Allosteric inhibition of human immunodeficiency virus integrase: Late block during viral replication and abnormal multimerization involving specific protein domains

Journal of Biological Chemistry

Volumn 289, Issue 30, 2014, Pages 20477-20488

  Gupta, Kushol ^a   Brady, Troy ^a   Dyer, Benjamin M ^a   Malani, Nirav ^a   Hwang, Young ^a   Male, Frances ^a   Nolte, Robert T ^b   Wang, Liping ^b   Velthuisen, Emile ^b   Jeffrey, Jerry ^b   Van Duyne, Gregory D ^a   Bushman, Frederic D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; INTEGRASE INHIBITOR; PSIP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

ALLOSTERISM; CELL LINE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLOSTERIC REGULATION; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS; VIRUS REPLICATION;

EID: 84905390193     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.551119     Document Type: Article

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