SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway

Oncology Reports

Volumn 29, Issue 6, 2013, Pages 2341-2347

  Wang, Dujuan ^a   Wang, Sumei ^a   Liu, Qin ^a   Wang, Mengyao ^a   Wang, Chunhua ^a   Yang, Huiling ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Human nasopharyngeal carcinoma; miR 205; Radioresistance; Stat3

Indexed keywords

ANTHRACYCLINE DERIVATIVE; CELL PROTEIN; DEATH RECEPTOR; JAB1 PROTEIN; MICRORNA 205; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P27; STAT3 PROTEIN; SZ 685C; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL STRAIN CNE2R; CELL SURVIVAL; CYTOTOXICITY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; IRRADIATION; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN TARGETING; RADIOSENSITIVITY;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SHAPE; CELL SURVIVAL; HUMANS; INHIBITORY CONCENTRATION 50; MICRORNAS; NASOPHARYNGEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RADIATION TOLERANCE;

EID: 84876233557     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2376     Document Type: Article

References (28)

1. Her C: Nasopharyngeal cancer and the Southeast Asian patient. Am Fam Physician 63: 1776-1782, 2001.
2. Lo KW, To KF and Huang DP: Focus on nasopharyngeal carcinoma. Cancer Cell 5: 423-428, 2004. (Pubitemid 38612865)
3. Qin L, Zhang X, Zhang L, et al: Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells. Biochem Biophys Res Commun 371: 531-535, 2008.
4. Schoof CR, Botelho EL, Izzotti A and Vasques Ldos R: MicroRNAs in cancer treatment and prognosis. Am J Cancer Res 2: 414-433, 2012.
5. Lee KM, Choi EJ and Kim IA: microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. Radiother Oncol 101: 171-176, 2011.
6. Jeong SH, Wu HG and Park WY: LIN28B confers radio-resistance through the posttranscriptional control of KRAS. Exp Mol Med 41: 912-918, 2009.
7. Tian W, Chen J, He H and Deng Y: MicroRNAs and drug resistance of breast cancer: basic evidence and clinical applications. Clin Transl Oncol: Aug 23, 2012 (Epub ahead of print).
8. Kanakkanthara A and Miller JH: MicroRNAs: novel mediators of resistance to microtubule-targeting agents. Cancer Treat Rev 39: 161-70, 2012.
9. Qu C, Liang Z, Huang J, et al: MiR-205 determines the radio-resistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell Cycle 11: 785-796, 2012.
10. She Z, Chen S, Lin Y, Yuan J, Pang J and Li M: SZ-685C preparation method and antitumor application. Application No: 00810028628.3, Application Date: 2008.6.6.
11. Xie G, Zhu X, Li Q, et al: SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway. Br J Pharmacol 159: 689-697, 2010.
12. Zhang Y, Gan B, Liu D and Paik JH: FoxO family members in cancer. Cancer Biol Ther 12: 253-259, 2011.
13. Zhu X, He Z, Wu J, et al: A marine anthraquinone SZ-685C overrides adriamycin-resistance in breast cancer cells through suppressing Akt signaling. Mar Drugs 10: 694-711, 2012.
14. Hitomi J, Katayama T, Eguchi Y, et al: Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol 165: 347-356, 2004. (Pubitemid 38649910)
15. Tadros SF, D'Souza M, Zhu X and Frisina RD: Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis 13: 1303-1321, 2008.
16. LoPiccolo J, Granville CA, Gills JJ and Dennis PA: Targeting Akt in cancer therapy. Anticancer Drugs 18: 861-874, 2007. (Pubitemid 47220704)
17. Eke I, Koch U, Hehlgans S, et al: PINCH1 regulates Akt1 activation and enhances radio-resistance by inhibiting PP1alpha. J Clin Invest 120: 2516-2527, 2010.
18. Song MS, Salmena L and Pandolfi PP: The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13: 283-296, 2012.
19. Li SS, Yang S, Wang S, Yang XM, Tang QL and Wang SH: Latent membrane protein 1 mediates the resistance of nasopharyngeal carcinoma cells to TRAIL-induced apoptosis by activation of the PI3K/Akt signaling pathway. Oncol Rep 26: 1573-1579, 2011.
20. Kraus AC, Ferber I, Bachmann SO, et al: In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways. Oncogene 21: 8683-8695, 2002. (Pubitemid 36132389)
21. Tomoda K, Kubota Y and Kato J: Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature 398: 160-165, 1999.
22. Oh W, Lee EW, Sung YH, et al: Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. J Biol Chem 281: 17457-17465, 2006.
23. Wan M, Cao X, Wu Y, et al: Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep 3: 171-176, 2002. (Pubitemid 34213496)
24. Pan Y, Zhang Q, Tian L, et al: Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma. Cancer Res 72: 1890-1900, 2012.
25. Shackleford TJ, Zhang Q, Tian L, et al: Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells. Breast Cancer Res 13: R65, 2011.
26. Zhang J, Chen F, Li W, et al: 14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells. PLoS One 7: e29554, 2012.
27. Azijli K, Yuvaraj S, Peppelenbosch MP, et al: Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3 dependent invasion in resistant non-small cell lung cancer cells. J Cell Sci 125: 4651-4661, 2012.
28. Chen F: JNK dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure. Toxicol Sci 129: 363-371, 2012.