A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase

PLoS Pathogens

Volumn 10, Issue 5, 2014, Pages

  Sharma, Amit ^a   Slaughter, Alison ^a   Jena, Nivedita ^a   Feng, Lei ^a   Kessl, Jacques J ^a   Fadel, Hind J ^b   Malani, Nirav ^c   Male, Frances ^c   Wu, Li ^a   Poeschla, Eric ^b   Bushman, Frederic D ^c   Fuchs, James R ^a   Kvaratskhelia, Mamuka ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Mayo Clinic College of Medicine   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLINI INHIBITOR; BI 1001; GS B; INTEGRASE INHIBITOR; KF 115; KF 116; NEVIRAPINE; RALTEGRAVIR; SAQUINAVIR; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; INTEGRASE; LENS EPITHELIUM-DERIVED GROWTH FACTOR; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEIN BINDING; QUINOLINE; QUINOLINE DERIVATIVE; SIGNAL PEPTIDE;

ANTIVIRAL ACTIVITY; ARTICLE; BIOINFORMATICS; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; GENE MUTATION; HUMAN; HUMAN CELL; IC 50; OLIGOMERIZATION; POLYMERASE CHAIN REACTION; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PYROSEQUENCING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; TRANSMISSION ELECTRON MICROSCOPY; VIRUS REPLICATION; WESTERN BLOTTING; CELL LINE; DRUG EFFECTS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; VIRUS DNA CELL DNA INTERACTION;

ANTIVIRAL AGENTS; CELL LINE; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; QUINOLINES; VIRUS INTEGRATION; VIRUS REPLICATION;

EID: 84901657154     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004171     Document Type: Article

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