Micrornas are mediators of androgen action in prostate and muscle

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Narayanan, Ramesh ^a   Jiang, Jinmai ^b   Gusev, Yuriy ^c   Jones, Amanda ^a   Kearbey, Jeffrey D ^a   Miller, Duane D ^a   Schmittgen, Thomas D ^b   Dalton, James T ^a  

^a GTx Inc   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; DICER; MICRORNA; NUCLEAR RECEPTOR COREPRESSOR; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN LNCAP; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; HORMONE ACTION; HUMAN; HUMAN CELL; LEVATOR ANI MUSCLE; MALE; MOUSE; NONHUMAN; PROSTATE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; RNA TRANSLATION; TISSUE SPECIFICITY; UPREGULATION; ANIMAL; CHROMATIN IMMUNOPRECIPITATION; MUSCLE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

MUS; RATTUS;

ANDROGENS; ANIMALS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; HUMANS; MALE; MICE; MICRORNAS; MUSCLES; POLYMERASE CHAIN REACTION; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78149442151     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013637     Document Type: Article

References (47)

1. Tsai MJ, O'Malley BW (1994) Molecular mechanisms of action of steroid/ thyroid receptor superfamily members. Annu Rev Biochem 63: 451-486.
2. Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT (2008) Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal 6: e010.
3. Clarke BL, Khosla S (2009) New selective estrogen and androgen receptor modulators. Curr Opin Rheumatol 21: 374-379.
4. De Bosscher K, Haegeman G, Elewaut D (2010) Targeting inflammation using selective glucocorticoid receptor modulators. Curr Opin Pharmacol 10: 497-504.
5. Chen T (2008) Nuclear receptor drug discovery. Curr Opin Chem Biol 12: 418-426.
6. Narayanan R, Coss CC, Yepuru M, Kearbey JD, Miller DD, et al. (2008) Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways. Mol Endocrinol 22: 2448-2465.
7. Li J, Al-Azzawi F (2009) Mechanism of androgen receptor action. Maturitas 63: 142-148.
8. Lonard DM, O'Malley BW (2007) Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell 27: 691-700.
9. Prins GS (2000) Molecular biology of the androgen receptor. Mayo Clin Proc 75(Suppl): S32-S35.
10. Xu J, Wu RC, O'Malley BW (2009) Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer 9: 615-630.
11. Jinek M, Doudna JA (2009) A three-dimensional view of the molecular machinery of RNA interference. Nature 457: 405-412.
12. Kai ZS, Pasquinelli AE (2010) MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat Struct Mol Biol 17: 5-10.
13. Catalucci D, Gallo P, Condorelli G (2009) MicroRNAs in cardiovascular biology and heart disease. Circ Cardiovasc Genet 2: 402-408.
14. Bala S, Marcos M, Szabo G (2009) Emerging role of microRNAs in liver diseases. World J Gastroenterol 15: 5633-5640.
15. Fineberg SK, Kosik KS, Davidson BL (2009) MicroRNAs potentiate neural development. Neuron 64: 303-309.
16. Asli NS, Pitulescu ME, Kessel M (2008) MicroRNAs in organogenesis and disease. Curr Mol Med 8: 698-710.
17. Cortez MA, Calin GA (2009) MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases. Expert Opin Biol Ther 9: 703-711.
18. Vlassov VV, Laktionov PP, Rykova EY (2010) Circulating nucleic acids as a potential source for cancer biomarkers. Curr Mol Med 10: 142-165.
19. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, et al. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 105: 10513-10518.
20. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, et al. (2009) Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell 36: 340-347.
21. Bethke A, Fielenbach N, Wang Z, Mangelsdorf DJ, Antebi A (2009) Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science 324: 95-98.
22. Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi AH, et al. (2009) miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth. Cancer Res 69: 7165-7169.
23. Shi XB, Xue L, Yang J, Ma AH, Zhao J, et al. (2007) An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A 104: 19983-19988.
24. Narayanan R, Adigun AA, Edwards DP, Weigel NL (2005) Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator. Mol Cell Biol 25: 264-277.
25. Saeed AI, Sharov V, White J, Li J, Liang W, et al. (2003) TM4: a free, opensource system for microarray data management and analysis. Biotechniques 34: 374-378.
26. Welch BL (1947) The generalisation of student's problems when several different population variances are involved. Biometrika 34: 28-35.
27. Pan W (2002) A comparative review of statistical methods for discovering differentially expressed genes in replicated microarray experiments. Bioinformatics 18: 546-554.
28. Eisen MB, Spellman PT, Brown PO, Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 95: 14863-14868.
29. Gusev Y (2008) Computational methods for analysis of cellular functions and pathways collectively targeted by differentially expressed micro RNA. Methods 44: 61-72.
30. Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ (2008) miRBase: tools for microRNA genomics. Nucleic Acids Res 36: D154-D158.
31. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, et al. (2002) Identification of tissue-specific microRNAs from mouse. Curr Biol 12: 735-739.
32. Thomson AA (2008) Mesenchymal mechanisms in prostate organogenesis. Differentiation 76: 587-598.
33. Yin D, Gao W, Kearbey JD, Xu H, Chung K, et al. (2003) Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther 304: 1334-1340.
34. Mohler ML, Bohl CE, Jones A, Coss CC, Narayanan R, et al. (2009) Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. J Med Chem 52: 3597-3617.
35. Martini L, Celotti F, Lechuga MJ, Melcangi RC, Motta M, et al. (1990) Androgen metabolism in different target tissues. Ann N Y Acad Sci 595: 184-198.
36. Gentile MA, Nantermet PV, Vogel RL, Phillips R, Holder D, et al. (2010) Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and induction of {beta}-catenin. J Mol Endocrinol 44: 55-73.
37. Tremblay RR, Dube JY, Ho-Kim MA, Lesage R (1977) Determination of rat muscles androgen-receptor complexes with methyltrienolone. Steroids 29: 185-195.
38. Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, et al. (2005) Selective androgen receptor modulator treatment improves muscle strength and bodycomposition and prevents bone loss in orchidectomized rats. Endocrinology 146: 4887-4897.
39. Narayanan R, Yepuru M, Szafran AT, Szwarc M, Bohl CE, et al. (2010) Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer. Cancer Res 70: 842-851.
40. Lee Y, Jeon K, Lee JT, Kim S, Kim VN (2002) MicroRNA maturation: stepwise processing and subcellular localization. Embo J 21: 4663-4670.
41. Yoon HG, Wong J (2006) The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor. MolEndocrinol 20: 1048-1060.
42. Lesche R, Groszer M, Gao J, Wang Y, Messing A, et al. (2002) Cre/loxPmediated inactivation of the murine Pten tumor suppressor gene. Genesis 32: 148-149.
43. Backman SA, Ghazarian D, So K, Sanchez O, Wagner KU, et al. (2004) Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci U S A 101: 1725-1730.
44. Bohl CE, Miller DD, Chen J, Bell CE, Dalton JT (2005) Structural basis foraccommodation of nonsteroidal ligands in the androgen receptor. J Biol Chem 280: 37747-37754.
45. Gonzalez G, Behringer RR (2009) Dicer is required for female reproductive tract development and fertility in the mouse. Mol Reprod Dev 76: 678-688.
46. Hong X, Luense LJ, McGinnis LK, Nothnick WB, Christenson LK (2008) Dicer1 is essential for female fertility and normal development of the female reproductive system. Endocrinology 149: 6207-6212.
47. Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, et al. (2008) Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci 28: 4878-4887.