Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups

European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 528-541

  Bhansali, Pravin ^a   Hanigan, Christin L ^b   Perera, Lalith ^c   Casero, Robert A ^b   Tillekeratne, L M Viranga ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Antiproliferation; Antitumor agents; Biological activity; Histone deacetylase inhibitors; Molecular modeling

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; HISTONE H3; DEPSIPEPTIDE; HISTONE DEACETYLASE; LARGAZOLE; THIAZOLE DERIVATIVE;

ALDOL REACTION; ARTICLE; CELL PROLIFERATION; COLORECTAL CANCER CELL LINE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; EPIMER; HISTONE ACETYLATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MTS ASSAY; SURFACE PROPERTY; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HCT116 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HCT116 CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84907811029     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.009     Document Type: Article

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