A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26430-26440

  Shkriabai, Nikoloz ^a   Dharmarajan, Venkatasubramanian ^b   Slaughter, Alison ^a   Kessl, Jacques J ^a   Larue, Ross C ^a   Feng, Lei ^a   Fuchs, James R ^a   Griffin, Patrick R ^b   Kvaratskhelia, Mamuka ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL SEGMENTS; HIV-1 INTEGRASE; MULTIMERIZATION;

ALLOSTERIC INTEGRASE INHIBITOR 2; INTEGRASE INHIBITOR; LYSINE; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; ALLINI-2; INDOLE DERIVATIVE; INTEGRASE; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEIN BINDING;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; MASS SPECTROMETRY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN FOOTPRINTING; PROTEIN LOCALIZATION; PROTEIN MULTIMERIZATION; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; ALLOSTERISM; ANTIVIRAL RESISTANCE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; MISSENSE MUTATION;

ACETATES; ALLOSTERIC REGULATION; DRUG RESISTANCE, VIRAL; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INDOLES; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN MULTIMERIZATION;

EID: 84907222847     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.589572     Document Type: Article

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