Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 21240-21246

  Ciszak, Ewa M ^a   Korotchkina, Lioubov G ^b   Dominiak, Paulina M ^a   Sidhu, Sukhdeep ^b   Patel, Mulchand S ^b  

^a UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DERIVATIVES; ENZYMES; VITAMINS;

DEHYDROGENASE;

BIOCHEMISTRY;

COCARBOXYLASE; COCARBOXYLASE DEPENDENT ENZYME; DIHYDROLIPOAMIDE ACETYLTRANSFERASE; HOLOENZYME; LIPOYLDIHYDROLIPOAMIDE ACETYLTRANSFERASE; PYRUVATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; DEGRADATION; DOUBLE BOND CLEAVAGE; ENERGY YIELD; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FAMILY;

AMINO ACID SEQUENCE; CARBOXY-LYASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ESCHERICHIA COLI; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRUVATE DEHYDROGENASE (LIPOAMIDE); PYRUVATE DEHYDROGENASE COMPLEX; STRUCTURE-ACTIVITY RELATIONSHIP; THIAMINE PYROPHOSPHATE; TRANSKETOLASE;

EID: 0038418364     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300339200     Document Type: Article

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