Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the warburg effect

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26533-26541

  Fan, Jun ^a   Kang, Hee Bum ^a   Shan, Changliang ^a   Elf, Shannon ^a   Lin, Ruiting ^a   Xie, Jianxin ^b   Gu, Ting Lei ^b   Aguiar, Mike ^b   Lonning, Scott ^b   Chung, Tae Wook ^a   Arellano, Martha ^a   Khoury, Hanna J ^a   Shin, Dong M ^a   Khuri, Fadlo R ^a   Boggon, Titus J ^c   Kang, Sumin ^a   Chen, Jing ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRUVATES; SUBSTRATE BINDING; WARBURG EFFECTS;

EPIDERMAL GROWTH FACTOR; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE ALPHA 1; PYRUVIC ACID; SERINE; TYROSINE; UNCLASSIFIED DRUG; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; PROTEIN BINDING; PYRUVATE DEHYDROGENASE E1ALPHA SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CELL HYPOXIA; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LUNG CANCER; METABOLIC PARAMETERS; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WARBURG EFFECT; 3T3 CELL LINE; AMINO ACID SUBSTITUTION; ANIMAL; CANCER TRANSPLANTATION; CARBOHYDRATE METABOLISM; CHEMISTRY; GENETICS; METABOLISM; NUDE MOUSE; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; TUMOR CELL LINE; TUMOR VOLUME;

3T3 CELLS; AMINO ACID SUBSTITUTION; ANIMALS; CARBOHYDRATE METABOLISM; CATALYTIC DOMAIN; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; EPIDERMAL GROWTH FACTOR; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OXIDATIVE PHOSPHORYLATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRUVATE DEHYDROGENASE (LIPOAMIDE); PYRUVIC ACID; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; TUMOR BURDEN; TYROSINE;

EID: 84907218413     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.593970     Document Type: Article

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