HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

Nucleic Acids Research

Volumn 40, Issue 22, 2012, Pages 11518-11530

  Wang, Hao ^a   Jurado, Kellie A ^a   Wu, Xiaolin ^b   Shun, Ming Chieh ^a   Li, Xiang ^a   Ferris, Andrea L ^c   Smith, Steven J ^c   Patel, Pratiq A ^d   Fuchs, James R ^d   Cherepanov, Peter ^e   Kvaratskhelia, Mamuka ^d   Hughes, Stephen H ^c   Engelman, Alan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SAIC FREDERICK INC   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOMA DERIVED GROWTH FACTOR; HEPATOMA DERIVED GROWTH FACTOR RELATED PROTEIN; INTEGRASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN INHIBITOR; PROTEIN P75; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DEPLETION; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HDGFRP2 GENE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PSIP1 GENE; TREATMENT RESPONSE; VIRUS DNA CELL DNA INTERACTION; VIRUS GENE;

ACETATES; ANIMALS; BINDING SITES; CELL LINE; FIBROBLASTS; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; QUINOLINES; VIRUS INTEGRATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

EID: 84871220094     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks913     Document Type: Article

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