Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth

Journal of Biological Chemistry

Volumn 289, Issue 31, 2014, Pages 21413-21422

  Shan, Changliang ^a   Kang, Hee Bum ^a   Elf, Shannon ^a   Xie, Jianxin ^b   Gu, Ting Lei ^b   Aguiar, Mike ^b   Lonning, Scott ^b   Hitosugi, Taro ^a,d   Chung, Tae Wook ^a   Arellano, Martha ^a   Khoury, Hanna J ^a   Shin, Dong M ^a   Khuri, Fadlo R ^a   Boggon, Titus J ^c   Fan, Jun ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; AMINO ACIDS; CELL PROLIFERATION; MITOCHONDRIA; PATHOLOGY; PHOSPHATASES; TUMORS;

HUMAN CANCER CELLS; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION; OXIDATIVE PHOSPHORYLATION; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE KINASE; SERINE PHOSPHORYLATION; TYROSINE PHOSPHORYLATION;

PHOSPHORYLATION;

DIHYDROLIPOAMIDE ACETYLTRANSFERASE; MUTANT PROTEIN; PHENYLALANINE; PROTEIN PDP1; PROTEIN TYR 94; PROTEIN TYROSINE KINASE; PYRUVATE DEHYDROGENASE PHOSPHATASE; THIOCTIC ACID; TYROSINE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; LACTIC ACID; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL HYPOXIA; CELL PROLIFERATION; COVALENT BOND; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; TUMOR XENOGRAFT; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIVISION; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; OXYGEN CONSUMPTION; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL DIVISION; CELL LINE, TUMOR; DNA PRIMERS; HUMANS; LACTIC ACID; MOLECULAR SEQUENCE DATA; NEOPLASMS; OXYGEN CONSUMPTION; PHOSPHORYLATION; PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SEQUENCE HOMOLOGY, AMINO ACID; TYROSINE;

EID: 84905383307     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.581124     Document Type: Article

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