Interplay between steroid signalling and microRNAs: Implications for hormone-dependent cancers

Endocrine-Related Cancer

Volumn 21, Issue 5, 2014, Pages R409-R429

  Fletcher, Claire E ^a   Dart, D Alwyn ^a,b   Bevan, Charlotte L ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Androgen; Breast; Dicer; Drosha; Estrogen; Microprocessor; MicroRNA; Prostate

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; HORMONE; MICRORNA; STEROID;

ANIMAL; GENETICS; HUMAN; METABOLISM; NEOPLASM; SIGNAL TRANSDUCTION;

ANIMALS; ESTROGEN RECEPTOR ALPHA; HORMONES; HUMANS; MICRORNAS; NEOPLASMS, HORMONE-DEPENDENT; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; STEROIDS;

EID: 84907532727     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-14-0208     Document Type: Article

References (163)

1. Adams BD, Furneaux H & White BA 2007 The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-α (ERα) and represses ERα messenger RNA and protein expression in breast cancer cell lines. Molecular Endocrinology 21 1132-1147. (doi:10.1210/me.2007-0022)
2. Adams BD, Cowee DM & White BA 2009 The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-α (ERα) signaling and a luminal phenotype in MCF-7 breast cancer cells. Molecular Endocrinology 23 1215-1230. (doi:10.1210/me.2009-0062)
3. Akman BH, Can T & Erson-Bensan AE 2012 Estrogen-induced upregulation and 3′-UTR shortening of CDC6. Nucleic Acids Research 40 10679-10688. (doi:10.1093/nar/gks855)
4. Ambs S, Prueitt RL, Yi M, Hudson RS, Howe TM, Petrocca F, Wallace TA, Liu CG, Volinia S, Calin GA et al. 2008 Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Research 68 6162-6170. (doi:10.1158/0008-5472.CAN-08-0144)
5. Bartel DP 2009 MicroRNAs: target recognition and regulatory functions. Cell 136 215-233. (doi:10.1016/j.cell.2009.01.002)
6. Bhat-Nakshatri P, Wang G, Appaiah H, Luktuke N, Carroll JS, Geistlinger TR, Brown M, Badve S, Liu Y & Nakshatri H 2008 AKT alters genome-wide estrogen receptor α binding and impacts estrogen signaling in breast cancer. Molecular and Cellular Biology 28 7487-7503. (doi:10.1128/MCB.00799-08).
7. Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, Hammond S, Srour EF, Liu Y et al. 2009 Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Research 37 4850-4861. (doi:10.1093/nar/gkp500)
8. Blenkiron C, Goldstein L, Thorne N, Spiteri I, Chin S-F, Dunning M, Barbosa-Morais N, Teschendorff A, Green A, Ellis I et al. 2007 MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biology 8 R214. (doi:10.1186/gb-2007-8-10-r214)
9. Bonci D, Coppola V, Musumeci M, Addario A, Giuffrida R, Memeo L, D'Urso L, Pagliuca A, Biffoni M, Labbaye C et al. 2008 The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nature Medicine 14 1271-1277. (doi:10.1038/nm.1880)
10. Brooke GN, Culley RL, Dart DA, Mann DJ, Gaughan L, McCracken SR, Robson CN, Spencer-Dene B, Gamble SC, Powell SM et al. 2011 FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth. Cancer Research 71 914-924. (doi:10.1158/0008-5472.CAN-10-0874)
11. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M et al. 2004 Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. PNAS 101 2999-3004. (doi:10.1073/pnas.0307323101)
12. Cao P, Deng Z, Wan M, Huang W, Cramer S, Xu J, Lei M & Sui G 2010 MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta. Molecular Cancer 9 108.
13. Castellano L, Giamas G, Jacob J, Coombes RC, Lucchesi W, Thiruchelvam P, Barton G, Jiao LR, Wait R, Waxman J et al. 2009 The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response. PNAS 106 15732-15737. (doi:10.1073/pnas.0906947106)
14. Cheng C, Fu X, Alves P & Gerstein M 2009 mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer. Genome Biology 10 R90. (doi:10.1186/gb-2009-10-9-r90)
15. Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol RW & Dhir R 2006 Up-regulation of dicer, a component of the microRNA machinery, in prostate adenocarcinoma. American Journal of Pathology 169 1812-1820. (doi:10.2353/ajpath.2006.060480)
16. Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW & Dacic S 2007 Overexpression of dicer in precursor lesions of lung adenocarcinoma. Cancer Research 67 2345-2350. (doi:10.1158/0008-5472.CAN-06-3533)
17. Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M et al. 2010 Estrogen receptor a controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. American Journal of Pathology 176 2113-2130. (doi:10.2353/ajpath.2010.090837)
18. Clark EL, Coulson A, Dalgliesh C, Rajan P, Nicol SM, Fleming S, Heer R, Gaughan L, Leung HY, Elliott DJ et al. 2008 The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer. Cancer Research 68 7938-7946. (doi:10.1158/0008-5472.CAN-08-0932)
19. Cochrane D, Cittelly D, Howe E, Spoelstra N, McKinsey E, LaPara K, Elias A, Yee D & Richer J 2010 MicroRNAs link estrogen receptor a status and Dicer levels in breast cancer. Hormones & Cancer 1 306-319. (doi:10.1007/s12672-010-0043-5)
20. Cohen A, Shmoish M, Levi L, Cheruti U, Levavi-Sivan B & Lubzens E 2008 Alterations in micro-ribonucleic acid expression profiles reveal a novel pathway for estrogen regulation. Endocrinology 149 1687-1696. (doi:10.1210/en.2007-0969)
21. Craft N, Shostak Y, Carey M & Sawyers CL 1999 A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nature Medicine 5 280-285. (doi:10.1038/6495)
22. Dai R, Phillips RA, Zhang Y, Khan D, Crasta O & Ahmed SA 2008 Suppression of LPS-induced interferon-γ and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood 112 4591-4597. (doi:10.1182/blood-2008-04-152488)
23. Dai A, Sun H, Fang T, Zhang Q, Wu S, Jiang Y, Ding L, Yan G & Hu Y 2013 MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2. FEBS Letters 587 2474-2482. (doi:10.1016/j.febslet.2013.06.023)
24. Dart DA, Brooke GN, Sita-Lumsden A, Waxman J & Bevan CL 2011 Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens. Oncogene 31 4588-4598. (doi:10.1038/onc.2011.591)
25. Davis BN, Hilyard AC, Lagna G & Hata A 2008 SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61. (doi:10.1038/nature07086)
26. Di Leva G, Gasparini P, Piovan C, Ngankeu A, Garofalo M, Taccioli C, Iorio MV, Li M, Volinia S, Alder H et al. 2010 MicroRNA cluster 221-222 and estrogen receptor α interactions in breast cancer. Journal of the National Cancer Institute 102 706-721. (doi:10.1093/jnci/djq102)
27. Di Leva G, Piovan C, Gasparini P, Ngankeu A, Taccioli C, Briskin D, Cheung DG, Bolon B, Anderlucci L, Alder H et al. 2013 Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLoS Genetics 9 e1003311. (doi:10.1371/journal.pgen.1003311)
28. Epis MR, Giles KM, Barker A, Kendrick TS & Leedman PJ 2009 miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancer. Journal of Biological Chemistry 284 24696-24704. (doi:10.1074/jbc.M109.030098)
29. Faber C, Horst D, Hlubek F & Kirchner T 2011 Overexpression of Dicer predicts poor survival in colorectal cancer. European Journal of Cancer 47 1414-1419. (doi:10.1016/j.ejca.2011.01.006)
30. Ferraro L, Ravo M, Nassa G, Tarallo R, Filippo M, Giurato G, Cirillo F, Stellato C, Silvestro S, Cantarella C et al. 2012 Effects of oestrogen on microRNA expression in hormone-responsive breast cancer cells. Hormones & Cancer 3 65-78. (doi:10.1007/s12672-012-0102-1)
31. Fletcher CE, Dart DA, Sita-Lumsden A, Cheng H, Rennie PS & Bevan CL 2012 Androgen-regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer. Human Molecular Genetics 21 3112-3127. (doi:10.1093/hmg/dds139)
32. Foley N, Bray I, Watters K, Das S, Bryan K, Bernas T, Prehn J & Stallings R 2011 MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2. Cell Death and Differentiation 18 1089-1098. (doi:10.1038/cdd.2010.172)
33. Fukuchi J, Hiipakka RA, Kokontis JM, Hsu S, Ko AL, Fitzgerald ML & Liao S 2004 Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells. Cancer Research 64 7682-7685. (doi:10.1158/0008-5472.CAN-04-2647)
34. Fukuda T, Yamagata K, Fujiyama S, Matsumoto T, Koshida I, Yoshimura K, Mihara M, Naitou M, Endoh H, Nakamura T et al. 2007 DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nature Cell Biology 9 604-611. (doi:10.1038/ncb1577)
35. Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M & Chen CY 2004 A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Molecular Cell 14 571-583. (doi:10.1016/j.molcel.2004.05.002)
36. Gong A-Y, Eischeid A, Xiao J, Zhao J, Chen D, Wang Z-Y, Young C & Chen X-M 2012 miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells. BMC Cancer 12 492.
37. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N & Shiekhattar R 2004 The Microprocessor complex mediates the genesis of microRNAs. Nature 432 235-240. (doi:10.1038/nature03120)
38. Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP & Bartel DP 2007 MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Molecular Cell 27 91-105. (doi:10.1016/j.molcel.2007.06.017)
39. Guil S & Caceres JF 2007 The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nature Structural & Molecular Biology 14 591-596. (doi:10.1038/nsmb1250)
40. Hagman Z, Haflidadottir BS, Ceder JA, Larne O, Bjartell A, Lilja H, Edsjo A & Ceder Y 2013 miR-205 negatively regulates the androgen receptor and is associated with adverse outcome of prostate cancer patients. British Journal of Cancer 108 1668-1676. (doi:10.1038/bjc.2013.131)
41. Hah N, Danko CG, Core L, Waterfall JJ, Siepel A, Lis JT & Kraus WL 2011 A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells. Cell 145 622-634. (doi:10.1016/j.cell.2011.03.042)
42. Haile S, Lal A, Myung JK & Sadar MD 2011 FUS/TLS is a co-activator of androgen receptor in prostate cancer cells. PLoS ONE 6 e24197. (doi:10.1371/journal.pone.0024197)
43. Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, Yeom KH, Yang WY, Haussler D, Blelloch R & Kim VN 2009 Posttranscriptional cross-regulation between drosha and DGCR8. Cell 136 75-84. (doi:10.1016/j.cell.2008.10.053)
44. He B, Feng Q, Mukherjee A, Lonard DM, DeMayo FJ, Katzenellenbogen BS, Lydon JP & O'Malley BW 2008 A repressive role for prohibitin in estrogen signaling. Molecular Endocrinology 22 344-360. (doi:10.1210/me.2007-0400)
45. Hossain A, Kuo MT & Saunders GF 2006 Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Molecular and Cellular Biology 26 8191-8201. (doi:10.1128/MCB.00242-06)
46. Hu Z, Shen W-J, Cortez Y, Tang X, Liu L-F, Kraemer FB & Azhar S 2013 Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland. PLoS ONE 8 e78040.
47. Hube F, Guo J, Chooniedass-Kothari S, Cooper C, Hamedani M, Dibrov A, Blanchard A, Wang X, Deng G, Myal Y et al. 2006 Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines. DNA and Cell Biology 25 418-428. (doi:10.1089/dna.2006.25.418)
48. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M et al. 2005 MicroRNA gene expression deregulation in human breast cancer. Cancer Research 65 7065-7070. (doi:10.1158/0008-5472.CAN-05-1783)
49. Jalava SE, Urbanucci A, Latonen L, Waltering KK, Sahu B, Janne OA, Seppala J, Lahdesmaki H, Tammela TL & Visakorpi T 2012 Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer. Oncogene 31 4460-4471. (doi:10.1038/onc.2011.624)
50. Jiang J, Lee EJ, Gusev Y & Schmittgen TD 2005 Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Research 33 5394-5403. (doi:10.1093/nar/gki863)
51. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D & Slack FJ 2005 RAS is regulated by the let-7 microRNA family. Cell 120 635-647. (doi:10.1016/j.cell.2005.01.014)
52. Kanda I, Nishimura N, Nakatsuji H, Yamamura R, Nakanishi H & Sasaki T 2007 Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering. Oncogene 27 1687-1695. (doi:10.1038/sj.onc.1210812)
53. Karube Y, Tanaka H, Osada H, Tomida S, Tatematsu Y, Yanagisawa K, Yatabe Y, Takamizawa J, Miyoshi S, Mitsudomi T et al. 2005 Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Science 96 111-115. (doi:10.1111/j.1349-7006.2005.00015.x)
54. Kashat M, Azzouz L, Sarkar S, Kong D, Li Y & Sarkar F 2013 Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness. American Journal of Translational Research 4 432-442.
55. Katchy A, Edvardsson K, Aydogdu E & Williams C 2012 Estradiol-activated estrogen receptor α does not regulate mature microRNAs in T47D breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology 128 145-153. (doi:10.1016/j.jsbmb.2011.10.008)
56. Kawahara Y & Mieda-Sato A 2012 TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. PNAS 109 3347-3352. (doi:10.1073/pnas.1112427109)
57. Kawai S & Amano A 2012 BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex. Journal of Cell Biology 197 201-208. (doi:10.1083/jcb.201110008)
58. Kawamata T, Seitz H & Tomari Y 2009 Structural determinants of miRNAs for RISC loading and slicer-independent unwinding. Nature Structural & Molecular Biology 16 953-960. (doi:10.1038/nsmb.1630)
59. Kim T-D, Lee SU, Yun S, Sun H-N, Lee SH, Kim JW, Kim HM, Park S-K, Lee CW, Yoon SR et al. 2011 Human microRNA-27a∗ targets Prf1 and GzmB expression to regulate NK cell cytotoxicity. Blood 118 5476-5486. (doi:10.1182/blood-2011-04-347526)
60. Klinge C 2009 Estrogen regulation of microRNA expression. Current Genomics 10 169-183. (doi:10.2174/138920209788185289)
61. Kondo N, Toyama T, Sugiura H, Fujii Y & Yamashita H 2008 miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer. Cancer research 68 5004-5008. (doi:10.1158/0008-5472.CAN-08-0180)
62. Kovalchuk O, Tryndyak V, Montgomery B, Boyko A, Kutanzi K, Zemp F, Warbritton A, Latendresse J, Kovalchuk I, Beland F et al. 2007 Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression. Cell Cycle 6 2010-2018. (doi:10.4161/cc.6.16.4549)
63. Krichevsky AM & Gabriely G 2009 miR-21: a small multi-faceted RNA. Journal of Cellular and Molecular Medicine 13 39-53. (doi:10.1111/j.1582-4934.2008.00556.x)
64. Kumar MS, Lu J, Mercer KL, Golub TR & Jacks T 2007 Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genetics 39 673-677. (doi:10.1038/ng2003)
65. Kumarswamy R, Volkmann I & Thum T 2011 Regulation and function of miRNA-21 in health and disease. RNA Biology 8 706-713. (doi:10.4161/rna.8.5.16154)
66. Lagos-Quintana M, Rauhut R, Lendeckel W & Tuschl T 2001 Identification of novel genes coding for small expressed RNAs. Science 294 853-858. (doi:10.1126/science.1064921)
67. Landthaler M, Yalcin A & Tuschl T 2004 The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Current Biology 14 2162-2167. (doi:10.1016/j.cub.2004.11.001)
68. Lanz RB, Razani B, Goldberg AD & O'Malley BW2002 Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA). PNAS 99 16081-16086. (doi:10.1073/pnas.192571399)
69. Lau NC, Lim LP, Weinstein EG & Bartel DP 2001 An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294 858-862. (doi:10.1126/science.1065062)
70. Lee RC & Ambros V 2001 An extensive class of small RNAs in Caenorhabditis elegans. Science 294 862-864. (doi:10.1126/science.1065329)
71. Lee RC, Feinbaum RL & Ambros V 1993 The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75 843-854. (doi:10.1016/0092-8674(93)90529-Y)
72. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Radmark O, Kim S et al. 2003 The nuclear RNase III Drosha initiates microRNA processing. Nature 425 415-419. (doi:10.1038/nature01957)
73. Leivonen SK, Makela R, Ostling P, Kohonen P, Haapa-Paananen S, Kleivi K, Enerly E, Aakula A, Hellstrom K, Sahlberg N et al. 2009 Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene 28 3926-3936. (doi:10.1038/onc.2009.241)
74. Levin ER 2011 Minireview: Extranuclear steroid receptors: roles in modulation of cell functions. Molecular Endocrinology 25 377-384. (doi:10.1210/me.2010-0284)
75. Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J & Safe S 2010 MicroRNA-27a indirectly regulates estrogen receptor α expression and hormone responsiveness in MCF-7 breast cancer cells. Endocrinology 151 2462-2473. (doi:10.1210/en.2009-1150)
76. Lin HK, Hu YC, Lee DK & Chang C 2004 Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Molecular Endocrinology 18 2409-2423. (doi:10.1210/me.2004-0117)
77. Lin CY, Vega VB, Thomsen JS, Zhang T, Kong SL, Xie M, Chiu KP, Lipovich L, Barnett DH, Stossi F et al. 2007 Whole-genome cartography of estrogen receptor α binding sites. PLoS Genetics 3 e87. (doi:10.1371/journal.Pgen.0030087)
78. Macias S, Michlewski G & Cáceres JF 2009 Hormonal regulation of microRNA biogenesis. Molecular Cell 36 172-173. (doi:10.1016/j.Molcel.2009.10.006)
79. Mah S, Buske C, Humphries R & Kuchenbauer F 2010 miRNA∗: a passenger stranded in RNA-induced silencing complex? Critical Reviews in Eukaryotic Gene Expression 20 141-148. (doi:10.1615/CritRevEukar-GeneExpr.v20.i2.40)
80. Maillot G, Lacroix-Triki M, Pierredon S, Gratadou L, Schmidt S, Bénès V, Roché H, Dalenc F, Auboeuf D, Millevoi S et al. 2009 Widespread estrogendependent repression ofmicroRNAs involved in breast tumor cell growth. Cancer Research 69 8332-8340. (doi:10.1158/0008-5472.CAN-09-2206)
81. Massie CE, Adryan B, Barbosa-Morais NL, Lynch AG, Tran MG, Neal DE & Mills IG 2007 New androgen receptor genomic targets show an interaction with the ETS1 transcription factor. EMBO Reports 8 871-878.
82. Masuda M, Miki Y, Hata S, Takagi K, Sakurai M, Ono K, Suzuki K, Yang Y, Abe E, Hirakawa H et al. 2012 An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma. Journal of Translational Medicine 10 S2. (doi:10.1186/1479-5876-10-S1-S2)
83. Mattie M, Benz C, Bowers J, Sensinger K, Wong L, Scott G, Fedele V, Ginzinger D, Getts R & Haqq C 2006 Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Molecular Cancer 5 24. (doi:10.1186/1476-4598-5-24)
84. Mayr C & Bartel DP 2009 Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 138 673-684. (doi:10.1016/j.cell.2009.06.016)
85. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R & Tuschl T 2005 Identification of novel argonaute-associated proteins. Current Biology 15 2149-2155. (doi:10.1016/j.cub.2005.10.048)
86. Mellinghoff IK, Vivanco I, Kwon A, Tran C, Wongvipat J & Sawyers CL 2004 HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability. Cancer Cell 6 517-527. (doi:10.1016/j.ccr.2004.09.031)
87. Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C et al. 2009 A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nature Genetics 41 365-370. (doi:10.1038/ng.317)
88. Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, Pennacchio LA, Cheng JF, Nick AM et al. 2008 Dicer, Drosha, and outcomes in patients with ovarian cancer. New England Journal of Medicine 359 2641-2650. (doi:10.1056/NEJMoa0803785)
89. Mertens-Talcott SU, Chintharlapalli S, Li X & Safe S 2007 The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Research 67 11001-11011. (doi:10.1158/0008-5472.CAN-07-2416)
90. Michlewski G & Caceres JF 2010 Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nature Structural & Molecular Biology 17 1011-1018. (doi:10.1038/nsmb.1874)
91. Michlewski G, Guil S, Semple CA & Cáceres JF 2008 Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Molecular Cell 32 383-393. (doi:10.1016/j.molcel.2008.10.013)
92. Mishra S, Deng JJ, Gowda PS, Rao MK, Lin CL, Chen CL, Huang T & Sun LZ 2013 Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer. Oncogene 33 4097-4106. (doi:10.1038/onc.2013.374)
93. Mo W, Zhang J, Li X, Meng D, Gao Y, Yang S, Wan X, Zhou C, Guo F, Huang Y et al. 2013 Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer. PLoS ONE 8 e56592. (doi:10.1371/journal.pone.0056592)
94. Morlando M, Dini Modigliani S, Torrelli G, Rosa A, Di Carlo V, Caffarelli E & Bozzoni I 2012 FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. EMBO Journal 31 4502-4510. (doi:10.1038/emboj.2012.319)
95. Mulholland DJ, Dedhar S, Wu H & Nelson CC 2006 PTEN and GSK3b: key regulators of progression to androgen-independent prostate cancer. Oncogene 25 329-337. (doi:10.1038/sj.onc.1209020)
96. Munagala R, Aqil F, Vadhanam MV & Gupta RC 2013MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. Cancer Letters 339 175-184. (doi:10.1016/j.canlet.2013.06.012)
97. Murata T, Takayama K, Katayama S, Urano T, Horie-Inoue K, Ikeda K, Takahashi S, Kawazu C, Hasegawa A, Ouchi Y et al. 2010 miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. Prostate Cancer and Prostatic Disease 13 356-361.
98. Murphy D, Dancis B & Brown J 2008 The evolution of core proteins involved in microRNA biogenesis. BMC Evolutionary Biology 8 92. (doi:10.1186/1471-2148-8-92)
99. Nadiminty N, Tummala R, Lou W, Zhu Y, Zhang J, Chen X, deVere White RW, Kung HJ, Evans CP & Gao AC 2012 MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. Journal of Biological Chemistry 287 1527-1537. (doi:10.1074/jbc.M111.278705)
100. Nakajima M & Yokoi T 2011 MicroRNAs from biology to future pharmacotherapy: regulation of cytochrome P450s and nuclear receptors. Pharmacology & Therapeutics 131 330-337. (doi:10.1016/j.Pharmthera.2011.04.009)
101. Narayanan R, Jiang J, Gusev Y, Jones A, Kearbey JD, Miller DD, Schmittgen TD & Dalton JT 2010 MicroRNAs are mediators of androgen action in prostate and muscle. PLoS ONE 5 e13637. (doi:10.1371/journal.pone. 0013637)
102. Newman MA & Hammond SM 2010 Emerging paradigms of regulated microRNA processing. Genes and Development 24 1086-1092. (doi:10.1101/gad.1919710)
103. Nothnick W, Healy C & Hong X 2010 Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1. Endocrine 37 265-273. (doi:10.1007/s12020-009-9293-9).
104. O'Connell MA & Keegan LP 2006 Drosha versus ADAR: wrangling over pri-miRNA. Nature Structural & Molecular Biology 13 3-4. (doi:10.1038/nsmb0106-3)
105. Okamura K, Hagen JW, Duan H, Tyler DM & Lai EC 2007 The Mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 130 89-100. (doi:10.1016/j.cell.2007.06.028)
106. Okamura K, Phillips MD, Tyler DM, Duan H, Chou YT & Lai EC 2008 The regulatory activity of microRNA species has substantial influence on microRNA and 3' UTR evolution. Nature Structural & Molecular Biology 15 354-363. (doi:10.1038/nsmb.1409)
107. Östling P, Leivonen SK, Aakula A, Kohonen P, Mäkelä R, Hagman Z, Edsjö A, Kangaspeska S, Edgren H, Nicorici D et al. 2011 Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells. Cancer Research 71 1956-1967. (doi:10.1158/0008-5472.CAN-10-2421)
108. Ozen M, Creighton CJ, Ozdemir M & Ittmann M 2008 Widespread deregulation of microRNA expression in human prostate cancer. Oncogene 27 1788-1793. (doi:10.1038/sj.onc.1210809)
109. Pandey DP & Picard D 2009 miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA. Molecular and Cellular Biology 29 3783-3790. (doi:10.1128/MCB.01875-08)
110. Paroo Z, Ye X, Chen S & Liu Q 2009 Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell 139 112-122. (doi:10.1016/j.cell.2009.06.044)
111. Passon N, Gerometta A, Puppin C, Lavarone E, Puglisi F, Tell G, Di Loreto C & Damante G 2012 Expression of Dicer and Drosha in triple-negative breast cancer. Journal of Clinical Pathology 65 320-326. (doi:10.1136/jclinpath-2011-200496)
112. Pratt AJ & MacRae IJ 2009 The RNA-induced silencing complex: a versatile gene-silencing machine. Journal of Biological Chemistry 284 17897-17901. (doi:10.1074/jbc.R900012200)
113. Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, Zhang W, Tan S, Pandey V, Yao Y et al. 2011 Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Research 71 6463-6474. (doi:10.1158/0008-5472.CAN-11-1322)
114. Qu F, Cui X, Hong Y, Wang J, Li Y, Chen L, Liu Y, Gao Y, Xu D & Wang Q 2013 MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor. Molecular and Cellular Biochemistry 377 121-130. (doi:10.1007/s11010-013-1576-z)
115. Rao X, Di Leva G, Li M, Fang F, Devlin C, Hartman-Frey C, Burow ME, Ivan M, Croce CM & Nephew KP 2011 MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene 30 1082-1097. (doi:10.1038/onc.2010.487)
116. Redfern AD, Colley SM, Beveridge DJ, Ikeda N, Epis MR, Li X, Foulds CE, Stuart LM, Barker A, Russell VJ et al. 2013 RNA-induced silencing complex (RISC) proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. PNAS 110 6536-6541. (doi:10.1073/pnas.1301620110)
117. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR & Ruvkun G 2000 The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403 901-906.
118. Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi AH,Chowdhury WH, Kudrolli TA, Yegnasubramanian S, Luo J, Rodriguez R et al. 2009 miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth. Cancer Research 69 7165-7169. (doi:10.1158/0008-5472.CAN-09-1448)
119. Robb GB & Rana TM 2007 RNA helicase A interacts with RISC in human cells and functions in RISC loading. Molecular Cell 26 523-537. (doi:10.1016/j.molcel.2007.04.016)
120. Rokhlin OW, Scheinker V, Taghiyev AF, Bumcrot D, Glover RA & Cohen MB 2008 MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer. Cancer Biology & Therapy 7 1288-1296. (doi:10.4161/cbt.7.8.6284)
121. Ruby JG, Jan CH & Bartel DP 2007 Intronic microRNA precursors that bypass Drosha processing. Nature 448 83-86. (doi:10.1038/nature05983)
122. Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P & Gherzi R 2009 LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB Journal 23 2898-2908. (doi:10.1096/fj.09-131342)
123. Salzman DW, Shubert-Coleman J & Furneaux H 2007 P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression. Journal of Biological Chemistry 282 32773-32779. (doi:10.1074/jbc.M705054200)
124. Samaan S, Tranchevent LC, Dardenne E, Polay Espinoza M, Zonta E, Germann S, Gratadou L, Dutertre M & Auboeuf D 2013 The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Nucleic Acids Research 42 2197-2207. (doi:10.1093/nar/gkt1216)
125. Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler HA, Barth TF, Möller P, Stilgenbauer S, Pollack JR & Wirth T 2008 MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 112 4202-4212. (doi:10.1182/blood-2008-03-147645)
126. Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS & Benz CC 2007 Coordinate suppression of ERBB2 and ERBB3 by enforced. Expression of micro-RNA miR-125a or miR-125b∗. Journal of Biological Chemistry 282 1479-1486. (doi:10.1074/jbc.M609383200)
127. Shedden K, Taylor JM, Enkemann SA, Tsao MS, Yeatman TJ, Gerald WL, Eschrich S, Jurisica I, Giordano TJ, Misek DE et al. 2008 Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nature Medicine 14 822-827. (doi:10.1038/nm.1790)
128. Shenouda S & Alahari S 2009 MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metastasis Reviews 28 369-378. (doi:10.1007/s10555-009-9188-5)
129. Shi XB, Xue L, Yang J, Ma AH, Zhao J, Xu M, Tepper CG, Evans CP, Kung HJ & deVere White RW 2007 An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. PNAS 104 19983-19988. (doi:10.1073/pnas.0706641104)
130. Shi XB, Xue L, Ma AH, Tepper CG, Kung HJ & White RW 2011 miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes. Prostate 71 538-549. (doi:10.1002/pros.21270)
131. Shu J, Kren BT, Xia Z, Wong PY, Li L, Hanse EA, Min MX, Li B, Albrecht JH, Zeng Y et al. 2011 Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration. Hepatology 54 609-619. (doi:10.1002/hep.24421)
132. Sikand K, Slaibi JE, Singh R, Slane SD & Shukla GC 2011a miR 488∗ inhibits androgen receptor expression in prostate carcinoma cells. International Journal of Cancer 129 810-819. (doi:10.1002/ijc.25753)
133. Sikand K, Barik S & Shukla G 2011b MicroRNAs and androgen receptor 3' untranslated region: a missing link in castration-resistant prostate cancer? Molecular and Cellular Pharmacology 3 107-113.
134. Sirotkin AV, Ovcharenko D, Grossmann R, Lauková M & Mlynček M 2009 Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen. Journal of Cellular Physiology 219 415-420. (doi:10.1002/jcp.21689)
135. Sun T, Wang Q, Balk S, Brown M, Lee G-SM & Kantoff P 2009 The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines. Cancer research 69 3356-3363. (doi:10.1158/0008-5472.can-08-4112).
136. Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S & Miyazono K 2009 Modulation of microRNA processing by p53. Nature 460 529-533. (doi:10.1038/nature08199)
137. Suzuki HI, Arase M, Matsuyama H, Choi YL, Ueno T, Mano H, Sugimoto K & Miyazono K 2011 MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Molecular Cell 44 424-436. (doi:10.1016/j.molcel.2011.09.012)
138. Takata A, Otsuka M, Kojima K, Yoshikawa T, Kishikawa T, Yoshida H & Koike K 2011 MicroRNA-22 and microRNA-140 suppress NF-kB activity by regulating the expression of NF-kB coactivators. Biochemical and Biophysical Research Communications 411 826-831. (doi:10.1016/j.bbrc.2011.07.048)
139. Takayama K, Tsutsumi S, Katayama S, Okayama T, Horie-Inoue K, Ikeda K, Urano T, Kawazu C, Hasegawa A, Ikeo K et al. 2011 Integration of cap analysis of gene expression and chromatin immunoprecipitation analysis on array reveals genome-wide androgen receptor signaling in prostate cancer cells. Oncogene 30 619-630. (doi:10.1038/onc.2010.436)
140. Tokumaru S, Suzuki M, Yamada H, Nagino M & Takahashi T 2008 let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis 29 2073-2077. (doi:10.1093/carcin/bgn187)
141. Tong AW, Fulgham P, Jay C, Chen P, Khalil I, Liu S, Senzer N, Eklund AC, Han J & Nemunaitis J 2008 MicroRNA profile analysis of human prostate cancers. Cancer Gene Therapy 16 206-216.
142. TrabucchiM, Briata P, Garcia-Mayoral M, Haase AD, FilipowiczW, Ramos A, Gherzi R & Rosenfeld MG 2009 The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459 1010-1014. (doi:10.1038/nature08025)
143. Tsuchiya Y, Nakajima M, Takagi S, Taniya T & Yokoi T 2006 MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Research 66 9090-9098. (doi:10.1158/0008-5472.CAN-06-1403)
144. Waltering KK, Porkka KP, Jalava SE, Urbanucci A, Kohonen PJ, Latonen LM, Kallioniemi OP, Jenster G & Visakorpi T 2011 Androgen regulation of micro-RNAs in prostate cancer. Prostate 71 604-614. (doi:10.1002/pros.21276)
145. Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M et al. 2009 Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 138 245-256. (doi:10.1016/j.cell.2009.04.056)
146. Wickramasinghe NS, Manavalan TT, Dougherty SM, Riggs KA, Li Y & Klinge CM 2009 Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Research 37 2584-2595. (doi:10.1093/nar/gkp117)
147. Wightman B, Ha I & Ruvkun G 1993 Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75 855-862. (doi:10.1016/0092-8674(93)90530-4)
148. Wu J, Bao J, Wang L, Hu Y & Xu C 2011 MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesis. BMC Developmental Biology 11 64. (doi:10.1186/1471-213X-11-64)
149. Xhemalce B, Robson SC & Kouzarides T 2012 Human RNA methyl-transferase BCDIN3D regulates microRNA processing. Cell 151 278-288. (doi:10.1016/j.cell.2012.08.041)
150. Xiao J, Gong AY, Eischeid AN, Chen D, Deng C, Young CY & Chen XM 2012 miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. Prostate 72 1514-1522. (doi:10.1002/pros.22501)
151. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, Takeyama KI, Minami Y, O'Malley BW & Kato S 2009 Maturation of microRNA is hormonally regulated by a nuclear receptor. Molecular Cell 36 340-347. (doi:10.1016/j.molcel.2009.08.017)
152. Yang W, Chendrimada TP, Wang Q, Higuchi M, Seeburg PH, Shiekhattar R & Nishikura K 2006 Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nature Structural
153. Yang R, Schlehe B, Hemminki K, Sutter C, Bugert P, Wappenschmidt B, Volkmann J, Varon R, Weber B, Niederacher D et al. 2010 A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. Breast Cancer Research and Treatment 121 693-702. (doi:10.1007/s10549-009-0633-5).
154. Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC & Lai EC 2011 Widespread regulatory activity of vertebrate microRNA∗ species. RNA 17 312-326. (doi:10.1261/rna.2537911).
155. Yang CM, Lu IH, Chen HY & Hu ML 2012 Lycopene inhibits the proliferation of androgen-dependent human prostate tumor cells through activation of PPARγ-LXRα-ABCA1 pathway. Journal of Nutritional Biochemistry 23 8-17. (doi:10.1016/j.jnutbio.2010.10.006)
156. Yeom KH, Lee Y, Han J, Suh MR & Kim VN 2006 Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Research 34 4622-4629. (doi:10.1093/nar/gkl458)
157. Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, Wu K, Whittle J, Ju X, Hyslop T et al. 2008 A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. Journal of Cell Biology 182 509-517. (doi:10.1083/jcb.200801079)
158. Zeng Y, Wagner EJ & Cullen BR 2002 Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Molecular Cell 9 1327-1333. (doi:10.1016/S1097-2765(02)00541-5).
159. Zhang R, He Y, Zhang X, Xing B, Sheng Y, Lu H & Wei Z 2012 Estrogen receptor-regulated microRNAs contribute to the BCL2/BAX imbalance in endometrial adenocarcinoma and precancerous lesions. Cancer Letters 314 155-165. (doi:10.1016/j.canlet.2011.09.027)
160. Zhao JJ, Lin J, Yang H, Kong W, He L, Ma X, Coppola D & Cheng JQ 2008 MicroRNA-221/222 negatively regulates estrogen receptor α and is associated with tamoxifen resistance in breast cancer. Journal of Biological Chemistry 283 31079-31086. (doi:10.1074/jbc.M806041200)
161. Zhao C, Sun G, Li S, Lang MF, Yang S, Li W & Shi Y 2010 MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. PNAS 107 1876-1881. (doi:10.1073/pnas.0908750107)
162. Zhao Y, Deng C, Wang J, Xiao J, Gatalica Z, Recker R & Xiao G 2011 Let-7 family miRNAs regulate estrogen receptor α signaling in estrogen receptor positive breast cancer. Breast Cancer Research and Treatment 127 69-80. (doi:10.1007/s10549-010-0972-2)
163. Zhao J, Imbrie GA, Baur WE, Iyer LK, Aronovitz MJ, Kershaw TB, Haselmann GM, Lu Q & Karas RH 2013 Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology 33 257-265. (doi:10.1161/ATVBAHA.112.300200)