Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16801-16811

  Kessl, Jacques J ^a   Jena, Nivedita ^b   Koh, Yasuhiro ^c   Taskent Sezgin, Humeyra ^b   Slaughter, Alison ^a   Feng, Lei ^a   De Silva, Suresh ^d   Wu, Li ^d   Le Grice, Stuart F J ^b   Engelman, Alan ^c   Fuchs, James R ^b   Kvaratskhelia, Mamuka ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID DERIVATIVE; ALLOSTERIC INHIBITOR; ANTIVIRAL THERAPY; CLINICAL PARAMETERS; COFACTORS; COOPERATIVE MECHANISMS; COOPERATIVITY; HIV-1 INTEGRASE; HOST CELLS; IN-VITRO; INFECTED CELLS; INTEGRASE; MECHANISM OF ACTION; MULTIMERIC; MULTIMODES; SYNAPTIC COMPLEX; VIRAL DNA;

CELL CULTURE; DNA; PH;

ACETIC ACID;

2 (6 BROMO 4 (4 CHLOROPHENYL) 2 METHYLQUINOLIN 3 YL) 2 METHOXYACETIC ACID; 2 (6 CHLORO 2 METHYL 4 PHENYLQUINOLIN 3 YL)PENTANOIC ACID; 2 (QUINOLIN 3 YL)ACETIC ACID DERIVATIVE; ASPARAGINE; BI 1001; GLUTAMINE; HISTIDINE; INTEGRASE INHIBITOR; ISOLEUCINE; LENS EPITHELIUM DERIVED GROWTH FACTOR; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS DNA;

ALLOSTERISM; ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNAPSE; VIRUS REPLICATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLOSTERIC REGULATION; DNA, VIRAL; HEK293 CELLS; HIV INFECTIONS; HIV INTEGRASE; HIV-1; HUMANS; INDOLEACETIC ACIDS; INTEGRASE INHIBITORS; PROTEIN BINDING; TRANSCRIPTION FACTORS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84860871902     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.354373     Document Type: Article

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