Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents

Bioorganic Chemistry

Volumn 57, Issue , 2014, Pages 65-82

  Abdel Atty, Mona M ^a   Farag, Nahla A ^a   Kassab, Shaymaa E ^b   Serya, Rabah A T ^c   Abouzid, Khaled A M ^c  

^a Egypt   (Egypt)

^b DAMANHOUR UNIVERSITY   (Egypt)

^c African Union Organization St Abbassia   (Egypt)

Author keywords

3D QSAR pharmacophore model; Cytotoxic activity; Histone deacetylase; Synthesis

Indexed keywords

2 [[4 (1H IMIDAZOL 1 YL)PHENYL]CARBAMOYL]BENZOIC ACID; 2 [[4 (4 METHYLPIPERAZIN 1 YL)PHENYL]CARBAMOYL]BENZOIC ACID; 3 (4 MORPHOLINOPHENYL)ACRYLIC ACID; 3 [4 (1H IMIDAZOL 1 YL)PHENYL]ACRYLIC ACID; 3 [4 (4 METHYLPIPERAZIN 1 YL)PHENYL]ACRYLIC ACID; 3 [4 (4 PHENYLPIPERAZIN 1 YL)PHENYL]ACRYLIC ACID; 3 [4 (PIPERIDIN 1 YL)PHENYL]ACRYLIC ACID; 3 [4 (PYRROLIDIN 1 YL)PHENYL]ACRYLIC ACID; 3 [4 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL)PHENYL]]ACRYLIC ACID; 4 [4 (1H IMIDAZOL 1 YL)PHENYLAMINO] 4 OXOBUTANOIC ACID; 4 [4 (4 METHYLPIPERAZIN 1 YL)PHENYLAMINO] 4 OXOBUTANOIC ACID; 4 [4 (PYRROLIDIN 1 YL)PHENYLAMINO] 4 OXOBUTANOIC ACID; 5 [4 (1H IMIDAZOL 1 YL)PHENYLAMINO] 5 OXOPENTANOIC ACID; 5 [4 (4 PHENYLPIPERAZIN 1 YL)PHENYLAMINO] 5 OXOPENTANOIC ACID; 6 (4 MORPHOLINOPHENYL)4 OXO HEX 5 ENOIC; 6 [4 (4 METHYLPIPERAZIN 1 YL)PHENYL] 4 OXO HEX 5 ENOIC ACID; 6 [4 (4 PHENYLPIPERAZIN 1 YL)PHENYL] 4 OXOHEX 5 ENOIC ACID; 6 [4 (PIPERIDIN 1 YL)PHENYL] 4 OXO HEX 5 ENOIC ACID; 6 [4 (PYRROLIDIN 1 YL)PHENYL] 4 OXO HEX 5 ENOIC ACID; CARBOXYLIC ACID DERIVATIVE; CYTOTOXIC AGENT; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYTOTOXIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION ASSAY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC50; LIVER CANCER CELL LINE; MOLECULAR DOCKING; NON SMALL CELL LUNG CANCER; PHARMACOPHORE; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG SCREENING; ENZYMOLOGY; METABOLISM; NEOPLASMS; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYTOTOXINS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MODELS, MOLECULAR; NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907214942     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2014.08.006     Document Type: Article

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