let-7 regulates Dicer expression and constitutes a negative feedback loop

Carcinogenesis

Volumn 29, Issue 11, 2008, Pages 2073-2077

  Tokumaru, Shogo ^a   Suzuki, Motoshi ^a   Yamada, Hideki ^a   Nagino, Masato ^a   Takahashi, Takashi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CELL PROTEIN; DICER; LUCIFERASE; MESSENGER RNA; MICRORNA; PROTEIN LET 7; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CANCER CELL CULTURE; CELL CYCLE PHASE; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; ENZYME ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; NORTHERN BLOTTING; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CELL DIVISION; CELL LINE; GENE EXPRESSION PROFILING; HELA CELLS; HUMANS; MICRORNAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASE III; RNA, MESSENGER;

EID: 55549127406     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn187     Document Type: Article

References (27)

1. Bartel,D.P. (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116, 281-297.
2. Osada,H. et al. (2007) MicroRNAs in biological processes and carcinogenesis. Carcinogenesis, 28, 2-12.
3. Lee,Y. et al. (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature, 425, 415-419.
4. Hutvagner,G. et al. (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science, 293, 834-838.
5. He,L. et al. (2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nat. Rev. Genet., 5, 522-531.
6. Esquela-Kerscher,A. et al. (2006) Oncomirs-microRNAs with a role in cancer. Nat. Rev. Cancer, 6, 259-269.
7. Takamizawa,J. et al. (2004) Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res., 64, 3753-3756.
8. Hayashita,Y. et al. (2005) A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res., 65, 9628-9632.
9. He,L. et al. (2005) A microRNA polycistron as a potential human oncogene. Nature, 435, 828-833.
10. Zhang,L. et al. (2006) microRNAs exhibit high frequency genomic alterations in human cancer. Proc. Natl Acad. Sci. USA, 103, 9136-9141.
11. O'Donnell,K.A. et al. (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature, 435, 839-843.
12. Saito,Y. et al. (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell, 9, 435-443.
13. Brueckner,B. et al. (2007) The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res., 67, 1419-1423.
14. Thomson,J.M. et al. (2006) Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 20, 2202-2207.
15. Sylvestre,Y. et al. (2007) An E2F/miR-20a autoregulatory feedback loop. J. Biol. Chem., 282, 2135-2143.
16. Fazi,F. et al. (2005) A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell, 123, 819-831.
17. Matsubara,H. et al. (2007) Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene, 26, 6099-6105.
18. Johnson,S.M. et al. (2005) RAS is regulated by the let-7 microRNA family. Cell, 120, 635-647.
19. Lee,Y.S. et al. (2007) The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev., 21, 1025-1030.
20. Krek,A. et al. (2005) Combinatorial microRNA target predictions. Nat. Genet., 37, 495-500.
21. Lim,L.P. et al. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature, 433, 769-773.
22. Lu,J. et al. (2005) MicroRNA expression profiles classify human cancers. Nature, 435, 834-838.
23. Kumar,M.S. et al. (2007) Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat. Genet., 39, 673-677.
24. Karube,Y. et al. (2005) Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci., 96 111-115.
25. Johnson,C.D. et al. (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res., 67, 7713-7722.
26. Chang,T.C. et al. (2008) Widespread microRNA repression by Myc contributes to tumorigenesis. Nat. Genet., 40, 43-50.
27. Sampson,V.B. et al. (2007) MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res., 67, 9762-9770.