The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15813-15820

  Feng, Lei ^a   Sharma, Amit ^a   Slaughter, Alison ^a   Jena, Nivedita ^a   Koh, Yasuhiro ^b   Shkriabai, Nikolozi ^a   Larue, Ross C ^a   Patel, Pratiq A ^a   Mitsuya, Hiroaki ^b   Kessl, Jacques J ^a   Engelman, Alan ^c,d   Fuchs, James R ^a   Kvaratskhelia, Mamuka ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-HIV-1 AGENTS; DIMER INTERFACE; DRUG RESISTANCE; HIV-1 INTEGRASE; MECHANISM OF ACTION; MULTIMERIZATION; PRIMARY MECHANISM; PROTEIN MULTIMERIZATION;

CELL CULTURE; HYDROGEN BONDS; OLIGOMERS;

VIRUSES;

ALANINE; DIMER; INTEGRASE; INTEGRASE INHIBITOR; LENS EPITHELIUM DERIVED GROWTH FACTOR; OLIGOMER; PROTEIN P75; THREONINE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN MULTIMERIZATION; VIRION; VIRUS INFECTIVITY; VIRUS REPLICATION;

ALLOSTERIC INHIBITORS; DRUG RESISTANCE; HIV-1; INFECTIOUS DISEASES; INTEGRASE; PHARMACOLOGY; PROTEIN-DNA INTERACTIONS; PROTEIN-DRUG INTEGRATIONS; PROTEIN-PROTEIN INTERACTIONS; STRUCTURAL BIOLOGY;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; DRUG RESISTANCE, VIRAL; HEK293 CELLS; HELA CELLS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84878408619     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.443390     Document Type: Article

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