Synthesis and QSAR study of novel cytotoxic spiro[3H-indole-3, 2′(1′H)-pyrrolo[3,4-c]pyrrole]-2,3′,5′(1H,2′aH, 4′H)-triones

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 312-322

  Girgis, Adel S ^a   Stawinski, Jacek ^b   Ismail, Nasser S M ^c   Farag, Hanaa ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c African Union Organization St Abbassia   (Egypt)

Author keywords

1H pyrrole 2,5 diones; Anti tumor; Azomethine ylides; QSAR; Spiro 3H indole 3, 2 (1 H) pyrrolo 3,4 c pyrrole

Indexed keywords

4' (4 CHLOROPHENYL) 5'A,6' DIHYDRO 1' METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 4' (4 CHLOROPHENYL) 5'A,6' DIHYDRO 5 METHOXY 1' METHYLSPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5 CHLORO 4' (4 CHLOROPHENYL) 5'A,6' DIHYDRO 1' METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5 CHLORO 5'A,6' DIHYDRO 1' METHYL 4' (4 METHYLPHENYL)SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5 CHLORO 5'A,6' DIHYDRO 1' METHYL 4' PHENYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5 CHLORO 5'A,6' DIHYDRO 4' (4 FLUOROPHENYL) 1' METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5 CHLORO 5'A,6' DIHYDRO 4' (4 METHOXYPHENYL) 10 METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 1' METHYL 4' (4 METHYLPHENYL)SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 1' METHYL 4' PHENYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 4' (4 FLUOROPHENYL) 1' METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 4' (4 FLUOROPHENYL) 5 METHOXY 1' METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 4' (4 METHOXYPHENYL) 1' METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 5 METHOXY 1' METHYL 4' (4 METHYLPHENYL)SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 5 METHOXY 1' METHYL 4' PHENYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; 5'A,6' DIHYDRO 5 METHOXY 4' (4 METHOXYPHENYL) 1' METHYL SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; CYTOTOXIC AGENT; DOXORUBICIN; SPIRO COMPOUND; SPIRO(3H INDOLE 3,2' (1'H) PYRROLO[3,4 C]PYRROLE) 2,3',5' (1H,2'AH,4'H)TRIONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL STRAIN HCT116; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONTROLLED STUDY; CYCLOADDITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; POLYMERIZATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; SPIRO COMPOUNDS;

EID: 84855797583     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.058     Document Type: Article

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