Novel benzothiazole, benzimidazole and benzoxazole derivatives as potential antitumor agents: Synthesis and preliminary in Vitro biological evaluation

Molecules

Volumn 17, Issue 1, 2012, Pages 873-883

  Xiang, Pu ^a   Zhou, Tian ^a   Wang, Liang ^a   Sun, Chang Yan ^a   Hu, Jing ^a   Zhao, Ying Lan ^a   Yang, Li ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Antitumor; Benzimidazole; Benzothiazole derivatives; Benzoxazole; Cytosolic vacuolization

Indexed keywords

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE;

ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HUMAN; IC 50; SOLUBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BENZOTHIAZOLES; BENZOXAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862935441     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17010873     Document Type: Article

References (8)

1. The Global Burden of Disease: 2004 Update; World Health Organization: Geneva, Switzerland, 2008.
2. Wang, Z.; Shi, X.-H.; Wang, J.; Zhou, T.; Xu, Y.-Z.; Huang, T.-T.; Li, Y.-F.; Zhao, Y.-L.; Yang, L.; Yang, S.-Y.; et al. Synthesis, structure-activity relationships and preliminary antitumor evalutation of benzothiazole-2-thiol derivatives as novel apoptosis inducers. Bioorg. Med. Chem. Lett. 2011, 21, 1907-1101.
3. Capdeville, R.; Buchdunger, E.; Zimmermann, J.; Matter, A. Glivec (STI571, imatinib), a rationaly developed, targeted anticancer drug. Nat. Rev. Drug Discov. 2002, 1, 493-502.
4. Baraldi, P.G.; Preti, D.; Tabrizi, M.A.; Fruttarolo, F.; Saponaro, G.; Baraldi, S.; Romagnoli, R.; Moorman, AR.; Gessi, S.; Varani, K.; Borea, P.A. N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoylmethoxy- phenyl]-(2-chloro)-5'-N- ethylcarboxamido-adenosines: The first example of adenosinerelated structures with potent agonist activity at the human A(2B) adenosine receptor. Bioorg. Med. Chem. 2007, 15, 2514-2527. (Pubitemid 46367714)
5. Mussom, D.L.; Cochran, F.R.; Kelley, J.L.; Mclean, E.W.; Selph, J.L.; Rigdon, G.C.; Orr, G.F.; Davis, R.G.; Cooper, B.R.; Styles, V.L.; et al. Indanylidenes. 1. Design and synthesis of (E)-2-(4, 6-difluoro-1-indanylidene) acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity. J. Med. Chem. 2003, 46, 399-408. (Pubitemid 36139791)
6. Mimnaugh, E.G.; Xu, W.; Vos, M. Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity. Mol. Cancer Ther. 2004, 3, 551-566. (Pubitemid 39193734)
7. Wynne, G.M.; Wren, S.P.; Johnson, P.D.; Price, P.D.; De Moor, O.; Nugent, G.; Storer, R.; Pye, R.J.; Dorgan, C.R. Treatment of duchenne muscular dystrophy. WO 2007/091106 A2, 16 August 2007.
8. Kanzawa, T.; Kondo, Y.; Ito, H.; Kondo, S.; Germano, I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res. 2003, 63, 2103-2108. (Pubitemid 36538613)