A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells

Blood

Volumn 96, Issue 9, 2000, Pages 3209-3214

  Mochizuki, N ^a   Shimizu, S ^a   Nagasawa, T ^a   Tanaka, H ^a   Taniwaki, M ^a   Yokota, J ^a   Morishita, K ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GENE PRODUCT; NUCLEOTIDE; PROTEIN EVI1; PROTEIN MDS1; PROTEIN MEL1; RIBOPHORIN I; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; AMINO ACID SEQUENCE; ARTICLE; CELL LINE; CHROMOSOME 1P; CONTROLLED STUDY; GENE EXPRESSION; GENE ISOLATION; GENE MAPPING; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMOGENESIS; MALIGNANT TRANSFORMATION; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROTEIN DOMAIN; RECIPROCAL CHROMOSOME TRANSLOCATION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

EID: 0034332196     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.9.3209.h8003209_3209_3214     Document Type: Article

References (28)

1. A break-point map of recurrent chromosomal rearrangements in human neoplasia
2. Abnormalities of 3q21 and 3q26 in myeloid malignancy: A United Kingdom Cancer Cytogenetic Group Study
3. 3q21 and 3q26 cytogenetic abnormalities in acute myeloblastic leukemia: Biological and clinical features
4. Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26
5. Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26)
6. Identification of translocational breakpoints within the intron region before the last coding exon (exon 12) of the EVI1 gene in two cases of CML-BC with inv(3)(q21q26)
7. A new translocation, t(1;3)(p36; q21), in myelodysplastic disorders
8. t(1;3)(p36;q21) in acute nonlymphocytic leukemia: A new cytogenetic-clinicopathologic association
9. Diagnostic and prognostic significance of t(1;3)(p36; q21) in the disorders of hematopoiesis
10. Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3) (p36;q21)
11. Characterization of a factor-dependent acute leukemia cell line with translocation(3;3)(q21;q26)
12. Establishment of an undifferentiated leukemia cell line (Kasumi-3) with t(3;7)(q27;q22) and activation of the EVI1 gene
13. Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas
14. Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes
15. Acute myelogenous leukemia: A human cell line responsive to colony-stimulating activity
16. Establishment of a myeloid leukaemia cell line (Kasumi-4) with t(9;22;11)(q34;q11;q13), inv(3)(q21q26) and the EVI1 gene activation from a patient with chronic myelogenous leukaemia in blast crisis
17. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia
18. Tumor-specific rearrangements of the immunoglobulin heavy-chain gene in B-cell non-Hodgkin's lymphoma detected by in situ hybridization
19. Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method
20. The retinoblastoma protein binds to RIZ, a zinc finger protein that shares an epitope with the adenovirus E1A protein
21. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family
22. Cloning and characterization of mCtBP2, a co-repressor that associated with basic Kruppel-like factor and other mammalian transcriptional regulators
23. Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site in leukemia
24. Functional characterization of the cis-regulatory elements of the rat ribophorin I gene
25. The PR domain of the Rb-binding zinc finger gene RIZ1 is a protein-binding interface and is related to the SET domain functioning in chromatin mediated gene expression
26. The leukemia-associated gene MDS1/EVI1 is a new type of GATA-binding transactivator
27. MDS1/EVI1 enhances TGF-β1 signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1