Reversal of multidrug resistance in vitro by co-delivery of MDR1 targeting siRNA and doxorubicin using a novel cationic poly(lactide-co-glycolide) nanoformulation

International Journal of Pharmaceutics

Volumn 475, Issue 1, 2014, Pages 372-384

  Misra, Ranjita ^a   Das, Manasi ^a   Sahoo, Bhabani Sankar ^a   Sahoo, Sanjeeb K ^a  

^a INSTITUTE OF LIFE SCIENCES   (India)

Author keywords

Cationic nanoparticles; Doxorubicin; MCF 7 ADR cells; Multidrug resistance; P gp; siRNA

Indexed keywords

DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN 1; NANOPARTICLE; POLYGLACTIN; SMALL INTERFERING RNA; WATER OIL CREAM; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CATION; MULTIDRUG RESISTANCE PROTEIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; EMULSION; EVAPORATION; FLOW CYTOMETRY; GENE SILENCING; IN VITRO STUDY; INTERNALIZATION; MCF 7 CELL LINE; MITOCHONDRION; MULTIDRUG RESISTANCE; PARTICLE SIZE; POLYMERIZATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURFACE CHARGE; SURFACE PROPERTY; WESTERN BLOTTING; ZETA POTENTIAL; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HUMAN; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CATIONS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; MCF-7 CELLS; NANOPARTICLES; P-GLYCOPROTEIN; P-GLYCOPROTEINS; POLYGLACTIN 910; RNA, SMALL INTERFERING;

EID: 84907190399     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.056     Document Type: Article

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