6-aryl-4-oxohexanoic acids: Synthesis, effects on eicosanoid biosynthesis, and anti-inflammatory in vivo-activities

Medicinal Chemistry

Volumn 3, Issue 5, 2007, Pages 433-438

  Abouzid, Khaled ^a,b   Frohberg, Petra ^c   Lehmann, Jochen ^b   Decker, Michael ^b  

^a Ain Shams University   (Egypt)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

5 lipoxgenase; 6 aryl 4 oxohexanoic acids; Arachidonic acid metabolism; Inflammation; NSAIDs; Rat paw edema test

Indexed keywords

6 (2 FLUOROBIPHENYL 4 YL) 4 OXOHEX 5 ENOIC ACID; 6 (2,3 DIHYDRO 1,4 BENZODIOXIN 6 YL) 4 OXOHEX 5 ENOIC ACID; 6 ARYL 4 OXOHEX 5 ENOIC ACID DERIVATIVE; 6 ARYL 4 OXOHEXANOIC ACID DERIVATIVE; 6 BIPHENYL 4 YL 4 OXOHEX 5 ENOIC ACID; ACETIC ACID; ALDEHYDE DERIVATIVE; ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; ARYLIDENE DERIVATIVE; BUCLOXIC ACID; CARBON; CARRAGEENAN; FENBUFEN; FLOBUFEN; FLURBIPROFEN; HYDROGEN; ICOSANOID; LACTONE DERIVATIVE; LEVULINIC ACID; LIPOXYGENASE; LUMIRACOXIB; NABUMETONE; NONSTEROID ANTIINFLAMMATORY AGENT; PALLADIUM; PIPERIDINE; PROSTAGLANDIN SYNTHASE; TOLUENE; TREPIBUTONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MELTING POINT; NONHUMAN; PAW EDEMA; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; ROOM TEMPERATURE; SINGLE DRUG DOSE; STRUCTURE ANALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE INHIBITORS; EICOSANOIDS; HEXANOIC ACIDS; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED;

EID: 34748823562     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607781745393     Document Type: Article

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