Anthraquinone G503 induces apoptosis in gastric cancer cells through the mitochondrial pathway

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Huang, Lijun ^a   Zhang, Ting ^a   Li, Shuai ^a   Duan, Junting ^a   Ye, Fang ^a   Li, Hanxiang ^b   She, Zhigang ^b   Gao, Guoquan ^a,b   Yang, Xia ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; G 503; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; BENZYLOXYCARBONYL-ISOLEUCYL-GLUTAMYL-THREONYL-ASPARTIC ACID FLUOROMETHYL KETONE; BENZYLOXYCARBONYL-LEUCYL-GLUTAMYL-HISTIDYL-ASPARTIC ACID FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP4 PROTEIN, HUMAN; CASPASE INHIBITOR; G503 COMPOUND; INITIATOR CASPASE; OLIGOPEPTIDE; PEPTIDE CHLOROMETHYL KETONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOSIS INHIBITION; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; PROTEIN SECRETION; AGONISTS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MITOCHONDRION; PATHOLOGY; SACCHAROMYCETALES; SIGNAL TRANSDUCTION; STOMACH MUCOSA; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

AMINO ACID CHLOROMETHYL KETONES; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITORS; CASPASES, INITIATOR; CELL LINE, TUMOR; EPITHELIAL CELLS; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MITOCHONDRIA; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; SACCHAROMYCETALES; SIGNAL TRANSDUCTION;

EID: 84907484374     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108286     Document Type: Article

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