634
    • (2013) Nat Med , vol.19 , pp. 631-634
    • Lidell, M.E.1    Betz, M.J.2    Dahlqvist Leinhard, O.3
  • 111
    • 0028141177 scopus 로고
    • The uncoupling protein thermogenin during acclimation: indications for pretranslational control
    • Jacobsson A, Mühleisen M, Cannon B et al (1994) The uncoupling protein thermogenin during acclimation: indications for pretranslational control. Am J Physiol 267:R999–R1007
    • (1994) Am J Physiol , vol.267 , pp. R999-R1007
    • Jacobsson, A.1    Mühleisen, M.2    Cannon, B.3
  • 112
    • 0000143140 scopus 로고
    • Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia
    • Bukowiecki L, Collet AJ, Follea N et al (1982) Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia. Am J Physiol 242:E353–E359
    • (1982) Am J Physiol , vol.242 , pp. E353-E359
    • Bukowiecki, L.1    Collet, A.J.2    Follea, N.3
  • 114
    • 84881260642 scopus 로고    scopus 로고
    • Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
    • van der Lans AA, Hoeks J, Brans B et al (2013) Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest 123:3395–3403
    • (2013) J Clin Invest , vol.123 , pp. 3395-3403
    • van der Lans, A.A.1    Hoeks, J.2    Brans, B.3
  • 115
    • 80155201442 scopus 로고    scopus 로고
    • Central circuitries for body temperature regulation and fever
    • Nakamura K (2011) Central circuitries for body temperature regulation and fever. Am J Physiol Regul Integr Comp Physiol 301:R1207–R1228
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301 , pp. R1207-R1228
    • Nakamura, K.1
  • 116
    • 33746073072 scopus 로고    scopus 로고
    • Impact of animal handling on the results of 18F-FDG PET studies in mice
    • Fueger BJ, Czernin J, Hildebrandt I et al (2006) Impact of animal handling on the results of 18F-FDG PET studies in mice. J Nucl Med 47:999–1006
    • (2006) J Nucl Med , vol.47 , pp. 999-1006
    • Fueger, B.J.1    Czernin, J.2    Hildebrandt, I.3
  • 117
    • 0026408143 scopus 로고
    • Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue
    • Dulloo AG, Seydoux J, Girardier L (1991) Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. Int J Obes 15:317–326
    • (1991) Int J Obes , vol.15 , pp. 317-326
    • Dulloo, A.G.1    Seydoux, J.2    Girardier, L.3
  • 118
    • 84862515329 scopus 로고    scopus 로고
    • Cold but not sympathomimetics activates human brown adipose tissue in vivo
    • Cypess AM, Chen YC, Sze C et al (2012) Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci USA 109:10001–10005
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 10001-10005
    • Cypess, A.M.1    Chen, Y.C.2    Sze, C.3
  • 119
    • 84868213635 scopus 로고    scopus 로고
    • Brown adipose tissue and the regulation of nonshivering thermogenesis
    • van Marken Lichtenbelt W (2012) Brown adipose tissue and the regulation of nonshivering thermogenesis. Curr Opin Clin Nutr Metab Care 15:547–552
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 547-552
    • van Marken Lichtenbelt, W.1
  • 120
    • 0029437575 scopus 로고
    • Effects of red-pepper diet on the energy metabolism in men
    • Yoshioka M, Lim K, Kikuzato S et al (1995) Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol (Tokyo) 41:647–656
    • (1995) J Nutr Sci Vitaminol (Tokyo) , vol.41 , pp. 647-656
    • Yoshioka, M.1    Lim, K.2    Kikuzato, S.3
  • 121
    • 0023008170 scopus 로고
    • Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization
    • Kawada T, Watanabe T, Takaishi T et al (1986) Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc Soc Exp Biol Med 183:250–256
    • (1986) Proc Soc Exp Biol Med , vol.183 , pp. 250-256
    • Kawada, T.1    Watanabe, T.2    Takaishi, T.3
  • 122
    • 77952243631 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure
    • Wang C, Bomberg E, Billington CJ et al (2010) Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure. Brain Res 1336:66–77
    • (2010) Brain Res , vol.1336 , pp. 66-77
    • Wang, C.1    Bomberg, E.2    Billington, C.J.3
  • 123
    • 80053928150 scopus 로고    scopus 로고
    • Orexin is required for brown adipose tissue development, differentiation, and function
    • Sellayah D, Bharaj P, Sikder D (2011) Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab 14:478–490
    • (2011) Cell Metab , vol.14 , pp. 478-490
    • Sellayah, D.1    Bharaj, P.2    Sikder, D.3
  • 124
    • 0024461962 scopus 로고
    • The protein kinase domain of the ANP receptor is required for signaling
    • Chinkers M, Garbers DL (1989) The protein kinase domain of the ANP receptor is required for signaling. Science 245:1392–1394
    • (1989) Science , vol.245 , pp. 1392-1394
    • Chinkers, M.1    Garbers, D.L.2
  • 125
    • 84863229962 scopus 로고    scopus 로고
    • Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    • Bordicchia M, Liu D, Amri EZ et al (2012) Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest 122:1022–1036
    • (2012) J Clin Invest , vol.122 , pp. 1022-1036
    • Bordicchia, M.1    Liu, D.2    Amri, E.Z.3
  • 126
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Boström P, Wu J, Jedrychowski MP et al (2012) A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–468
    • (2012) Nature , vol.481 , pp. 463-468
    • Boström, P.1    Wu, J.2    Jedrychowski, M.P.3
  • 128
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • Tseng YH, Cypess AM, Kahn CR (2010) Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 9:465–482
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 465-482
    • Tseng, Y.H.1    Cypess, A.M.2    Kahn, C.R.3
  • 129
    • 34547631960 scopus 로고    scopus 로고
    • Unexpected evidence for active brown adipose tissue in adult humans
    • Nedergaard J, Bengtsson T, Cannon B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293:E444–E452
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E444-E452
    • Nedergaard, J.1    Bengtsson, T.2    Cannon, B.3
  • 130
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen KA, Lidell ME, Orava J et al (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518–1525
    • (2009) N Engl J Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 131
    • 0015332110 scopus 로고
    • The distribution of brown adipose tissue in the human
    • Heaton JM (1972) The distribution of brown adipose tissue in the human. J Anat 112:35–39
    • (1972) J Anat , vol.112 , pp. 35-39
    • Heaton, J.M.1
  • 132
    • 77952623888 scopus 로고    scopus 로고
    • The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte trans differentiation
    • Barbatelli G, Murano I, Madsen L et al (2010) The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte trans differentiation. Am J Physiol Endocrinol Metab 298:E1244–E1253
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E1244-E1253
    • Barbatelli, G.1    Murano, I.2    Madsen, L.3
  • 133
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic N, Walden TB, Shabalina IG et al (2010) Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 285:7153–7164
    • (2010) J Biol Chem , vol.285 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3
  • 134
    • 1342323625 scopus 로고    scopus 로고
    • Beta-adrenergic receptors and regulation of energy expenditure: a family affair
    • Robidoux J, Martin TL, Collins S (2004) Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol 44:297–323
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 297-323
    • Robidoux, J.1    Martin, T.L.2    Collins, S.3
  • 135
    • 79960480409 scopus 로고    scopus 로고
    • The implication of brown adipose tissue for humans
    • Ravussin E, Galgani JE (2011) The implication of brown adipose tissue for humans. Annu Rev Nutr 31:33–47
    • (2011) Annu Rev Nutr , vol.31 , pp. 33-47
    • Ravussin, E.1    Galgani, J.E.2
  • 136
    • 64349121056 scopus 로고    scopus 로고
    • Transcriptional control of brown adipocyte development and physiological function-of mice and men
    • Seale P, Kajimura S, Spiegelman BM (2009) Transcriptional control of brown adipocyte development and physiological function-of mice and men. Genes Dev 23:788–797
    • (2009) Genes Dev , vol.23 , pp. 788-797
    • Seale, P.1    Kajimura, S.2    Spiegelman, B.M.3
  • 137
    • 0037066575 scopus 로고    scopus 로고
    • Beta(3)-adrenoceptor agonists: potential, pitfalls and progress
    • Arch JR (2002) Beta(3)-adrenoceptor agonists: potential, pitfalls and progress. Eur J Pharmacol 440:99–107
    • (2002) Eur J Pharmacol , vol.440 , pp. 99-107
    • Arch, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.