Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4626-4634

  Whitehead, Lewis ^a   Dobler, Markus R ^a   Radetich, Branko ^a   Zhu, Yanyi ^a   Atadja, Peter W ^a   Claiborne, Tavina ^a   Grob, Jonathan E ^a   McRiner, Andrew ^a   Pancost, Margaret R ^a   Patnaik, Anup ^a   Shao, Wenlin ^a   Shultz, Michael ^a   Tichkule, Ritesh ^a   Tommasi, Ruben A ^a   Vash, Brian ^a   Wang, Ping ^a   Stams, Travis ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Acetate release hypothesis; Histone deacetylase; Metal binding; Selectivity; X ray crystallography

Indexed keywords

ACETIC ACID; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; PANOBINOSTAT; TRICHOSTATIN A; VORINOSTAT;

ANEMIA; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CRYSTAL STRUCTURE; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; LIGAND BINDING; METABOLIC DISORDER; METAL BINDING; MOLECULAR MODEL; NAUSEA; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; T CELL LYMPHOMA; THROMBOCYTOPENIA; X RAY CRYSTALLOGRAPHY;

ACETIC ACID; AMINO ACIDS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MODELS, MOLECULAR; PROTEIN ISOFORMS;

EID: 79960561626     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.030     Document Type: Article

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