Quinone isomers of the WS-5995 antibiotics: Synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation, and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro

Anti-Cancer Drugs

Volumn 12, Issue 5, 2001, Pages 401-417

  Perchellet, Elisabeth M ^a   Sperfslage, Bonnie J ^a   Qabaja, Ghassan ^b   Jones, Graham B ^b   Perchellet, Jean Pierre ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Apoptosis; DNA cleavage; Ellagic acid; Genistein; L1210 cells; Macromolecule synthesis; Mitotic index; Nucleoside transport; Tumor cell growth and viability; WS 5995 antibiotics

Indexed keywords

1,10 DIMETHOXY 8 METHYL 11,12 DIHYDRO 6H DIBENZO[C,H]CHROMENE 6,11,12 TRIONE; 7,12 DIHYDRO 5H DIBENZO[C,G]CHROMENE 5,7,12 TRIONE; ANTINEOPLASTIC ANTIBIOTIC; CASPASE; CYCLOHEXIMIDE; DACTINOMYCIN; DNA FRAGMENT; ELLAGIC ACID; ENDONUCLEASE; GENISTEIN; KETONE; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; QUINONE DERIVATIVE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG; WS 5995; WS 5995A; ZINC SULFATE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DNA SYNTHESIS INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVATION; ISOMER; LEUKEMIA CELL; MITOSIS INDEX; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL SURVIVAL; COUMARINS; DNA FRAGMENTATION; DNA, NEOPLASM; ELLAGIC ACID; GENISTEIN; ISOMERISM; LEUKEMIA L1210; MITOSIS; MITOTIC INDEX; NEOPLASM PROTEINS; QUINONES; RNA, NEOPLASM;

EID: 0034932934     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200106000-00002     Document Type: Article

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