VEGF protects bovine aortic endothelial cells from TNF-α- and H2O2-induced apoptosis via co-modulatory effects on p38- and p42/p44-CCDPK signaling

Acta Pharmacologica Sinica

Volumn 23, Issue 1, 2002, Pages 45-49

  Liu, Wen Lan ^a   Guo, Xun ^a   Chen, Qing Quan ^a   Guo, Zhao Gui ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Ca2+ calmodulin dependent protein kinase; Cultured cells; DNA fragmentation; Endothelial growth factors; Hydrogen peroxide; Tumor necrosis factor; Vascular endothelium; Westem blotting

Indexed keywords

DNA FRAGMENT; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ENDOTHELIAL CELL GROWTH FACTOR; LYMPHOKINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; SIGNAL PEPTIDE; VASCULOTROPIN A;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; FLUORESCENCE MICROSCOPE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; AORTA; CATTLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; DRUG INTERACTION; METABOLISM; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CATTLE; CELLS, CULTURED; DRUG INTERACTIONS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HYDROGEN PEROXIDE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 14; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036147227     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. The pathogenesis of atherosclerosis: A perspective for the 1990's
2. Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?
3. 2-induced apoptosis in bovine aortic endothelial cells
4. Opposing effect of p38 CCDPK and p42/p44 CCDPK signaling on TNF-α-induced apoptosis in bovine aortic endothelial cells
5. Molecular and biological properties of the vascular endothelial cell growth factor family of proteins
6. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-α: Balance between growth and death signals
7. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
8. 2-induced apoptosis in PC12 cells by glutathione independent mechanism
9. Inhibition of hydrogen peroxide-induced apoptosis but not arachidonic acid release in GH3 cell by EGF
10. A new role for vascular endothelial growth factor and fibroblast growth factors: Increasing endothelial resistance to oxidative stress
11. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: Role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death
12. Association of apoptosis with the inhibition of extracellular signal-regulated protein kinase activity in the tumor necrosis factor alpha-resistant ovarian carcinoma cell line UCI 101
13. Effects of lysophosphatidylcholine on bovine aortic endothelial cells in culture
14. Regulation of distinct steps of angiogenesis by different angiogenic molecules
15. Apoptosis induced by inhibition of intercellular contact
16. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
17. The stress-activated protein kinase pathways
18. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
19. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway
20. Therapeutic angiogenesis: The new electrophysiology?